SARS‐CoV‐2 antibody dynamics over time and risk factors associated with infection and long COVID‐19 symptoms in large working environments

Hansen, Cecilie Bo; Dvoncova, Kristina; Pérez‐Alós, Laura; Fogh, Kamille; Madsen, Johannes Roth; Garred, Caroline Hartwell; Jarlhelt, Ida; Nielsen, Pernille B; Petersen, Steffan Svejgaard; Fjordager, Charlotte Gandsø; Lauritsen, Klara Tølbøll; Hilsted, Linda; Boding, Lasse; Iversen, Kasper; Hyveled, Liselotte; Garred, Peter

doi:10.1111/joim.13637

Cited by 3 publications

(4 citation statements)

References 35 publications

(60 reference statements)

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“…A large cohort in Monaco also showed that hybrid immunity induces high levels of neutralizing antibody against SARS-CoV-2 [ 27 ]. Another study in Denmark which compared between fully BNT162b2 vaccinated individuals with and without previous SARS-CoV-2 infection also found that the proportion of individuals with high levels of total SARS-CoV-2 antibodies was significantly higher in those with prior infection (72.2%) than in infection-naïve individuals (35.4%), indicating robust humoral response induced by hybrid immunity [ 28 ]. In addition, a study from a large cohort in Sweden also showed hybrid immunity providing a high degree of protection against COVID-19 reinfection and hospitalisation [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Antibody Dynamics after COVID-19 Vaccination and Infection: A Real-World Cross-Sectional Analysis

et al. 2023

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The Coronavirus disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), continues to surge despite the widespread use of vaccination. In Thailand, more than 77% and 39% of the population received two doses and three doses of COVID-19 vaccines as of December 2022, respectively. In addition, during the Omicron predominant period in 2022, more than 70% of Thai individuals have been infected. To gain comprehensive insight into SARS-CoV-2 antibody dynamics following vaccination or following vaccination and infection (hybrid immunity), we performed a cross-sectional analysis of sera samples from individuals who received COVID-19 vaccination and/or have been infected with COVID-19 in Thailand between January 2021 and December 2022. A total of 4126 samples were collected. Humoral immunity was evaluated by quantifying the immunoglobulin (including IgG, IgM, and IgA isotypes) specific to the SARS-CoV-2 receptor-binding domain (RBD) or Ig anti-RBD. The results showed that individuals who received two-dose vaccination alone had lower levels of Ig anti-RBD, which rapidly waned over time. To restore the waning antibody, a third dose vaccination is recommended for uninfected individuals who have only received 2 doses.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Antibody Dynamics after COVID-19 Vaccination and Infection: A Real-World Cross-Sectional Analysis

et al. 2023

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Section: Discussionmentioning

confidence: 99%

“…In Bosnia and Herzegovina, Prguda-Mujic and colleagues reported a reduced risk of positive anti-SARS CoV-2 Ig levels in patients aged over 50 years old [30]. Other studies reported a reduced risk of SARS-CoV-2 positivity in younger individuals [16,45]. This could be due to the fact that elderly individuals are more aware of risks of COVID-19, and thus preventive methods could be more effectively implemented in them [46].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, ageusia was the strongest predictor of IgM seropositivity among the patients. Several studies across COVID-19 burden varying settings also reported the clinical utility of COVID-19 evocating clinical symptoms, or more specifically, fever, anosmia, and ageusia [15,17,18,20,21,45,47]. Ferreira et al recently reported that anosmia/dysgeusia was the most clinically discriminant symptoms in Portuguese municipal workers, with a PPV and specificity of 52.2% and 99.3%, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Serological surveillance reveals a high exposure to SARS-CoV-2 and altered immune response among COVID-19 unvaccinated Cameroonian individuals

Moguem Soubgui,

Ndeme Mboussi,

Kojom Foko

et al. 2024

PLOS Glob Public Health

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Surveillance of COVID-19/SARS-CoV-2 dynamics is crucial to understanding natural history and providing insights into the population’s exposure risk and specific susceptibilities. This study investigated the seroprevalence of SARS-CoV-2 antibodies, its predictors, and immunological status among unvaccinated patients in Cameroon. A multicentre cross-sectional study was conducted between January and September 2022 in the town of Douala. Patients were consecutively recruited, and data of interest were collected using a questionnaire. Blood samples were collected to determine Immunoglobin titres (IgM and IgG), interferon gamma (IFN- γ) and interleukin-6 (IL-6) by ELISA, and CD4+ cells by flow cytometry. A total of 342 patients aged 41.5 ± 13.9 years were included. Most participants (75.8%) were asymptomatic. The overall crude prevalence of IgM and IgG was 49.1% and 88.9%, respectively. After adjustment, the seroprevalence values were 51% for IgM and 93% for IgM. Ageusia and anosmia have displayed the highest positive predictive values (90.9% and 82.4%) and specificity (98.9% and 98.3%). The predictors of IgM seropositivity were being diabetic (aOR = 0.23, p = 0.01), frequently seeking healthcare (aOR = 1.97, p = 0.03), and diagnosed with ageusia (aOR = 20.63, p = 0.005), whereas those of IgG seropositivity included health facility (aOR = 0.15, p = 0.01), age of 40–50 years (aOR = 8.78, p = 0.01), married (aOR = 0.21, p = 0.02), fever (aOR = 0.08, p = 0.01), and ageusia (aOR = 0.08, p = 0.01). CD4+, IFN-γ, and IL-6 were impaired in seropositive individuals, with a confounding role of socio-demographic factors or comorbidities. Although the WHO declared the end of COVID-19 as a public health emergency, the findings of this study indicate the need for continuous surveillance to adequately control the disease in Cameroon.

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Serological surveillance reveals a high exposure to SARS-CoV-2 and altered immune response among COVID-19 unvaccinated Cameroonian individuals

Moguem Soubgui,

Ndeme Mboussi,

Kojom Foko

et al. 2023

Preprint

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Background Surveillance of COVID-19/SARS-CoV-2 dynamics is crucial to understanding natural history and providing insights into the population’s exposure risk and specific susceptibilities. This study investigated the seroprevalence of SARS-CoV-2 antibodies, its predictors, and immunological status among unvaccinated patients in Cameroon. Materials and Methods A multicentre cross-sectional study was conducted between January and September 2022 in the town of Douala. Patients were consecutively recruited, and data of interest were collected using a questionnaire. Blood samples were collected to determine Immunoglobin titres (IgM and IgG) by ALFA, CD4+ cells by flow cytometry, and interferon gamma (IFN- γ) and interleukin-6 (IL-6) by ELISA. Results A total of 342 patients aged 41.5 ± 13.9 years were included. Most participants (75.8%) were asymptomatic. The overall prevalence of IgM and IgG was 49.1% and 88.9%, respectively. Ageusia and anosmia have displayed the highest positive predictive values (90.9% and 82.4%) and specificity (98.9% and 98.3%). The predictors of IgM seropositivity were being aged 60 – 70 years (aOR = 0.54, p = 0.02) and ageusia (aOR = 9.31, p = 0.01), whereas those of IgG seropositivity included health facility (aOR = 0.23, p = 0.02) and ageusia (aOR = 0.21, p = 0.04). CD4+, IFN-γ, and IL-6 were impaired in seropositive individuals, with a confounding role of socio-demographic factors or comorbidities. Conclusion Although the WHO declared the end of COVID-19 as a public health emergency, the findings of this study indicate the need for continuous surveillance to adequately control the disease in Cameroon.

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SARS‐CoV‐2 antibody dynamics over time and risk factors associated with infection and long COVID‐19 symptoms in large working environments

Abstract: Hansen CB, Dvoncova K, Pérez-Alós L, Fogh K, Madsen JR, Garred CH, et al. SARS-CoV-2 antibody dynamics over time and risk factors associated with infection and long COVID-19 symptoms in large working environments.

Cited by 3 publications

References 35 publications

SARS-CoV-2 Antibody Dynamics after COVID-19 Vaccination and Infection: A Real-World Cross-Sectional Analysis

SARS-CoV-2 Antibody Dynamics after COVID-19 Vaccination and Infection: A Real-World Cross-Sectional Analysis

Serological surveillance reveals a high exposure to SARS-CoV-2 and altered immune response among COVID-19 unvaccinated Cameroonian individuals

Serological surveillance reveals a high exposure to SARS-CoV-2 and altered immune response among COVID-19 unvaccinated Cameroonian individuals

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