SARS-CoV-2 and Zoonotic Preparedness: Unknown Knowns?

Irving, Aaron T.; Welburn, Susan C.

doi:10.1097/im9.0000000000000051

Cited by 1 publication

(1 citation statement)

References 19 publications

(22 reference statements)

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“…While initially described as an atypical pneumonia and SARS-like illness, viral genome sequencing quickly identified the causative agent as a SARS-like coronavirus, initially termed nCoV-2019 but subsequently named SARS-CoV-2 (10,27,30). A unique feature that contributed to the rapid global spread of SARS-CoV-2 is the ability for the virus to spread prior to outward signs or symptoms of COVID-19 (31). Within four months of the initial outbreak, SARS-CoV-2 spread across the globe while governments rapidly instituted mitigation measures, including lockdowns and border closures, in an effort to reduce viral spread (32).…”

Section: Sars-cov-2 Covid-19 and The Origins Of Coronavirusesmentioning

confidence: 99%

SARS-CoV-2 and the Missing Link of Intermediate Hosts in Viral Emergence - What We Can Learn From Other Betacoronaviruses

Schindell¹,

Allardice²,

McBride³

et al. 2022

Front. Virol.

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The emergence of SARS-CoV-2 in 2019 has resulted in a global pandemic with devastating human health and economic consequences. The development of multiple vaccines, antivirals and supportive care modalities have aided in our efforts to gain control of the pandemic. However, the emergence of multiple variants of concern and spillover into numerous nonhuman animal species could protract the pandemic. Further, these events also increase the difficulty in simultaneously monitoring viral evolution across multiple species and predicting future spillback potential into the human population. Here, we provide historic context regarding the roles of reservoir and intermediate hosts in coronavirus circulation and discuss current knowledge of these for SARS-CoV-2. Increased understanding of SARS-CoV-2 zoonoses are fundamental for efforts to control the global health and economic impacts of COVID-19.

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