SARS-CoV-2 and the host-immune response

Abstract

The SARS-CoV-2 pandemic and the COVID-19 disease have affected everyone globally, leading to one of recorded history’s most significant research surges. As our knowledge evolves, our approaches to the virus and treatments must also evolve. The evaluation of future research approaches to SARS-CoV-2 will necessitate reviewing the host immune response and viral antagonism of that response. This review provides an overview of the current knowledge on SARS-CoV-2 by summarizing the virus and human response. The focuses are on the viral genome, replication cycle, host immune activation, response, signaling, and antagonism. To effectively fight the pandemic, efforts must focus on the current state of research to help develop treatments and prepare for future outbreaks.

A semi-quantitative visual lateral flow immunoassay for SARS-CoV-2 antibody detection for the follow-up of immune response to vaccination or recovery

“…The Np is a RNA-binding protein necessary for the conservation of the folding of the viral genome. Both proteins can elicit an immune response in the host, 34 and this aspect has been massively exploited. On the one hand, the immune response against Sp, and even more against Np, was used for the indirect diagnosis of infection by serological testing.…”