Sargaquinoic acid and sargachromenol, extracts of Sargassum sagamianum, induce apoptosis in HaCaT cells and mice skin: Its potentiation of UVB-induced apoptosis

Hur, Sun; Lee, Hyangkyu; Kim, Young-Hwa; Lee, Bong Ho; Shin, Jongheon; Kim, Tae Yoon

doi:10.1016/j.ejphar.2007.12.025

Cited by 51 publications

(44 citation statements)

References 26 publications

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“…Although the compounds responsible for this cytoprotective effect were not identified, sargaquinoic acid and sargachromenol isolated by methanol extraction from other species of Sargassum have been shown to influence UV-induced damage to keratinocytes (Hur et al 2008). …”

Section: Cytoprotectionmentioning

confidence: 98%

High-value products from macroalgae: the potential uses of the invasive brown seaweed, Sargassum muticum

Milledge

Nielsen

Bailey³

2015

Rev Environ Sci Biotechnol

145

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Marine seaweeds represent an abundant source of natural products and may harbour valuable chemicals. The brown seaweed Sargassum muticum is an invasive species to the coasts of the British Isles, mainland Europe and North America. Attempts at its eradication and control have generally not been successful, although time-consuming and costly. Commercial exploration of this biomass for food, fuel and pharmaceutical products could encourage its harvesting and control. Though S. muticum might be unsuitable as a source of biofuel due to high ash and water content, this rapidly growing macroalga has a naturally high content of antioxidants, carotenoids and phenols, including the well-known anti-cancer compound fucoxanthin, making this species a potential source of a range of pharmaceutically relevant materials.

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Section: Cytoprotectionmentioning

confidence: 98%

High-value products from macroalgae: the potential uses of the invasive brown seaweed, Sargassum muticum

Milledge

Nielsen

Bailey³

2015

Rev Environ Sci Biotechnol

145

View full text Add to dashboard Cite

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“…Previous studies have affirmed that UVB induces cell death by increasing production of ROS, accounting for elevated cell membrane permeability (Paz et al, 2008), assembly of apoptosomes containing cytochrome c, and cleavage of caspase-9 and caspase-3 (Gulbins et al, 2003). UVB radiation also disrupts the cell's own defense systems by inhibiting the anti-apoptotic protein Bcl-2 (Dash et al, 2008) and up-regulating the pro-apoptotic protein Bax (Hur et al, 2008). We demonstrated here that exposure to UVB initiated apoptotic processes, as shown by the disruption of mitochondrial potential, reduction in Bcl-2 levels, induction of Bax, caspase-9 and caspase-3.…”

Section: Discussionmentioning

confidence: 97%

Photo-protective effect of americanin B against ultraviolet B-induced damage in cultured human keratinocytes

Zheng

Piao

Kim

et al. 2014

Environmental Toxicology and Pharmacology

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“…SQA (Tsang et al, 2001), PC12D nerve growth factor (NGF) SQA (Kamei and Tsang, 2003). SQA SCM apoptosis , (Hur et al, 2008). SHQA .…”

Section: 결과 및 고찰mentioning

confidence: 99%

Effect of Sargassum serratifolium Extracts on β-Amyloid Production

Choi¹,

Jung²,

Kim³

2017

Korean Journal of Fisheries and Aquatic Sciences

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder of insidious onset that causes gradual loss of memory and cognitive function, and it is the most common form of dementia in the elderly. AD is characterized by neuritic plaques and neurofibrillary tangles in the brain, together with loss of neuronal cells. The major neuropathological hallmark of AD is the accumulation of extracellular neurotoxic β-amyloid (Aβ) peptides, such as Aβ1-42, in the brain. In the present study, we investigated the effect of sargachromenol (SCM), sargaquinoic acid (SQA) and sargahydroquinoic acid (SHQA) isolated from Sargassum serratifoilum ethanol extract (SSE) on Aβ production in vitro using APP751-transfected Chinese hamster ovary cells (CHO-751). CHO-751 cells were treated with various concentrations of SSE, SCM, SQA and SHQA, and the level of extracellular Aβ1-42 was evaluated by enzyme-linked immunosorbent assay. SSE and SHQA reduced the production of Aβ1-42 in CHO-751 cells. Therefore, SHQA isolated from S. serratifolium has potential as an inhibitor of neurotoxic Aβ peptide production.

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Sargaquinoic acid and sargachromenol, extracts of Sargassum sagamianum, induce apoptosis in HaCaT cells and mice skin: Its potentiation of UVB-induced apoptosis

Cited by 51 publications

References 26 publications

High-value products from macroalgae: the potential uses of the invasive brown seaweed, Sargassum muticum

High-value products from macroalgae: the potential uses of the invasive brown seaweed, Sargassum muticum

Photo-protective effect of americanin B against ultraviolet B-induced damage in cultured human keratinocytes

Effect of Sargassum serratifolium Extracts on β-Amyloid Production

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