Sargahydroquinoic acid isolated from Sargassum serratifolium as inhibitor of cellular basophils activation and passive cutaneous anaphylaxis in mice

Choi, Kap Seong; Shin, Tai-Sun; Chun, Jiyeon; Ahn, Ginnae; Han, Eui Jeong; Kim, Min-Jong; Kim, Jung-Beom; Kim, Sang-Hyun; Kho, Kang Hee; Kim, Dae Heon; Shim, Sun-Yup

doi:10.1016/j.intimp.2022.108567

Cited by 7 publications

(8 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absolute configuration at C-2 of 6, 7, and 9 was proposed as R based on biogenetic considerations, but the relative configuration of C-2 to the other stereogenic centers had not been determined due to the limited amounts of isolated materials. In addition, six known chromanes were identified as 9′-deoxy-9′-oxosargachromanol K (10) 6 and sargachromanols K (11), G (12), L (13), D ( 14 All compounds were evaluated for their inhibitory activities against LPS-induced inflammation response in murine BV-2 microglial cells. 32,33 Prior to the bioassay, the cytotoxicities of 1−15 against BV-2 cells were determined using the MTT method.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The extensive medicinal value of Sargassum algae is consistent with their structurally diverse secondary metabolites . An intriguing group of these metabolites is the chromane-type meroterpenoids consisting of a polyprenyl chain attached to a hydroquinone ring, represented by sargachromanols isolated from the title species collected in Korea. − Some of the chromanes derived from the genus Sargassum exhibited a variety of pharmaceutical bioactivities, such as anti-inflammatory, antioxidant, and Na + /K + ATPase and acetylcholinesterase (AChE) inhibition properties. ,− Based on their potent anti-inflammatory effects ,− and structural similarity with vitamin E, a molecule with high blood–brain barrier permeability, it would appear a reasonable hypothesis that these chromanes are a promising scaffold for developing therapeutic agents against neuroinflammation-associated brain disorders (Alzheimer’s, Parkinson’s, and Huntington’s disease , ). However, the potential of these chromanes as neuroprotectants against inflammation in the brain is still unknown.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum

Wang

Zhang

et al. 2023

J. Nat. Prod.

View full text Add to dashboard Cite

Nine new chromane-type meroterpenoids, including the rare nor-meroterpenoid sargasilol A (1) and the eight meroditerpenoids sargasilols B–I (2–9), were isolated from a China Sea collection of the brown alga Sargassum siliquastrum, together with six known analogues (10–15). The structures of the new chromanes were identified by extensive spectroscopic analysis and by comparison with previously reported data. Compounds 1–3 and 6–15 exhibited inhibition against LPS-induced NO production in BV-2 microglial cells, and 1, with a shorter carbon chain, was the most active one. Compound 1 was established as an anti-neuroinflammatory agent through targeting the IKK/IκB/NF-κB signaling pathway. As such, the chromanes from brown algae could provide promising anti-neuroinflammatory lead compounds for further structural modification.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum

Wang

Zhang

et al. 2023

J. Nat. Prod.

View full text Add to dashboard Cite

show abstract

“…Sargahydorquinoic acid, isolated from the marine alga Sargassum serratifolium, has been shown to be a potent antioxidant [ 83 , 96 ]. Ginsenoside Re has been isolated from the stem, berry, leaf, flower bud, and root of Panax ginseng and has exhibited a long list of pharmacological effects including neuroprotective effects [ 84 , 85 , 97 , 98 ]. Sulforaphane, found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage, and cauliflower, has anti-apoptotic, antioxidant, and anti-inflammatory properties [ 86 , 99 ].…”

Section: Discussionmentioning

confidence: 99%

A Preclinical Model for Parkinson’s Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies

Segura‐Aguilar

Mannervik

2023

Antioxidants

View full text Add to dashboard Cite

Investigations of the effect of antioxidants on idiopathic Parkinson’s disease have been unsuccessful because the preclinical models used to propose these clinical studies do not accurately represent the neurodegenerative process of the disease. Treatment with certain exogenous neurotoxins induces massive and extremely rapid degeneration; for example, MPTP causes severe Parkinsonism in just three days, while the degenerative process of idiopathic Parkinson´s disease proceeds over many years. The endogenous neurotoxin aminochrome seems to be a good alternative target since it is formed in the nigrostriatal system neurons where the degenerative process occurs. Aminochrome induces all the mechanisms reported to be involved in the degenerative processes of idiopathic Parkinson’s disease. The presence of neuromelanin-containing dopaminergic neurons in the postmortem brain of healthy elderly people suggests that neuromelanin synthesis is a normal and harmless process despite the fact that it requires oxidation of dopamine to three ortho-quinones that are potentially toxic, especially aminochrome. The apparent contradiction that neuromelanin synthesis is harmless, despite its formation via neurotoxic ortho-quinones, can be explained by the protective roles of DT-diaphorase and glutathione transferase GSTM2-2 as well as the neuroprotective role of astrocytes secreting exosomes loaded with GSTM2-2. Increasing the expression of DT-diaphorase and GSTM2-2 may be a therapeutic goal to prevent the degeneration of new neuromelanin-containing dopaminergic neurons. Several phytochemicals that induce DT-diaphorase have been discovered and, therefore, an interesting question is whether these phytochemical KEAP1/NRF2 activators can inhibit or decrease aminochrome-induced neurotoxicity.

show abstract

“…Cytotoxicity of A40 was evaluated using the MTS assay following the method of the previous study [21]. Briefly, KU812F and RBL-2H3 cells were treated with A40 for 1 h, and stimulated with PMACI and com 48/80 for 24 h in serum-free condition, respectively.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

“…The process of preparing whole cell lysates, cytosolic and nuclear proteins conducting western blotting was performed in accordance with previous study [21]. We used primary antibodies against key targets, involving ERK1/2, p-ERK 1/2, p38, p-p38, JNK, p-JNK, NF-B and -actin, and specific HRP-conjugated secondary antibody.…”

Section: Western Blot Analysismentioning

confidence: 99%

Bioactivity-Guided Fraction from Viscera of Abalone, Haliotis discus hannai Suppresses Cellular Basophils Activation and Anaphylaxis in Mice

Choi,

Shin,

Ahn

et al. 2023

J. Microbiol. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Sargahydroquinoic acid isolated from Sargassum serratifolium as inhibitor of cellular basophils activation and passive cutaneous anaphylaxis in mice

Cited by 7 publications

References 41 publications

Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum

Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum

A Preclinical Model for Parkinson’s Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies

Bioactivity-Guided Fraction from Viscera of Abalone, Haliotis discus hannai Suppresses Cellular Basophils Activation and Anaphylaxis in Mice

Contact Info

Product

Resources

About