Sargachromenol Purified from Sargassum horneri Inhibits Inflammatory Responses via Activation of Nrf2/HO-1 Signaling in LPS-Stimulated Macrophages

Han, Eui-Jeong; Jayawardena, Thilina U.; Jang, Jae‐Hyuk; Fernando, Ilekuttige Priyan Shanura; Jee, Youngheun; Jeon, You‐Jin; Lee, Daesung; Lee, Jeong Min; Yim, Mi‐Jin; Wang, Lei; Kim, Hyunsoo; Ahn, Ginnae

doi:10.3390/md19090497

Cited by 14 publications

(9 citation statements)

References 36 publications

(68 reference statements)

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“…Ethanol, methanol, and ethyl acetate S. serratifolium extracts, whose major compounds identified were the meroterpenoids SHQA, SC, and SQA, were reported to dose-dependently (1.25–10 µg/mL) reduce LPS-induced ROS in LPS-stimulated macrophages [ 56 ]. The same trend was observed with SCM and SHQA isolated from S. horneri and S. macrocarpum , respectively [ 48 , 49 ]. In turn, an acetone:ethanol extract of S. glaucescens rich in fucoxanthin caused a decrease in LPS-induced ROS and O 2 •− production in the same cell line at concentrations ranging from 25 µg/mL to 100 µg/mL [ 122 ].…”

Section: Bioactive Potential Of Sargassum Antioxidant Secondary Metab...supporting

confidence: 76%

Applications of Antioxidant Secondary Metabolites of Sargassum spp.

et al. 2023

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Sargassum is one of the largest and most diverse genus of brown seaweeds, comprising of around 400 taxonomically accepted species. Many species of this genus have long been a part of human culture with applications as food, feed, and remedies in folk medicine. Apart from their high nutritional value, these seaweeds are also a well-known reservoir of natural antioxidant compounds of great interest, including polyphenols, carotenoids, meroterpenoids, phytosterols, and several others. Such compounds provide a valuable contribution to innovation that can translate, for instance, into the development of new ingredients for preventing product deterioration, particularly in food products, cosmetics or biostimulants to boost crops production and tolerance to abiotic stress. This manuscript revises the chemical composition of Sargassum seaweeds, highlighting their antioxidant secondary metabolites, their mechanism of action, and multiple applications in fields, including agriculture, food, and health.

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Section: Bioactive Potential Of Sargassum Antioxidant Secondary Metab...supporting

confidence: 76%

Applications of Antioxidant Secondary Metabolites of Sargassum spp.

et al. 2023

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“…These results agree with those found in the literature [ 50 , 51 ], where brown seaweeds also revealed anti-inflammatory potential. Han and co-workers [ 52 ] evaluated the anti-inflammatory effect of sargacromenol isolated from Sargassum horneri in RAW 264.7 macrophages stimulated by LPS. Sargacromenol, besides reducing the production of NO and ROS, also decreased the mRNA expression of inflammatory cytokines, namely IL-1β, IL-6 and TNF-α, and inflammatory mediators, namely iNOS and COX-2.…”

Section: Discussionmentioning

confidence: 99%

Saccorhiza polyschides—A Source of Natural Active Ingredients for Greener Skincare Formulations

et al. 2022

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The growing knowledge about the harmful effects caused by some synthetic ingredients present in skincare products has led to an extensive search for natural bioactives. Thus, this study aimed to investigate the dermatological potential of five fractions (F1–F5), obtained by a sequential extraction procedure, from the brown seaweed Saccorhiza polyschides. The antioxidant (DPPH, FRAP, ORAC and TPC), anti-enzymatic (collagenase, elastase, hyaluronidase and tyrosinase), antimicrobial (Staphylococcus epidermidis, Cutibacterium acnes and Malassezia furfur), anti-inflammatory (nitric oxide, tumor necrosis factor-α, interleukin-6 and interleukin-10) and photoprotective (reactive oxygen species) properties of all fractions were evaluated. The ethyl acetate fraction (F3) displayed the highest antioxidant and photoprotective capacity, reducing ROS levels in UVA/B-exposed 3T3 fibroblasts, and the highest anti-enzymatic capacity against tyrosinase (IC50 value: 89.1 µg/mL). The solid water-insoluble fraction (F5) revealed the greatest antimicrobial activity against C. acnes growth (IC50 value: 12.4 µg/mL). Furthermore, all fractions demonstrated anti-inflammatory potential, reducing TNF-α and IL-6 levels in RAW 264.7 macrophages induced with lipopolysaccharides. Chemical analysis of the S. polyschides fractions by NMR revealed the presence of different classes of compounds, including lipids, polyphenols and sugars. The results highlight the potential of S. polyschides to be incorporated into new nature-based skincare products.

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“…Nuclear magnetic resonance (NMR) spectroscopy was conducted to elucidation of Sargachromenol structure (400 MHz, JNM-ECX400, JEOL, Japan). 1H (CD3OD, 400 MHz) and 13C (CD3OD, 100 MHz) spectra were obtained [36] (Figure 5).…”

Section: Preparation Of 70% Ethanol Extract and Compound Isolationmentioning

confidence: 99%

Sargachromenol Isolated from Sargassum horneri Inhibits Particulate Matter-Induced Inflammation in Macrophages through Toll-like Receptor-Mediated Cell Signaling Pathways

et al. 2021

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Sargassum horneri is an invasive brown seaweed that grows along the shallow coastal areas of the Korean peninsula, which are potentially harmful to fisheries and natural habitats in the areas where it is accumulated. Therefore, the author attempted to evaluate the anti-inflammatory mechanism of Sargachromenol isolated from S. horneri against particulate matter (PM)-stimulated RAW 264.7 macrophages. PM is a potent inducer of respiratory diseases such as lung dysfunctions and cancers. In the present study, the anti-inflammatory properties of Sargachromenol were validated using enzyme-linked immunosorbent assay (ELISA), Western blots, and RT-qPCR experiments. According to the results, Sargachromenol significantly downregulated the PM-induced proinflammatory cytokines, Prostaglandin E2 (PGE2), and Nitric Oxide (NO) secretion via blocking downstream activation of Toll-like receptor (TLR)-mediated nuclear factor kappa B (NF-κB) and MAPKs phosphorylation. Thus, Sargachromenol is a potential candidate for innovation in various fields including pharmaceuticals, cosmeceuticals, and functional food.

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Sargachromenol Purified from Sargassum horneri Inhibits Inflammatory Responses via Activation of Nrf2/HO-1 Signaling in LPS-Stimulated Macrophages

Cited by 14 publications

References 36 publications

Applications of Antioxidant Secondary Metabolites of Sargassum spp.

Applications of Antioxidant Secondary Metabolites of Sargassum spp.

Saccorhiza polyschides—A Source of Natural Active Ingredients for Greener Skincare Formulations

Sargachromenol Isolated from Sargassum horneri Inhibits Particulate Matter-Induced Inflammation in Macrophages through Toll-like Receptor-Mediated Cell Signaling Pathways

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