Sargachromenol Isolated from Sargassum horneri Attenuates Glutamate-Induced Neuronal Cell Death and Oxidative Stress through Inhibition of MAPK/NF-κB and Activation of Nrf2/HO-1 Signaling Pathway

Han, Eui-Jeong; Zhang, Chunying; Kim, Hyunsoo; Kim, Ji-Yul; Park, Sang Myun; Jung, Won‐Kyo; Ahn, Ginnae; Cha, Seon-Heui

doi:10.3390/md20110710

Cited by 3 publications

(1 citation statement)

References 50 publications

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“…Algae have gained attention in biotechnology due to the diverse range of biologically active compounds present in algal biomass, making them suitable for many applications in the field of health and medicine, namely, in the nutraceutical industry [12]. Algal compounds have many activities that were not included in the present review, such as anti-microbial [224], anti-viral [225], anti-bacterial [226], neuroprotective [227], osteogenic potential [228], and immunomodulatory activities [229], which might also benefit human health. Additionally, some bioactive compounds act on plant and animal health (such as biological activities in aquaculture) [230,231] and were not explored in the present review either.…”

Section: Future Directions and Research Gaps 41 Emerging Areas Of Res...mentioning

confidence: 99%

The Ocean’s Pharmacy: Health Discoveries in Marine Algae

Silva,

Avni,

Varela

et al. 2024

Molecules

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Non-communicable diseases (NCDs) represent a global health challenge, constituting a major cause of mortality and disease burden in the 21st century. Addressing the prevention and management of NCDs is crucial for improving global public health, emphasizing the need for comprehensive strategies, early interventions, and innovative therapeutic approaches to mitigate their far-reaching consequences. Marine organisms, mainly algae, produce diverse marine natural products with significant therapeutic potential. Harnessing the largely untapped potential of algae could revolutionize drug development and contribute to combating NCDs, marking a crucial step toward natural and targeted therapeutic approaches. This review examines bioactive extracts, compounds, and commercial products derived from macro- and microalgae, exploring their protective properties against oxidative stress, inflammation, cardiovascular, gastrointestinal, metabolic diseases, and cancer across in vitro, cell-based, in vivo, and clinical studies. Most research focuses on macroalgae, demonstrating antioxidant, anti-inflammatory, cardioprotective, gut health modulation, metabolic health promotion, and anti-cancer effects. Microalgae products also exhibit anti-inflammatory, cardioprotective, and anti-cancer properties. Although studies mainly investigated extracts and fractions, isolated compounds from algae have also been explored. Notably, polysaccharides, phlorotannins, carotenoids, and terpenes emerge as prominent compounds, collectively representing 42.4% of the investigated compounds.

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Section: Future Directions and Research Gaps 41 Emerging Areas Of Res...mentioning

confidence: 99%

The Ocean’s Pharmacy: Health Discoveries in Marine Algae

Silva,

Avni,

Varela

et al. 2024

Molecules

View full text Add to dashboard Cite

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Sargassum horneri Extract Attenuates Depressive-like Behaviors in Mice Treated with Stress Hormone

Park,

Kim,

Kim

et al. 2023

Antioxidants

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Sargassum horneri, a brown seaweed, is known for its various health benefits; however, there are no reports on its effects on depression. This study aimed to investigate the antidepressant effects of S. horneri ethanol extract (SHE) in mice injected with corticosterone (CORT) and to elucidate the underlying molecular mechanisms. Behavioral tests were conducted, and corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and CORT levels were measured. A fluorometric monoamine oxidase (MAO) enzyme inhibition assay was performed. Neurotransmitters like serotonin, dopamine, and norepinephrine levels were determined. Moreover, the ERK-CREB-BDNF signaling pathway in the prefrontal cortex and hippocampus was evaluated. Behavioral tests revealed that SHE has antidepressant effects by reducing immobility time and increasing time spent in open arms. Serum CRH, ACTH, and CORT levels decreased in the mice treated with SHE, as did the glucocorticoid-receptor expression in their brain tissues. SHE inhibited MAO-A and MAO-B activities. In addition, SHE increased levels of neurotransmitters. Furthermore, SHE activated the ERK-CREB-BDNF pathway in the prefrontal cortex and hippocampus. These findings suggest that SHE has antidepressant effects in CORT-injected mice, via the regulation of the hypothalamic-pituitary-adrenal axis and monoaminergic pathway, and through activation of the ERK-CREB-BDNF signaling pathway. Thus, our study suggests that SHE may act as a natural antidepressant.

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Sargassum horneri Extract Ameliorates DSS-Induced Colitis through Modulation of mTOR Axis and Intestinal Microbiota

Wang

Park

et al. 2023

Applied Sciences

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Ulcerative colitis is a chronic inflammatory bowel disease characterized by colonic mucosal inflammation, intestinal microflora imbalance, and intestinal permeability. It is essential to develop natural compounds with anti-inflammatory and intestinal bacterial imbalance correction properties. The brown alga Sargassum horneri is rich in polyphenols, such as fucoxanthin and chromene, which have antioxidant, anti-inflammatory, and anti-cancer properties. In results, S. horneri ethanol extract (SHE) reduced TNF-α and IL-6 levels as well as Pi3k/Mtor/S6k mRNA expression in LPS-treated RAW264.7 and Caco-2 cells. In addition, SHE treatment decreased the expression of genes associated with inflammation and the mTOR axis in the co-culture system while increasing the expression of tight junction factors. In a mouse model of dextran sulfate sodium (DSS)-induced colitis, SHE treatment improved intestinal length, histological scores, and the expression of genes related to tight junctions while decreasing the expression of genes related to inflammatory markers and the mTOR axis. The gut microbiota of mice treated with SHE exhibited a decrease in the ratio of Firmicutes to Bacteroidota, which had been increased by DSS treatment and an increase in beneficial bacteria. Therefore, SHE consumption may be a useful natural alternative, as it improves gut microbiota, alleviates colitis symptoms, and prevents their onset.

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Sargachromenol Isolated from Sargassum horneri Attenuates Glutamate-Induced Neuronal Cell Death and Oxidative Stress through Inhibition of MAPK/NF-κB and Activation of Nrf2/HO-1 Signaling Pathway

Cited by 3 publications

References 50 publications

The Ocean’s Pharmacy: Health Discoveries in Marine Algae

The Ocean’s Pharmacy: Health Discoveries in Marine Algae

Sargassum horneri Extract Attenuates Depressive-like Behaviors in Mice Treated with Stress Hormone

Sargassum horneri Extract Ameliorates DSS-Induced Colitis through Modulation of mTOR Axis and Intestinal Microbiota

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