Sarcopenia is associated with incident albuminuria in patients with type 2 diabetes: A retrospective observational study

Bouchi, Ryotaro; Fukuda, Tatsuya; Takeuchi, Takato; Minami, Isao; Yoshimoto, Takanobu; Ogawa, Yoshihiro

doi:10.1111/jdi.12636

Cited by 37 publications

(48 citation statements)

References 24 publications

(26 reference statements)

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“…In a previous study, the prevalence of sarcopenia in older patients with diabetes was 19% in men and 27% in women, which is similar to that observed in the present study . In another study that targeted diabetes patients, the prevalence of sarcopenia was 17.6% . Presumably, differences in participant age, comorbidities and sarcopenia definition strongly influenced the outcomes.…”

Section: Discussionsupporting

confidence: 87%

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Association between sarcopenia and sleep disorder in older patients with diabetes

Ida

Kaneko

Nagata

et al. 2019

Geriatrics Gerontology Int

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Aim In the present study, we aimed to examine the association between sarcopenia and sleep disorder in older patients with diabetes using the Japanese version of SARC‐F (SARC‐F‐J). Methods Outpatients with diabetes (aged ≥65 years) at the Ise Red Cross Hospital were included in the present study. We used the Japanese version of the Pittsburgh Sleep Quality Index, which is a self‐administered questionnaire, to measure sleep disorder. To evaluate sarcopenia, we used SARC‐F‐J, a self‐administered questionnaire, comprising five items. For multiple logistic regression analysis, the dependent variable was sleep disorder and the explanatory variable was sarcopenia, and these were used for calculating the odds ratios of sarcopenia with regard to sleep disorder. Results In total, 318 patients were included in this study (189 men and 129 women). The prevalence of sarcopenia was 22.5% and that of sleep disorder was 44.8%. Adjusted odds ratios of sarcopenia and sleep disorder were 6.04 in men (95% CI 1.71–21.36, P = 0.005) and 6.33 in women (95% CI 1.91–20.97, P = 0.003). Conclusions We found a statistically significant association between sarcopenia and sleep disorder in older patients with diabetes using SARC‐F‐J. Therefore, older patients with diabetes should be cautioned regarding sleep disorder if they are diagnosed with sarcopenia. Geriatr Gerontol Int 2019; 19: 399–403.

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Section: Discussionsupporting

confidence: 87%

“…7 In another study that targeted diabetes patients, the prevalence of sarcopenia was 17.6%. 24 Presumably, differences in participant age, comorbidities and sarcopenia definition strongly influenced the outcomes. Compared with patients without diabetes, those with diabetes had a higher prevalence of sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

Association between sarcopenia and sleep disorder in older patients with diabetes

Ida

Kaneko

Nagata

et al. 2019

Geriatrics Gerontology Int

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“…To date, however, no study has investigated the potential association of sarcopenia with the rate of decline in eGFR. In addition to our previous finding of a significant association between sarcopenia and incident albuminuria , in the present study, we showed that sarcopenia was independently associated with the annual rate of decline in eGFR after adjustment for confounding variables in people with type 2 diabetes. Although low eGFR is a confounding factor in the relationships between sarcopenia and rate of decline in eGFR , the association remained unchanged even in the sensitivity analysis of people with eGFR ≥60 ml/min/1.73m 2 .…”

Section: Discussionsupporting

confidence: 77%

Sarcopenic obesity is associated with a faster decline in renal function in people with type 2 diabetes

Fukuda

Bouchi²,

Asakawa

et al. 2019

Diabet. Med.

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Aim To evaluate the association between sarcopenic obesity and the decline in estimated GFR in people with type 2 diabetes. Methods We enrolled 745 people with type 2 diabetes (mean age 64.6 years, 53.6% men). Body composition was evaluated using dual‐energy X‑ray absorptiometry. Skeletal muscle index, calculated as appendicular non‐fat mass (kg) divided by height squared (m2), was used to determine sarcopenia. Sarcopenic obesity was defined as the coexistence of sarcopenia and a ratio of android to gynoid fat mass greater than the median values in each gender. The association of sarcopenic obesity both with the annual rate of decline in estimated GFR and a >30% decline in estimated GFR was evaluated using multivariate linear regression models and Cox proportional hazard models, respectively. Results Participants with sarcopenic obesity were at an increased risk of a high annual rate of decline in estimated GFR, even after adjustment for the confounding variables (standardized β = −0.228, P <0.001). Sarcopenic obesity was also significantly associated with risk of a >30% decline in estimated GFR (hazard ratio 4.52, 95% CI 2.16–9.47; P < 0.01) in multivariate model. Conclusions Sarcopenic obesity evaluated by dual energy X‑ray absorptiometry is associated with a faster decline in renal function in people with type 2 diabetes.

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“…This is in line with the association of albuminuria with sarcopenia, a condition characterized by decreases in muscle mass, strength, and function, which was reported in previous studies including individuals without diabetes. [35][36][37] Albuminuria reflects endothelial dysfunction and generalized vascular damage, [38][39][40] which may affect muscle metabolism leading to reduced muscle strength. Impaired microcirculation, microinflammation, and oxidative stress within the muscle capillaries may be involved in this association.…”

Section: Discussionmentioning

confidence: 99%

Applications of physical performance measures to routine diabetes care for frailty prevention concept: fundamental data with grip strength, gait speed, timed chair stand speed, standing balance, and knee extension strength

Yokoyama¹,

Shiraiwa²,

Takahara

et al. 2020

BMJ Open Diab Res Care

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IntroductionProgression of muscle strength weakening will lead to a poor physical performance and disability. While this is particularly important in patients with diabetes, the associations of reduced muscle strength measured by grip strength with clinical features and physical performance remain unclear. We investigated clinical features and physical performance measures in association with grip strength in elderly people with diabetes in a primary care setting.Research design and methodsA cross-sectional study was conducted enrolling 634 male and 323 female Japanese patients with type 2 diabetes aged 60 years or older. First, grip strength was measured and the associations of gender-specific grip strength with clinical features were evaluated. Second, in patients with a grip strength below the gender-specific median, physical performance measures, including gait speed, timed chair stand speed, knee extension strength, standing balance, and short physical performance battery scores, were investigated. Patients with and without a low performance defined by Asian Working Group for Sarcopenia were compared in terms of clinical features and physical performance measures.ResultsGrip strength decreased according to aging and longer duration of diabetes and was independently related to body mass index, glycated hemoglobin A1c (HbA1c), serum albumin, albuminuria, neuropathy, and stroke in male patients, and to body mass index and albuminuria in female patients. The physical performance measures became worse proportionally to a decrease in the grip strength. Patients with a low performance exhibited a significantly older age, lower grip strength and serum albumin, higher albuminuria, and poorer physical performance measures than those without.ConclusionsReduced grip strength was associated with glycemic exposure indicators of age-related duration, HbA1c, and vascular complications. The physical performance measures became worse with decreasing grip strength. Measurements of grip strength and physical performance in patients with diabetes may help promote intervention to prevent frailty in future studies.

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Sarcopenia is associated with incident albuminuria in patients with type 2 diabetes: A retrospective observational study

Cited by 37 publications

References 24 publications

Association between sarcopenia and sleep disorder in older patients with diabetes

Association between sarcopenia and sleep disorder in older patients with diabetes

Sarcopenic obesity is associated with a faster decline in renal function in people with type 2 diabetes

Applications of physical performance measures to routine diabetes care for frailty prevention concept: fundamental data with grip strength, gait speed, timed chair stand speed, standing balance, and knee extension strength

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