Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis

Bai, Tingting; Fang, Fang; Li, Fei-Ka; Ren, Yan; Hu, Junjie; Cao, Jianjun

doi:10.1186/s12877-020-01672-y

Cited by 77 publications

(61 citation statements)

References 35 publications

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“…This is important since a recent meta-analysis showed that sarcopenia could be observed in 31.4% of patients with CAD [ 54 ]. Sarcopenia has also been associated with hypertension in older adults [ 55 ], with type 2 diabetes [ 26 , 56 , 57 ], and obesity [ 58 , 59 ]. Hypertension, diabetes, and obesity are also risk factors for the occurrence of CAD [ 27 , 60 – 62 ] but are also well-known factors for adverse outcomes in patients with CAD [ 62 – 65 ].…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis

Xue

Ren

et al. 2021

BMC Geriatr

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Background The development of sarcopenia is attributed to normal aging and factors like type 2 diabetes, obesity, inactivity, reduced testosterone levels, and malnutrition, which are factors of poor prognosis in patients with coronary artery disease (CAD). This study aimed to perform a meta-analysis to assess whether preoperative sarcopenia can be used to predict the outcomes after cardiac surgery in elderly patients with CAD. Methods PubMed, Embase, the Cochrane library, and Web of Science were searched for available papers published up to December 2020. The primary outcome was major adverse cardiovascular outcomes (MACE). The secondary outcomes were mortality and heart failure (HF)-related hospitalization. The random-effects model was used. Hazard ratios (HRs) with 95% confidence intervals (95%CIs) were estimated. Results Ten studies were included, with 3707 patients followed for 6 months to 4.5 ± 2.3 years. The sarcopenia population had a higher rate of MACE compared to the non-sarcopenia population (HR = 2.27, 95%CI: 1.58–3.27, P < 0.001; I2 = 60.0%, Pheterogeneity = 0.02). The association between sarcopenia and MACE was significant when using the psoas muscle area index (PMI) to define sarcopenia (HR = 2.86, 95%CI: 1.84–4.46, P < 0.001; I2 = 0%, Pheterogeneity = 0.604). Sarcopenia was not associated with higher late mortality (HR = 2.15, 95%CI: 0.89–5.22, P = 0.090; I2 = 91.0%, Pheterogeneity < 0.001), all-cause mortality (HR = 1.35, 95%CI: 0.14–12.84, P = 0.792; I2 = 90.5%, Pheterogeneity = 0.001), and death, HF-related hospitalization (HR = 1.37, 95%CI: 0.59–3.16, P = 0.459; I2 = 62.0%, Pheterogeneity = 0.105). The sensitivity analysis revealed no outlying study in the analysis of the association between sarcopenia and MACE after coronary intervention. Conclusion Sarcopenia is associated with poor MACE outcomes in patients with CAD. The results could help determine subpopulations of patients needing special monitoring after CAD surgery. The present study included several kinds of participants; although non-heterogeneity was found, interpretation should be cautious.

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Section: Discussionmentioning

confidence: 99%

Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis

Xue

Ren

et al. 2021

BMC Geriatr

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“…Lower HGS was associated with incident T2DM [15,39,40], and meta-analysis results using the results of 10 observational cohort studies also demonstrated its relevance to DM [8]. Weak HGS is associated with HTN [9,41]. The results of HGS and MetS showed contradictory results.…”

Section: Discussionmentioning

confidence: 99%

Relative Hand Grip and Back Muscle Strength, but Not Mean Muscle Strength, as Risk Factors for Incident Metabolic Syndrome and Its Metabolic Components: 16 Years of Follow-Up in a Population-Based Cohort Study

Jeon

Lee²,

Shin³

2021

Applied Sciences

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Muscle strength is associated with health outcomes and can be considered an important disease predictor. There are several studies examining the relationship between hand grip strength (HGS) and metabolic syndrome (MetS). However, no results have been reported for long term longitudinal studies. In this study, we investigated the relationship between mean HGS, back muscle strength (BMS), relative HGS and BMS, and MetS. A total of 2538 non-MetS subjects aged 40–69 years (1215 women and 1323 men) in the Korean Genome and Epidemiology Study (KoGES) Ansan cohort were followed for 16 years. The relationships between incident MetS (iMetS) and muscle strength were estimated using Cox proportional hazard regression models after adjusting for the confounding factors. Increases in standard deviation (SD) and the lower quartile groups for relative HGS and BMS were significantly associated with iMetS in men and women. Moreover, increases in SD and high quintile groups (decreased HGS group) for the delta change in the mean and relative HGS were significantly associated with iMetS in men only. In addition, SD increases for the relative HGS and BMS were significantly associated with iMetS components in men and women. The present study suggests that lower relative HGS and BMS are associated with high risk for the future development of MetS.

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“…Because sarcopenia is more common in people with hypertension, the risk of stroke is higher in people with high blood pressure and muscle weakness (Bai et al, 2020). In this regard, the screening of sarcopenia in obese and elderly people is essential.…”

Section: Open Access | Research Notes Issn: 2576-828xmentioning

confidence: 99%

“…The interview included questions related to participants' demographic and lifestyle characteristics based on the Food Frequency Questionnaire and the Global Physical Activity Questionnaire (Armstrong & Bull, 2006;World Health Organization, 2008). Education and family income variables were categorized as low, medium, or high levels, separately.…”

Section: Covariates and Other Variablesmentioning

confidence: 99%

Association between hand-grip strength and risk of stroke among Mongolian adults: Results from a population-based study

Altankhuyag¹,

Byambaa²,

Tuvshinjargal³

et al. 2021

Neurosci Res Notes

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Mongolia ranks third in the world in stroke-related deaths. Loss of skeletal muscle mass and function, known as sarcopenia, is associated with a higher risk of various metabolic disorders such as stroke. Thus, screening of sarcopenia is important. Hand-grip strength (HGS) can be used to predict sarcopenia in the short term. In this cross-sectional study, we used data (n=1180, mean age of 39.2 ± 15.2 and 33.2% males) from the Mon-Timeline cohort study, a multidisciplinary, prospective, population-based cohort study in Mongolia. A digital grip strength dynamometer (TKK 5401 GRIP D; Takei, Japan) was used to measure HGS. We performed binary logistic regression analysis between HGS and stroke risk. Suspected sarcopenia was defined when HGS is less than the 25th percentile of HGS. In this study, 3.3% of all participants had a stroke. The incidence of stroke was significantly higher (5.2% and 1.9%) in people with suspected sarcopenia. According to body composition, the incidence of stroke was more frequent in sarcopenic obese people: 1.3%, 2.4%, 2.8% and 6.2% in normal (non-obese and non-sarcopenic), sarcopenic (non-obese), obese (non-sarcopenic) and sarcopenic obese groups, respectively. In regression analysis, the OR (95% CI) was 2.84 (1.44; 5.59) for sarcopenic compared with non-sarcopenic. The adjustments for age, gender, education, body mass index, waist circumference and hypertensive status attenuated the associations, but lower HGS remained significantly associated with a higher risk of stroke. In conclusion, lower HGS was significantly associated with a higher risk of stroke independent of adiposity and hypertensive status in Mongolian adults.

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Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis

Cited by 77 publications

References 35 publications

Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis

Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis

Relative Hand Grip and Back Muscle Strength, but Not Mean Muscle Strength, as Risk Factors for Incident Metabolic Syndrome and Its Metabolic Components: 16 Years of Follow-Up in a Population-Based Cohort Study

Association between hand-grip strength and risk of stroke among Mongolian adults: Results from a population-based study

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