Sarcopenia is Associated Cognitive Impairment Mainly Due to Slow Gait Speed: Results from the Korean Frailty and Aging Cohort Study (KFACS)

Kim, Miji; Won, Chang Won

doi:10.20944/preprints201904.0240.v1

Cited by 24 publications

(12 citation statements)

References 52 publications

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“…Our ndings agree with the recommended AWGS19 cut-off for GS criteria, despite a different walk distance of 6m in AWGS19 and 8ft in the present study (11). Other studies also reported a GS of <1.0 m/s in sarcopenic older adults (34), and found greater dementia risk and poorer health outcomes in adults >80 years with GS of <1.0 m/s (35,36). However, GS cut-off recommendations varied according to sarcopenia-associated health outcomes, such as hospitalisation, falls, mortality, cognitive impairment (37).…”

Section: Discussionsupporting

confidence: 90%

SPPB reference values and performance in assessing sarcopenia in community-dwelling Singaporeans – Yishun Study

Lee

Choo

Pang

et al. 2021

Preprint

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Background: The Short Physical Performance Battery (SPPB) is an established test of physical performance. We provide reference values for SPPB and determine SPPB performance and cut-offs in assessing sarcopenia for Asian community-dwelling older adults.Methods: 538 (57.8% women) community-dwelling adults aged 21–90 years were recruited. SPPB and its subtest scores and timings (8ft gait speed (GS), five-times repeated chair sit-to-stand (STS) and balance) were determined. Appendicular lean mass divided by height-squared, muscle strength (handgrip) and physical performance (6m GS, STS and SPPB) were assessed to define sarcopenia for various Asian criteria. Area under the ROC curve (AUC) was used to assess performance of SPPB and subtests in discriminating sarcopenia in adults aged ≥60 years. Optimal SPPB and GS subtest cut-offs for each sarcopenia criterion were determined by maximizing sensitivity and specificity. Results: The mean SPPB score was 11.6(SD 1.1) in men and 11.5(SD1.2) in women. Majority of participants(≥50%) aged 21–80 years achieved the maximum SPPB score. SPPB total and subtest scores generally decreased with age (all p<0.001), but did not differ between sex. Among older adults (≥60 years), SPPB and GS subtest had varied performance in assessing sarcopenia (AUC 0.54–0.64 and 0.51–0.72, respectively), and moderate-to-excellent performance in assessing severe sarcopenia (AUC 0.69–0.98 and 0.75–0.95, respectively), depending on sarcopenia definitions. The optimal cut-offs for discriminating sarcopenia in both sexes were SPPB ≤11points and GS subtest ≤1.0m/s. The most common optimal cut-offs for discriminating severe sarcopenia according to various definitions were SPPB ≤11points in both sexes, and GS ≤0.9m/s in men and ≤1.0m/s in women.Conclusions: Population-specific normative SPPB values are important for use in diagnostic criteria and to interpret results of studies evaluating and establishing appropriate treatment goals. Performance on the SPPB should be reported in terms of the total sum score and registered time to complete the repeated-chair STS and 8-ft walk tests. The performance of GS subtest was comparable to SPPB and could be a useful, simple and accessible screening tool for discriminating severe sarcopenia in community-dwelling older adults.

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Section: Discussionsupporting

confidence: 90%

SPPB reference values and performance in assessing sarcopenia in community-dwelling Singaporeans – Yishun Study

Lee

Choo

Pang

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

SPPB reference values and performance in assessing sarcopenia in community-dwelling Singaporeans – Yishun Study

Lee

Choo

Pang

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The Short Physical Performance Battery (SPPB) is an established test of physical performance. We provide reference values for SPPB and determine SPPB performance and cut-offs in assessing sarcopenia for Asian community-dwelling older adults.Methods: 538 (57.8% women) community-dwelling adults aged 21–90 years were recruited. SPPB and its subtest scores and timings (8ft gait speed (GS), five-times repeated chair sit-to-stand (STS) and balance) were determined. Appendicular lean mass divided by height-squared, muscle strength (handgrip) and physical performance (6m GS, STS and SPPB) were assessed to define sarcopenia for various Asian criteria. Area under the ROC curve (AUC) was used to assess performance of SPPB and subtests in discriminating sarcopenia. Optimal SPPB and GS subtest cut-offs for each sarcopenia criterion were determined by maximizing sensitivity and specificity.Results: The mean SPPB score was 11.6(SD 1.1) in men and 11.5(SD1.2) in women. Majority of participants(≥50%) aged 21–80 years achieved the maximum SPPB score. SPPB total and subtest scores generally decreased with age (all p<0.001), but did not differ between sex. SPPB was limited in assessing sarcopenia (AUC 0.56–0.64) but had moderate-to-excellent performance in assessing severe sarcopenia (AUC 0.69–0.98), with optimal cut-off of ≤11points. SPPB GS subtest had moderate-to-excellent performance in assessing sarcopenia (AUC 0.62–0.72) and severe sarcopenia (AUC 0.81–0.95). The optimal GS cut-off for sarcopenia was 1.0m/s.Conclusions: Population-specific normative SPPB values are important for use in diagnostic criteria and to interpret results of studies evaluating and establishing appropriate treatment goals. Performance on the SPPB should be reported in terms of the total sum score and registered time to complete the repeated-chair STS and 8-ft walk tests. An SPPB cut-off of ≤11points was optimal in assessing sarcopenia. GS subtest could be an independent criterion for discriminating sarcopenia in community-dwelling older adults.

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“…Previous cross-sectional and longitudinal studies have been conducted to determine the relationship between sarcopenia and cognitive status, which have yielded inconsistent conclusions. [ 4 ] Our findings revealed no association between sarcopenia as previously defined and cognitive impairment, after adjusting for potential covariates. The results of the present study were consistent with available evidence from a French observational, prospective, multicenter cohort study of community-dwelling elderly women.…”

contrasting

confidence: 53%

Association between sarcopenia and cognitive impairment in community-dwelling population

Zhu

Feng

et al. 2020

Chinese Medical Journal

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Sarcopenia is Associated Cognitive Impairment Mainly Due to Slow Gait Speed: Results from the Korean Frailty and Aging Cohort Study (KFACS)

Cited by 24 publications

References 52 publications

SPPB reference values and performance in assessing sarcopenia in community-dwelling Singaporeans – Yishun Study

SPPB reference values and performance in assessing sarcopenia in community-dwelling Singaporeans – Yishun Study

SPPB reference values and performance in assessing sarcopenia in community-dwelling Singaporeans – Yishun Study

Association between sarcopenia and cognitive impairment in community-dwelling population

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