Sarcopenia, Exercise and Quality of Life

Mielgo-Ayuso, Juan; Fernández-Lázaro, Diego

doi:10.3390/ijerph18105156

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…Although its mechanisms have not yet been identified, sarcopenia is defined as a decrease in muscle mass and muscle strength due to changes in numerous body components triggered by aging, lack of exercise, and hormonal imbalance [ 8 , 9 , 10 , 11 ]. More than 50 million people worldwide developed sarcopenia in 2000; this number is expected to increase to more than 200 million by 2040 [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Sarcopenia with Osteopenia and Osteoporosis in Community-Dwelling Older Korean Adults: A Cross-Sectional Study

Lee

Shin

2021

JCM

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Sarcopenia and bone disorders, such as osteopenia and osteoporosis, are common musculoskeletal disorders in older adults. Therefore, this study aimed to establish the association between sarcopenia and bone disorders such as osteoporosis and osteopenia according to sex. We analyzed 3077 participants from the 2008–2011 Korean National Health and Nutrition Examination Survey aged 65 years or older. After adjusting for all covariates, such as physical examinations, exercise, and nutrient intake (model 4), the odds ratios for the association between sarcopenia and bone disorders were 2.051 (95% confidence interval [CI]: 1.498–2.808) in osteopenia and 2.258 (95% CI: 1.584–3.218) in osteoporosis. However, when sex was analyzed separately, the odds ratio was significantly different in men (osteopenia—2.068, 95% CI: 1.462–2.924; osteoporosis—3.247, 95% CI: 1.953–5.399), but not in women. Therefore, the results of this study show an association between sarcopenia and bone disorders in older Korean adults. Sarcopenia is significantly related to osteopenia and osteoporosis, especially in men, when stratified by sex.

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Section: Introductionmentioning

confidence: 99%

Association of Sarcopenia with Osteopenia and Osteoporosis in Community-Dwelling Older Korean Adults: A Cross-Sectional Study

Lee

Shin

2021

JCM

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Urban-rural differences in the prevalence and associated factors of sarcopenia: A systematic review and meta-analysis

Li,

Wang,

Hou

et al. 2024

Archives of Gerontology and Geriatrics

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Role of muscle FOXO gene in exercise against the skeletal muscle and cardiac age-related defects and mortality caused by high-salt intake in Drosophila

et al. 2023

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FOXO has long been associated with aging, exercise, and tissue homeostasis, but it remains unclear what the role is of the muscle FOXO gene in E against high-salt intake(HSI)-induced age-related defects of the skeletal muscle, heart, and mortality. In this research, overexpression and RNAi of the FOXO gene in the skeletal and heart muscle of Drosophila were constructed by building Mhc-GAL4/FOXO-UAS-overexpression and Mhc-GAL4/FOXO-UAS-RNAi system. The skeletal muscle and heart function, the balance of oxidation and antioxidant, and mitochondrial homeostasis were measured. The results showed that exercise reversed the age-related decline in climbing ability and downregulation of muscle FOXO expression induced by HSI. Muscle-specific FOXO-RNAi (FOXO-RNAi) and -overexpression (FOXO-OE) promoted or slowed the age-related decline in climbing ability, heart function, and skeletal muscle and heart structure damage, which was accompanied by the inhibition or activation of FOXO/PGC-1α/SDH and FOXO/SOD pathway activity, and oxidative stress (ROS) increased or decreased in both skeletal muscle and heart. The protective effect of exercise on the skeletal muscle and heart was blocked by FOXO-RNAi in aged HSI flies. FOXO-OE prolonged its lifespan, but it did not resist the HSI-induced lifespan shortening. Exercise did not improve HSI-induced lifespan shortening in FOXO-RNAi flies. Therefore, current results confirmed that the muscle FOXO gene played a vital role in exercise against age-related defects of the skeletal muscle and heart induced by HSI because it determined the activity of muscle FOXO/SOD and FOXO/PGC-1α/SDH pathways. The muscle FOXO gene also played an important role in exercise against HSI-induced mortality in aging flies.

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Sarcopenia, Exercise and Quality of Life

Abstract: The loss of strength, power, and muscle mass caused by the progressive deterioration from aging is known as “sarcopenia [...]

Cited by 5 publications

References 12 publications

Association of Sarcopenia with Osteopenia and Osteoporosis in Community-Dwelling Older Korean Adults: A Cross-Sectional Study

Association of Sarcopenia with Osteopenia and Osteoporosis in Community-Dwelling Older Korean Adults: A Cross-Sectional Study

Urban-rural differences in the prevalence and associated factors of sarcopenia: A systematic review and meta-analysis

Role of muscle FOXO gene in exercise against the skeletal muscle and cardiac age-related defects and mortality caused by high-salt intake in Drosophila

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