Sarcopenia Diagnosed Using Masseter Muscle Diameter as a Survival Correlate in Elderly Patients with Glioblastoma

Morshed, Ramin A.; Young, Jacob S; Casey, Megan; Wang, Elaina J; Aghi, Manish K.; Berger, Mitchel S.; Hervey-Jumper, Shawn L.

doi:10.1016/j.wneu.2022.02.038

Cited by 10 publications

(16 citation statements)

References 36 publications

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“…Most of the studies were conducted in Austria (6 studies). 4 , 8 , 24 , 25 , 26 , 27 There were two studies from Turkey, 28 , 29 two from USA, 30 , 31 two from Germany, 32 , 33 two from Italy, 34 , 35 one from South Korea, 36 one from the Netherlands 37 and one from China. 38 Our review includes 17 retrospective cohort studies.…”

Section: Resultsmentioning

confidence: 99%

“… 38 Our review includes 17 retrospective cohort studies. 4 , 8 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 There were three intracranial conditions, and the association between TMT and four outcome measures investigated across the 17 studies.…”

Section: Resultsmentioning

confidence: 99%

“…In glioblastoma patients, ten studies investigated overall survival (OS) 26 , 27 , 28 , 30 , 31 , 33 , 34 , 36 , 37 , 38 ; four studies investigated progression free survival (PFS) 26 , 27 , 36 , 37 ; one study investigated early discontinuation of treatment due to toxicity and/or disease progression 37 ; and two studies investigated treatment-related complications. 31 , 37 For patients with brain metastases, five studies investigated OS 8 , 24 , 25 , 29 , 32 and one study investigated PFS. 24 Two studies investigated OS in PCNSL patients 4 , 35 while only one study investigated PFS in the same condition.…”

Section: Resultsmentioning

confidence: 99%

“…10 studies (13 sub-cohorts) involving 2885 patients, investigated the association between baseline TMT and OS in glioblastoma patients. 26 , 27 , 28 , 30 , 31 , 33 , 34 , 36 , 37 , 38 Three of the studies each had two sub-cohorts. 26 , 27 , 30 One study assessed TMT as a continuous variable, 33 while nine studies dichotomised TMT values as ‘thick’ vs ‘sarcopenic’.…”

Section: Association Between Tmt and Patient Outcomesmentioning

confidence: 99%

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The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis

Olukoya,

Osunronbi,

Jesuyajolu

et al. 2024

World Neurosurgery: X

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Association Between Tmt and Patient Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis

Olukoya,

Osunronbi,

Jesuyajolu

et al. 2024

World Neurosurgery: X

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“…The masseter muscle can be easily visualized and measured during routine imaging evaluations of HNC patients without necessitating an additional imaging protocol. Previous studies have consistently identified masseter muscle-defined sarcopenia as an unfavorable prognosticator for various cancers, including glioblastoma multiforme, esophageal cancer, and HNCs [11][12][13][14]. A correlation between the chosen muscle area or index and survival outcomes has been established in such studies [4,[7][8][9][10][11]14].…”

Section: Introductionmentioning

confidence: 93%

Pretreatment Masseter Muscle Volume Predicts Survival in Locally Advanced Nasopharyngeal Carcinoma Patients Treated with Concurrent Chemoradiotherapy

Pehlivan,

Somay,

Yilmaz

et al. 2023

JCM

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Background and purpose: Muscle loss is a significant indicator of cancer cachexia and is associated with a poor prognosis in cancer patients. Given the absence of comparable studies, the current retrospective study sought to examine the correlation between the total masseter muscle volume (TMMV) before treatment and the survival outcomes in locally advanced nasopharyngeal cancer (LA-NPC) patients who received definitive concurrent chemoradiotherapy (CCRT). Methods: A three-dimensional segmentation model was used to determine the TMMV for each patient by analyzing pre-CCRT magnetic resonance imaging. The optimal TMMV cutoff values were searched using receiver operating characteristic (ROC) curve analyses. The primary and secondary endpoints were the relationship between the pre-CCRT TMMV measures and overall survival (OS) and progression-free survival (PFS), respectively. Results: Ninety-seven patients were included in this study. ROC curve analyses revealed 38.0 cc as the optimal TMMV cutoff: ≤38.00 cc (n = 42) and >38.0 cc (n = 55). Comparisons between the two groups showed that the TMMV>38.0 cc group had significantly longer PFS [Not reached (NR) vs. 28; p < 0.01] and OS (NR vs. 71; p < 0.01) times, respectively. The results of the multivariate analysis demonstrated that the T-stage, N-stage, number of concurrent chemotherapy cycles, and TMMV were independent associates of PFS (p < 0.05 for each) and OS (p < 0.05 for each) outcomes, respectively. Conclusion: The findings of the current retrospective research suggest that pretreatment TMMV is a promising indicator for predicting survival outcomes in LA-NPC patients receiving definitive CCRT.

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Reduced temporal muscle thickness predicts shorter survival in patients undergoing chronic subdural haematoma drainage

Korhonen,

Arponen,

Steinruecke

et al. 2024

J cachexia sarcopenia muscle

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BackgroundChronic subdural haematoma (CSDH) drainage is a common neurosurgical procedure. CSDHs cause excess mortality, which is exacerbated by frailty. Sarcopenia contributes to frailty – its key component, low muscle mass, can be assessed using cross‐sectional imaging. We aimed to examine the prognostic role of temporal muscle thickness (TMT) measured from preoperative computed tomography head scans among patients undergoing surgical CSDH drainage.MethodsWe retrospectively identified all patients who underwent CSDH drainage within 1 year of February 2019. We measured their mean TMT from preoperative computed tomography scans, tested the reliability of these measurements, and evaluated their prognostic value for postoperative survival.ResultsOne hundred and eighty‐eight (122, 65% males) patients (median age 78 years, IQR 70–85 years) were included. Thirty‐four (18%) patients died within 2 years, and 51 (27%) died at a median follow‐up of 39 months (IQR 34–42 months). Intra‐ and inter‐observer reliability of TMT measurements was good‐to‐excellent (ICC 0.85–0.97, P < 0.05). TMT decreased with age (Pearson's r = −0.38, P < 0.001). Females had lower TMT than males (P < 0.001). The optimal TMT cut‐off values for predicting two‐year survival were 4.475 mm for males and 3.125 mm for females. TMT below these cut‐offs was associated with shorter survival in both univariate (HR 3.24, 95% CI 1.85–5.67) and multivariate (HR 1.86, 95% CI 1.02–3.36) analyses adjusted for age, ASA grade and bleed size. The effect of TMT on mortality was not mediated by age.ConclusionsIn patients with CSDH, TMT measurements from preoperative imaging were reliable and contained prognostic information supplemental to previously known predictors of poor outcomes.

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Sarcopenia Diagnosed Using Masseter Muscle Diameter as a Survival Correlate in Elderly Patients with Glioblastoma

Cited by 10 publications

References 36 publications

The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis

The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis

Pretreatment Masseter Muscle Volume Predicts Survival in Locally Advanced Nasopharyngeal Carcinoma Patients Treated with Concurrent Chemoradiotherapy

Reduced temporal muscle thickness predicts shorter survival in patients undergoing chronic subdural haematoma drainage

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