Sarcopenia associated with renal function in the patients with type 2 diabetes

Yang, Ruijie; Zhang, Yongze; Shen, Xiaodong; Yan, Sunjie

doi:10.1016/j.diabres.2016.06.023

Cited by 48 publications

(66 citation statements)

References 29 publications

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“…This reflects the effects of both overall diuretic use and loop diuretic use on renal function as confounders, since many of our subjects tended to have advanced renal dysfunction and needed to be treated with some class of diuretic for volume control as shown in Fig 2 . The possible association between renal function and sarcopenia is controversial; several studies have reported that decreased renal function was a risk factor for sarcopenia [ 14 , 34 – 36 ], whereas others did not find such an association, coinciding with the findings of our study [ 9 , 37 ]. We assume that one of the reasons for this discrepancy is due to the difference in the proportion of patients with advanced renal dysfunction among the studies.…”

Section: Discussionsupporting

confidence: 85%

Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease

et al. 2018

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IntroductionSarcopenia, the age-related loss of muscle mass and function, frequently accompanies chronic kidney disease. The aim of this study was to clarify the prevalence and the risk factors for sarcopenia among patients with non-dialysis-dependent chronic kidney disease (NDD-CKD), focusing on the use of drugs.MethodsWe conducted a cross-sectional analysis on a cohort of 260 patients with NDD-CKD in a university hospital, recruited between June 2016 and March 2017. We extracted data on patient gender, age, cause of chronic kidney disease, use of drugs, and comorbidities that could potentially affect the prevalence of sarcopenia. Sarcopenia was diagnosed using the criteria of the Asian Working Group for Sarcopenia. Logistic regression analysis was performed to analyze the association of each factor on the prevalence of sarcopenia.Results25.0% of our study subjects had sarcopenia. Multivariable analysis revealed that an increased risk of sarcopenia was significantly associated with age, male gender, body mass index, diabetes mellitus, and loop diuretic use (odds ratio, 4.59: 95% confidence interval, 1.81–11.61: P-value 0.001).ConclusionsIn our cohort, the prevalence of sarcopenia in patients with NDD-CKD was high, and diuretics use, particularly loop diuretic use, was suggested to be a risk factor of sarcopenia. Although loop diuretics are commonly used in patients with CKD, careful consideration of the risk of sarcopenia may be necessary.

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Section: Discussionsupporting

confidence: 85%

Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease

et al. 2018

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“…In addition, Yang et al . reported that sarcopenia was cross‐sectionally associated with a decline in renal function in people with type 2 diabetes; however, information regarding the longitudinal association between sarcopenia and decline in renal function is limited.…”

Section: Introductionmentioning

confidence: 99%

“…The third National Health and Nutrition Examination Survey showed that sarcopenia was cross-sectionally associated with an increased risk of CKD independently of hypertension, diabetes and insulin resistance in community-dwelling individuals [3]. In addition, Yang et al [4] reported that sarcopenia was cross-sectionally associated with a decline in renal function in people with type 2 diabetes; however, information regarding the longitudinal association between sarcopenia and decline in renal function is limited.…”

Section: Introductionmentioning

confidence: 99%

Sarcopenic obesity is associated with a faster decline in renal function in people with type 2 diabetes

Fukuda

Bouchi²,

Asakawa

et al. 2019

Diabet. Med.

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Aim To evaluate the association between sarcopenic obesity and the decline in estimated GFR in people with type 2 diabetes. Methods We enrolled 745 people with type 2 diabetes (mean age 64.6 years, 53.6% men). Body composition was evaluated using dual‐energy X‑ray absorptiometry. Skeletal muscle index, calculated as appendicular non‐fat mass (kg) divided by height squared (m2), was used to determine sarcopenia. Sarcopenic obesity was defined as the coexistence of sarcopenia and a ratio of android to gynoid fat mass greater than the median values in each gender. The association of sarcopenic obesity both with the annual rate of decline in estimated GFR and a >30% decline in estimated GFR was evaluated using multivariate linear regression models and Cox proportional hazard models, respectively. Results Participants with sarcopenic obesity were at an increased risk of a high annual rate of decline in estimated GFR, even after adjustment for the confounding variables (standardized β = −0.228, P <0.001). Sarcopenic obesity was also significantly associated with risk of a >30% decline in estimated GFR (hazard ratio 4.52, 95% CI 2.16–9.47; P < 0.01) in multivariate model. Conclusions Sarcopenic obesity evaluated by dual energy X‑ray absorptiometry is associated with a faster decline in renal function in people with type 2 diabetes.

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“…The progression of sarcopenia in T2D patients has been associated with lower renal function and higher urinary albumin levels [22]. As a marker of the severity of kidney disease, urinary albumin may reflect the degree of muscle weakness in patients with kidney disease.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats

Tanabe

Ogura

Kosaki

et al. 2020

Journal of Diabetes Research

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Background. Type 2 diabetes (T2D) is a known risk factor for diabetic kidney disease (DKD) and sarcopenia in older patients. Because there may be an interaction between DKD and sarcopenia, the aim of the present study is to investigate the relationship between urinary levels of liver-type fatty acid-binding protein (L-FABP) and sarcopenia using a novel rat model of T2D. Methods. Male spontaneously diabetic Torii (SDT) fatty rats (n=5) at 16 weeks of age were used as an animal model of T2D. Age- and sex-matched Sprague-Dawley (SD) rats (n=7) were used as controls. Urine samples were obtained from the rats, and muscle strength was evaluated with the use of the forelimb grip test at 16, 20, and 24 weeks of age. Serum, kidney, soleus, and extensor digitorum longus (EDL) muscle samples were collected at 24 weeks of age. Urinary L-FABP levels were measured using dedicated enzyme-linked immunosorbent assays. Results. Increased urinary L-FABP levels, focal glomerular sclerosis, moderate interstitial inflammation and fibrosis, and accumulation of renal oxidative proteins were significantly observed in the SDT fatty rats, compared to the SD rats. Muscle weight, muscle strength, cross-sectional areas of both type I and type IIb muscle fibers, and increasing rate of muscle strength were significantly decreased in the SDT fatty rats compared to the SD rats at 24 weeks. Urinary L-FABP levels at 20 and 24 weeks were significantly negatively correlated with muscle strength. Urinary L-FABP levels at 16 weeks were significantly negatively correlated with the increasing rate of muscle strength. Conclusions. Urinary L-FABP reflects the degree of muscle strength and weight, as well as cross-sectional areas of muscle fibers. Although further clinical study is needed, urinary L-FABP may be useful to monitor the progression of sarcopenia and DKD in T2D patients.

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Sarcopenia associated with renal function in the patients with type 2 diabetes

Cited by 48 publications

References 29 publications

Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease

Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease

Sarcopenic obesity is associated with a faster decline in renal function in people with type 2 diabetes

Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats

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