Sarcopenia, as defined by low muscle mass, strength and physical performance, predicts complications after surgery for colorectal cancer

Huang, Dongdong; Wang, Su‐Lin; Zhuang, Cheng‐Le; Zheng, Bailin; Lu, Jin‐Xiao; Chen, Fan‐Feng; Zhou, Chong‐Jun; Shen, Xian; Yu, Zhen

doi:10.1111/codi.13067

Cited by 199 publications

(150 citation statements)

References 29 publications

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“…According to the criteria, the diagnosis should include evaluating not only muscle mass but also functional criteria, such as muscle strength and physical performance [17]. According to Huang et al [38], the inclusion of these criteria improves the predictive value of sarcopenia for postoperative complications.…”

Section: Resultsmentioning

confidence: 99%

Nutritional and functional factors as prognostic of surgical cancer patients

Härter

Orlandi

Gonzalez

2017

Support Care Cancer

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Section: Resultsmentioning

confidence: 99%

Nutritional and functional factors as prognostic of surgical cancer patients

Härter

Orlandi

Gonzalez

2017

Support Care Cancer

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“…Comparison of sarcopenia prevalence among studies is rather difficult because of the use of different methodologies: axial CT cross-sectional imaging of SMAs, muscle mass using dual-energy X-ray absorptiometry, or a combination of anthropometric and physical performance measurements [29303132]. Furthermore, even when the same methodology is employed, different cut-offs for sarcopenia are often used (Table 5).…”

Section: Discussionmentioning

confidence: 99%

“…In patients who undergo radical gastrectomy for GC, there is a significant relationship between sarcopenia and postoperative complications [1011121330]. In a recent prospective study by Huang et al [15] including 173 elderly patients undergoing curative gastrectomy for GC, sarcopenia was predictive of higher 1-year mortality (hazard ratio [HR]=3.615; 95% CI=1.459–8.957).…”

Section: Discussionmentioning

confidence: 99%

Body Composition as a Prognostic Factor of Neoadjuvant Chemotherapy Toxicity and Outcome in Patients with Locally Advanced Gastric Cancer

et al. 2017

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PurposeNeoadjuvant chemotherapy has been shown to improve survival in locally advanced gastric cancer, but it is associated with significant toxicity. Sarcopenia and sarcopenic obesity have been studied in several types of cancers and have been reported to be associated with higher chemotherapy toxicity and morbi-mortality. The aim of this study was to assess the prevalence of sarcopenia/sarcopenic obesity in patients with gastric cancer, as well as its association with chemotherapy toxicity and long-term outcomes.Materials and MethodsA retrospective analysis was performed using an academic cancer center patient cohort diagnosed with locally advanced gastric cancer between January 2012 and December 2014 and treated with neoadjuvant chemotherapy. We analyzed body composition (skeletal muscle and visceral fat index) in axial computed tomography images.ResultsA total of 48 patients met the inclusion criteria. The mean age was 68±10 years, and 33 patients (69%) were men. Dose-limiting toxicity was observed in 22 patients (46%), and treatment was terminated early owing to toxicity in 17 patients (35%). Median follow-up was 17 months. Sarcopenia and sarcopenic obesity were found at diagnosis in 23% and 10% of patients, respectively. We observed an association between termination of chemotherapy and both sarcopenia (P=0.069) and sarcopenic obesity (P=0.004). On multivariate analysis, the odds of treatment termination were higher in patients with sarcopenia (odds ratio=4.23; P=0.050). Patients with sarcopenic obesity showed lower overall survival (median survival of 6 months [95% confidence interval {CI}=3.9–8.5] vs. 25 months [95% CI=20.2–38.2]; log-rank test P=0.000).ConclusionsSarcopenia and sarcopenic obesity were associated with early termination of neoadjuvant chemotherapy in patients with gastric cancer; additionally, sarcopenic obesity was associated with poor survival.

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“…Therefore, the application is limited to individuals who have had CT scans completed as part of their medical treatment. To date, most published research using CT scans for body composition assessment is retrospective and has been conducted in cancer populations, 12 – 16 but recent work has extended this to other clinical populations 17 – 23 …”

Section: Ctmentioning

confidence: 99%

The Use of Technology for Estimating Body Composition

et al. 2016

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Assessment of body composition, both at single time points and longitudinally, is particularly important in clinical nutrition practice. It provides a means for the clinician to characterize nutrition status at a single time point, aiding in the identification and diagnosis of malnutrition, and to monitor changes over time by providing real-time information on the adequacy of nutrition interventions. Objective body composition measurement tools are available clinically but are often underused in nutrition care, particularly in the United States. This is, in part, due to a number of factors concerning their use in a clinical context: cost and accessibility of equipment, as well as interpretability of the results. This article focuses on the factors influencing interpretation of results in a clinical setting. Body composition assessment, regardless of the method, is inherently limited by its indirect nature. Therefore, an understanding of the strengths and limitations of any method is essential for meaningful interpretation of its results. This review provides an overview of body composition technologies available clinically (computed tomography, dual-energy x-ray absorptiometry, bioimpedance, ultrasound) and discusses the strengths and limitations of each device.

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Sarcopenia, as defined by low muscle mass, strength and physical performance, predicts complications after surgery for colorectal cancer

Abstract: Sarcopenia and previous abdominal surgery are independent risk factors for complications after surgery for colorectal cancer. Including a functional aspect to the definition of sarcopenia may result in a better prediction of postoperative complications.

Cited by 199 publications

References 29 publications

Nutritional and functional factors as prognostic of surgical cancer patients

Nutritional and functional factors as prognostic of surgical cancer patients

Body Composition as a Prognostic Factor of Neoadjuvant Chemotherapy Toxicity and Outcome in Patients with Locally Advanced Gastric Cancer

The Use of Technology for Estimating Body Composition

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