Sarcopenia as an independent prognostic factor in patients with metastatic colorectal cancer: A retrospective evaluation

Cunha, Lorena Pires da; Silveira, Marina Nogueira; Mendes, Maria Carolina Santos; Costa, Felipe Osório; Macedo, Lígia Traldi; Siqueira, Nádia Sclearuc de; Carvalheira, José Barreto Campello

doi:10.1016/j.clnesp.2019.04.004

Cited by 54 publications

(71 citation statements)

References 28 publications

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“…Sarcopenia has been increasingly recognized not only as a prognosticator of adverse outcomes but also as a predictor of post-operative morbidity. 7,31,32,[35][36][37] Even in CRC, the negative impact of sarcopenia on survival has been increasingly investigated. [38][39][40] Intramuscular fat accumulation, referred to as 'myosteatosis', is an early change within the muscle architecture, associated with significantly decreased muscle quality.…”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysis

Lee

Kang

2020

J cachexia sarcopenia muscle

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Background Myosteatosis has been reported to be a novel biomarker that could predict survival outcomes in patients with colorectal cancer. However, results have been conflicting. This systematic review and meta-analysis aimed to evaluate the long-term impact of myosteatosis on the survival of these patients. Methods A systematic search of PubMed, Embase, and Cochrane up to 27 November 2019 generated 7022 records. Studies that reported hazard ratio (HR) for overall survival, cancer-specific survival, or disease-free survival based on myosteatosis or radiodensity were included. A total of 110 full-text articles were considered for inclusion, and 14 were selected for qualitative analysis. Inverse variance method was used with random effects model for data analysis. Results The total number of enrolled patients included in the meta-analysis was 6518 for univariate and 8572 for multivariate HR analysis, from 12 and 10 studies, respectively. Patients with myosteatosis had a significant increase in overall mortality compared with non-myosteatosis patients by both univariate analysis [

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Section: Discussionmentioning

confidence: 99%

Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysis

Lee

Kang

2020

J cachexia sarcopenia muscle

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“…[9][10][11][12] Pretreatment imaging also carries significance as a biomarker, with recent studies revealing that several sarcopenia indexes quantified using computed tomography (CT) images correlate well with oncologic outcomes in advanced cancer. [13][14][15] Recently, the psoas muscle index (PMI), which indicates the degree of skeletal muscle atrophy, has attracted attention for the purpose of assessing the severity of cancer-induced sarcopenia. 13,16 Thus, various indicators reflecting cancer severity affecting the general condition or sarcopenia have been identified, whereas their significance has continued to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia as a Predictor of Survival Among Patients With Organ Metastatic Cervical Cancer

et al. 2020

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Background: This study was conducted to investigate the prognostic significance of sarcopenia in patients with organ metastatic cervical cancer. Methods: Accordingly, the data of 40 patients with organ metastatic cervical cancer treated at our institute from December 2004 to December 2017 were retrospectively analyzed. The correlation between clinicopathological characteristics and survival was then evaluated using univariate and multivariate analyses. Psoas muscle index (PMI), calculated from the psoas muscle area at the L3 vertebral-body level using computed tomography images obtained for pretreatment evaluation, was adopted as an index of sarcopenia. Results: The median follow-up period was 14 months (range, 1-91 months). Kaplan-Meier analysis showed a 3-and 5-year overall survival (OS) rate of 46.1% and 35.8% for all patients, respectively. Receiver operating characteristic curve maximizing the area under the curve showed that the optimal PMI for predicting 1-year survival was 3.72 cm 2 /m 2. Patients with a PMI > 3.72 cm 2 /m 2 had significantly better OS than those with a PMI ≤ 3.72 cm 2 /m 2 (P = .046). Multivariate analysis revealed that only PMI was significantly associated with OS in patients with organ metastatic cervical cancer. Furthermore, patients with a PMI > 3.72 cm 2 /m 2 who underwent concurrent chemoradiotherapy (CCRT) had a longer OS than those receiving other therapies (P < .001). Conclusions: High PMI was determined to be a favorable prognostic factor for patients with organ metastatic cervical cancer. Moreover, patients with organ metastatic cervical cancer who have a PMI > 3.72 cm 2 /m 2 may benefit from CCRT as an initial treatment.

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“…What's worse, the loss of skeletal muscle could further cause local in ammation, contributing to increasing systemic in ammation [17]. Some studies demonstrated association between skeletal muscle mass and systemic in ammatory markers in many cancers [20][21][22][23]. These correlations provide the solid basis of in ammation mechanism responsible for sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia as a novel prognostic factor in the patients of primary localized gastrointestinal stromal tumor

Dong²

2020

Preprint

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Abstract Background : Sarcopenia predicts poor prognosis of a variety of gastrointestinal malignancies. However, there is a lack of study on the association between skeletal muscle index (SMI) and the prognosis of gastrointestinal stromal tumor (GIST). The aim of this study is to develop a novel nomogram based on sarcopenia for GIST patients to predict overall survival (OS) Methods : SMI was measured by computed tomography scan of 107 patients who underwent resection for primary localized gastrointestinal stromal tumor (GIST). Sarcopenia was defined by cutoff values for SMI as 40.1cm 2 /m 2 and 39.8 cm 2 /m 2 using optimum stratification for males and females respectively. Factors were included in the nomogram were specified by univariate and multiple Cox proportional hazard analysis. Concordance index (C-index) and calibration curves were conducted to measure the discrimination and accuracy of the nomogram. The utility of the nomogram was assessed by the decision curve analysis (DCA). Results: Twenty-eight (26.2%) of 107 patients were sarcopenic. Sarcopenia was correlated significantly with BMI, albumin, female sex, resection style, mitotic index, rupture status, survival. Sarcopenia was significantly related to decreased overall survival (p=0.003).The nomogram including sarcopenia status, resection style and mitotic index had an excellent discrimination with C-index 0.794. The calibration curves represented a good accordance between the actual observation and nomogram prediction for overall survival. Decision curve analysis illustrated that the nomogram was helpful in clinic . Conclusions: we developed a nomogram based on sarcopenia to predict overall survival after resection of GISTs which is an effective and favorable prognostication tool.

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Sarcopenia as an independent prognostic factor in patients with metastatic colorectal cancer: A retrospective evaluation

Cited by 54 publications

References 28 publications

Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysis

Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysis

Sarcopenia as a Predictor of Survival Among Patients With Organ Metastatic Cervical Cancer

Sarcopenia as a novel prognostic factor in the patients of primary localized gastrointestinal stromal tumor

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