Sarcopenia and visceral obesity assessed by computed tomography are associated with adverse outcomes in patients with Crohn's disease

Grillot, Julienne; d’Engremont, Christelle; Parmentier, Anne-Laure; Lakkis, Zaher; Piton, Gaël; Cazaux, Diane; Gay, Claire; Billy, M. de; Koch, Stéphane; Borot, Sophie; Vuitton, Lucine

doi:10.1016/j.clnu.2020.01.001

Cited by 74 publications

(81 citation statements)

References 39 publications

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“…Indeed, many studies support the active role of mesenteric fat creeping in the pathophysiology and clinical course of CD. Grillot et al described the association between sarcopenia and visceral obesity assessed by computed tomography (CT) with adverse outcomes in severe CD patients, supporting the hypothesis that the human fat is considered as a dynamic tissue involved in the immunity regulation and consequent inflammation response (111).…”

Section: Human Studiesmentioning

confidence: 93%

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Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure

et al. 2021

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Sarcopenia represents a major health burden in industrialized country by reducing substantially the quality of life. Indeed, it is characterized by a progressive and generalized loss of muscle mass and function, leading to an increased risk of adverse outcomes and hospitalizations. Several factors are involved in the pathogenesis of sarcopenia, such as aging, inflammation, mitochondrial dysfunction, and insulin resistance. Recently, it has been reported that more than one third of inflammatory bowel disease (IBD) patients suffered from sarcopenia. Notably, the role of gut microbiota (GM) in developing muscle failure in IBD patient is a matter of increasing interest. It has been hypothesized that gut dysbiosis, that typically characterizes IBD, might alter the immune response and host metabolism, promoting a low-grade inflammation status able to up-regulate several molecular pathways related to sarcopenia. Therefore, we aim to describe the basis of IBD-related sarcopenia and provide the rationale for new potential therapeutic targets that may regulate the gut-muscle axis in IBD patients.

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Section: Human Studiesmentioning

confidence: 93%

“…Interestingly, the visceral to subcutaneous adipose tissue area ratio has been considered as a biomarker of complications of CD, such as stricture and fistula ( 111 ).…”

Section: Studies Exploring Ibd and Sarcopeniamentioning

confidence: 99%

Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure

et al. 2021

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“…In the last decades, the prevalence of CD has increased continuously worldwide, especially in the developed countries, primarily due to environmental factors, such as changes in dietary patterns and alterations in body composition [1]. Among these, the loss of muscle mass resulting in a decrease of muscle strength, a condition named sarcopenia, is an increasingly prevalent condition in patients with CD and is a strong independent predictor factor for the appearance of major postoperative complications [3].…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together

Palmese¹,

Toro

Marzio

et al. 2021

Nutrients

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Sarcopenia is a prevalent condition in patients with Crohn’s disease (CD), representing an independent predictor factor for the development of major postoperative complications. Thus, a proper assessment of the muscle strength, by using different validated tools, should be deemed an important step of the clinical management of these patients. Patients with CD are frequently malnourished, presenting a high prevalence of different macro- and micro-nutrient deficiencies, including that of vitamin D. The available published studies indicate that vitamin D is involved in the regulation of proliferation, differentiation, and regeneration of muscle cells. The relationship between vitamin D deficiency and sarcopenia has been extensively studied in other populations, with interesting evidence in regards to a potential role of vitamin D supplementation as a means to prevent and treat sarcopenia. The aim of this review was to find studies that linked together these pathological conditions.

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“…Sarcopenia is a syndrome characterized by a reduction in skeletal muscle mass and function (1). Recently, increasing evidence has shown that sarcopenia assessed by a third lumbar (L3) computed tomography (CT) slice can be a prognostic predictor in digestive tract cancer and inflammatory bowel disease (IBD) (1,2). Skeletal muscle depletion is the major characteristic of sarcopenia, and many studies have also demonstrated that skeletal muscle depletion is associated with poor outcomes after surgery (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, increasing evidence has shown that sarcopenia assessed by a third lumbar (L3) computed tomography (CT) slice can be a prognostic predictor in digestive tract cancer and inflammatory bowel disease (IBD) (1,2). Skeletal muscle depletion is the major characteristic of sarcopenia, and many studies have also demonstrated that skeletal muscle depletion is associated with poor outcomes after surgery (1,2). According to the mechanisms of sarcopenia in various diseases, muscle protein synthesis is affected by inflammatory cytokines, such as interleukin-6 (3).…”

Section: Introductionmentioning

confidence: 99%

Creatinine-to-cystatin C ratio as a marker of skeletal muscle mass for predicting postoperative complications in patients undergoing gastric cancer surgery

Gao¹,

Liang²,

Qian³

et al. 2021

Ann Palliat Med

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Background: Gastric cancer patients usually suffer from skeletal muscle depletion. The serum creatinine/ cystatin C ratio (CCR) is a new, simple tool that could serve as a biomarker of skeletal muscle mass. This study explored the ability of the preoperative CCR to predict postoperative complications in patients with gastric cancer.Methods: A total of 309 patients with gastric cancer who were undergoing surgery were enrolled in this study. Univariate analyses were conducted to determine the potential risk factors for postoperative complications, and multivariate analyses were used to determine the independent influencing factors of postoperative complications. A receiver operating characteristic curve was conducted to identify the optimal cutoff value of the CCR. Patients were divided into two groups according to the critical value to investigate the relationship between the CCR and postoperative complications.Results: Postoperative complications occurred in 87 patients. Multivariate analysis suggested that age, red blood cell level, lymphocyte count, cystatin C, CCR, and N factor were independent risk or protective factors for postoperative complications (P<0.001). The optimal cutoff value of the preoperative CCR was 7.117. Compared with the high preoperative CCR group, patients with a low preoperative CCR were more likely to have both mild complications (P<0.001) and major complications (P<0.001). Conclusions:The preoperative CCR can effectively predict postoperative complications in gastric cancer patients after surgery.

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Sarcopenia and visceral obesity assessed by computed tomography are associated with adverse outcomes in patients with Crohn's disease

Cited by 74 publications

References 39 publications

Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure

Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure

Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together

Creatinine-to-cystatin C ratio as a marker of skeletal muscle mass for predicting postoperative complications in patients undergoing gastric cancer surgery

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