Sarcopenia and Sarcopenic Obesity and Osteoarthritis: A Discussion among Muscles, Fat, Bones, and Aging

Spanoudaki, Maria; Giaginis, Constantinos; Mentzelou, Maria; Bisbinas, Alexia; Solovos, Evangelos; Papadopoulos, Konstantinos; Paliokas, Ioannis; Zidrou, Christiana; Cheimaras, Antonis; Hassapidou, Maria; Papadopoulos, Athanasios N.; Papadopoulou, Sousana K.

doi:10.3390/life13061242

Cited by 8 publications

(10 citation statements)

References 79 publications

(128 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to previous studies, bone, muscle, and fat tissue are connected and interact with each other through molecules. And SP seems to have a bidirectional relationship with the maintenance or destruction of joint structures ( Spanoudaki et al, 2023 ). SP and OA elevate the risk of mutual development, which is one of the most important reasons for their frequent coexistence ( Peng and Zeng, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study

Jia,

Deng,

et al. 2024

Front. Genet.

View full text Add to dashboard Cite

Background: Previous studies demonstrated a controversial relationship between sarcopenia (SP) and osteoarthritis (OA) and their genetic causality is unclear. Thus, we conducted a Mendelian randomization (MR) analysis to evaluate the possible causal association between sarcopenia-related traits (appendicular lean mass (ALM), grip strength, usual walking pace) and OA.Method: We used pooled genetic data from the UK Biobank for ALM(n = 450,243), left-hand grip strength (n = 461,026), right-hand grip strength (n = 461,089) and usual walking pace (n = 459,915). Moreover, summary statistics for OA were obtained from the latest study conducted by the Genetics of Osteoarthritis Consortium, including all OA (n = 826,690), hand OA (n = 303,7782), hip OA (n = 353,388) and knee OA (n = 396,054). The primary method for estimating causal effects was the inverse-variance weighted (IVW) method, with the utilizing of false discovery rate adjusted p values (PFDR). Additional MR methods such as MR-Egger regression, MR pleiotropy residual sum and outlier (MR-PRESSO), weighted median were employed as supplementary analyses.Results: We discovered ALM (odds ratio (OR) = 1.103, 95% confidence interval (CI) = 1.052–1.156, PFDR = 2.87E-04), hand grip strength (left, IVW OR = 0.823, 95% CI = 0.712 to 0.952, PFDR = 0.020; right, OR = 0.826, 95% CI = 0.718 to 0.950, PFDR = 0.020), and usual walking pace (OR = 0.339, 95% CI = 0.204 to 0.564, PFDR = 2.38E-04) were causally associated with OA risk. In the reverse MR analysis, we identified a causal effect of OA on ALM (β = −0.258, 95% CI = −0.369 to 0.146, PFDR = 0.6.07E-06), grip strength (left, β = −0.064, 95% CI = −0.104 to 0.024, PFDR = 0.002; right, β = −0.055, 95% CI = −0.095 to 0.014, PFDR = 0.008), and usual walking pace (β = −0.104, 95% CI = −0.147 to 0.061, PFDR = 1.61E-05).Conclusion: This present study suggests an obvious causality of SP on OA, with condition exhibiting site-specific effects, while evidence was also provided for the causal effect of OA on SP.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study

Jia,

Deng,

et al. 2024

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…The genesis of sarcopenic obesity is multifaceted, encompassing age-related declines in physical activity, dietary changes, and hormonal alterations. Furthermore, systemic chronic inflammation orchestrated by adipokines accelerates muscle loss, and a higher concentration of leptin, commonly found in sarcopenic obesity, is linked to reduced muscle mass [ 55 ].…”

Section: Reviewmentioning

confidence: 99%

“…Adipokines such as leptin and adiponectin are central to the interplay between obesity, muscle mass, and joint pain. Elevated leptin can lead to insulin resistance and systemic inflammation due to leptin resistance and a decline in leptin receptor numbers [ 55 ]. Conversely, adiponectin is known to help protect muscle proteins and is typically found in lower levels in obese and insulin-resistant individuals [ 56 ].…”

Section: Reviewmentioning

confidence: 99%

Surgical Interventions for the Management of Obesity-Related Joint Pain: A Narrative Review

Alrayes,

Altawili,

Alsuabie

et al. 2024

Cureus

View full text Add to dashboard Cite

Obesity-related joint pain is a common and debilitating condition that significantly impacts the quality of life, primarily due to the excess weight straining the joints. This results in inflammation and degeneration, which can cause pain, stiffness, and difficulty moving. We aimed to comprehensively review the literature discussing surgical interventions for obesity-related joint pain. We searched across databases (PubMed, Scopus, and Cochrane Library) to identify studies published between 2000 and 2023 that assessed surgical interventions for obesity-related joint pain. This review highlights the complex interplay of mechanical, inflammatory, and metabolic factors contributing to joint pain in obese individuals, highlighting both surgical and non-surgical interventions. Non-surgical interventions include weight loss, exercise, physical therapy, and medications. Surgical interventions include bariatric surgery and joint replacement surgery. Bariatric surgery significantly reduces body weight and improves the quality of life outcomes; however, multiple studies have found no improvement or worsening of joint pain post-surgery. Total joint arthroplasty has demonstrated good improvement in pain and function outcomes based on recent meta-analyses, although risks of complications are higher in obese patients. The treatment choice for obesity-related joint pain depends on the individual patient’s circumstances. Non-surgical interventions are usually the first line of treatment. However, if these interventions are not effective, surgical interventions may be an option.

show abstract

“…3 The etiology of OA is still unknown, and its risk factors include joint degeneration and heredity, age, obesity, cumulative strain, joint trauma, and deformity. 4 With the aging of the global population, OA has imposed a substantial economic burden on patients and society. 5 Traditional Chinese exercise (TCE) is an important component of traditional sports in China.…”

Section: Introductionmentioning

confidence: 99%

Bibliometric Analysis of Research on Traditional Chinese Exercise and Osteoarthritis

Zeng,

Liu,

et al. 2024

JPR

View full text Add to dashboard Cite

Background: Osteoarthritis (OA) is a common disease in geriatric rehabilitation medicine caused by the progressive destruction of articular cartilage. Traditional Chinese exercise (TCE) is an important component of traditional sports in China and aims to stretch the musculoskeletal tract and relieve joint pain. Bibliometrics can help researchers find suitable partners and understand the research hotspots and trends in a certain field. However, there is still a lack of bibliometric analysis in the field of TCE and OA. Methods: All the literature was obtained from the Web of Science Core Collection database. The last search was performed on July 28, 2023. The bibliometric indicators, such as publications, citations, and H-index, were recorded. Bibliometrix and CiteSpace were used for visualization analysis. In addition, randomized controlled trials were included to summarize the exercise prescription of TCE for OA. Results: A total of 170 articles were included. The field of OA with TCE had great development potential and was in the rising period. The countries, institutions, and authors with the most publications were the United States, Tufts Medical Center, and Harvey WF, respectively. The most popular journal was Osteoarthritis and Cartilage. The recent burst keywords in this field were mainly "hip", "pilot", and "risk". Tai Chi was the most studied TCE with the most detailed content of exercise prescription, followed by Baduanjin and Wuqinxi. Conclusion:Our study provides a basis for researchers in this field to choose appropriate partner and academic journals. Moreover, pain, muscle strength, and quality of life management of elderly OA patients are research hotspots in this field. The intervention of hip OA risk through TCE is expected to become a research direction for emerging teams. The TCE prescription we summarized can better provide researchers with more treatment details.

show abstract

Sarcopenia and Sarcopenic Obesity and Osteoarthritis: A Discussion among Muscles, Fat, Bones, and Aging

Cited by 8 publications

References 79 publications

Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study

Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study

Surgical Interventions for the Management of Obesity-Related Joint Pain: A Narrative Review

Bibliometric Analysis of Research on Traditional Chinese Exercise and Osteoarthritis

Contact Info

Product

Resources

About