Sarcopenia and post-hospital outcomes in older adults: A longitudinal study

Pérez‐Zepeda, Mario Ulises; Sgaravatti, Aldo; Dent, Elsa

doi:10.1016/j.archger.2016.10.013

Cited by 45 publications

(54 citation statements)

References 41 publications

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“…Hence, sarcopenia prevalence in community dwelling older people has been estimated at 5.3% for men and 13.3% for women according to the European Working Group on Sarcopenia in Older People (EWGSOP) definition; 5.1% for men and 11.8% for women according to the International Working Group on Sarcopenia (IWGS) definition; and 1.3% for men and 2.3% for women according to the Foundation for the National Institutes of Health (FNIH) criteria ( 6 , 7 ). Furthermore, prevalence tends to be higher in acute care hospital settings ( 1 , 8 ) with the highest prevalence in hospitalized geriatric patients, ranging between 21-46% ( 9 - 13 ).…”

Section: Introductionmentioning

confidence: 99%

“…Despite its strong prognostic value for mortality in community-dwelling elderly, and the high prevalence of sarcopenia in hospitalized geriatric patients, it is unclear to what extent sarcopenia is also associated with mortality in the hospitalized geriatric patient. The study of Cerri and colleagues ( 12 ) and Perez-Zepeda and co-workers ( 13 ) are currently the only two studies concerning mortality in sarcopenic geriatric patients admitted to respectively an acute geriatric ward and a Geriatric Management and Evaluation Unit. In their work, sarcopenia was diagnosed in 21.4% of 103 ( 12 ) and 40.1% of 172 ( 13 ) geriatric patients using the EWGSOP definition.…”

Section: Introductionmentioning

confidence: 99%

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Sarcopenia is Related to Mortality in the Acutely Hospitalized Geriatric Patient

Sipers

Blois

Schols

et al. 2019

The Journal of nutrition, health and aging

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Background Sarcopenia is defined as low skeletal muscle mass with poor physical performance, representing a strong prognostic factor for mortality in older people. Although highly prevalent in hospitalized geriatric patients, it is unknown whether sarcopenia can also predict mortality in these patients. Objective To determine the association between sarcopenia according the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP), International Working Group on Sarcopenia (IWGS), Special Interest Group of Sarcopenia, Cachexia and Wasting Disorders (SIG) and Foundation for the National Institutes of Health (FNIH) and 2-year mortality in acutely hospitalized geriatric patients. Design 81 patients (84±5 y) admitted to the acute geriatric ward participated in this study. Body composition assessment (bio-impedance, Maltron Bioscan 920-II) and physical performance tests were performed, and mortality information was retrieved through patient files. Results Prevalence rates of sarcopenia were 51% (EWGSOP), 75% (IWGS), 69% (SIG), and 27% (FNIH). Based on Cox proportional hazard ratio (HR) analysis, 2-year mortality was significantly higher in sarcopenic patients versus non-sarcopenic patients when using the EWGSOP (2-y: HR 4.310; CI-95%:2.092- 8.850; P <0.001) and FNIH criteria (2-y: HR 3.571; CI-95%:1.901-6.711; P <0.001). Skeletal muscle mass index, fat mass index, body mass index, phase angle and gait speed were significantly lower in the geriatric patients who deceased after 2 years versus those who were still alive. Cox proportional HR analyses showed that higher phase angle (HR 0.678; CI-95%:0.531- 0.864; P=0.002) and higher fat mass index (HR 0.839; CI-95%:0.758-0.928; P=0.001) significantly reduced 2-y mortality probability. Combining sarcopenia criteria and separate patient characteristics finally resulted in a model in which HRs for sarcopenia (EWGSOP and FNIH) as well as phase angle significantly predicted mortality probability. Conclusion Sarcopenia is prevalent in acutely hospitalized geriatric patients and is associated with significantly higher 2-year mortality according the EWGSOP and FNIH criteria. Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s12603-018-1134-1 and is accessible for authorized users.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sarcopenia is Related to Mortality in the Acutely Hospitalized Geriatric Patient

Sipers

Blois

Schols

et al. 2019

The Journal of nutrition, health and aging

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“…One of the most widely used definitions is by the European Working Group on Sarcopenia in Older Persons (EWGSOP): low muscle mass with low muscle strength or low physical performance [ 4 ]. Previous studies on sarcopenia in patients with hip fracture have been cross-sectional, single-center, have included few participants or have had short follow-ups [ 5 – 10 ]. The three components of EWGSOP sarcopenia have different associations with mobility after hip fracture.…”

Section: Introductionmentioning

confidence: 99%

Does sarcopenia predict change in mobility after hip fracture? a multicenter observational study with one-year follow-up

Steihaug¹,

Gjesdal

Bogen

et al. 2018

BMC Geriatr

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BackgroundPatients with hip fracture frequently have sarcopenia and are at great risk of loss of mobility. We have investigated if sarcopenia predicts change in mobility after hip fracture.MethodsThis is a prospective, multicenter observational study with one-year follow-up. Patients with hip fracture who were community-living and capable of walking before the fracture were included at three hospitals in Norway (2011–2013). The primary outcome of the study was change in mobility, measured by the New Mobility Score (NMS). Sarcopenia was determined postoperatively by anthropometry, grip strength, and NMS.ResultsWe included 282 participants and sarcopenia status was determined in 201, of whom 38% (77/201) had sarcopenia, 66% (128/194) had low muscle mass, 52% (116/222) had low grip strength and 8% (20/244) had low pre-fracture mobility (NMS < 5). Sarcopenia did not predict change in mobility (effect 0.2 points; 95% CI –0.5 to 0.9, P = 0.6), but it was associated with having lower mobility at one-year (NMS 5.8 (SD 2.3) vs. 6.8 (SD 2.2), P = 0.003), becoming a resident of a nursing home (odds ratio 3.2, 95% CI 0.9 to 12.4, P = 0.048), and the combined endpoint of becoming a resident of a skilled nursing home or death (odds ratio 3.6, 95% CI 1.2 to 12.2, P = 0.02).ConclusionsSarcopenia did not predict change in mobility in the year after hip fracture.

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“…For patients classified as having a normal hydration status based on clinical judgement, repeated mf-BIA measurement of SMM showed lower variation and, thus, better reproducibility compared to the patients with an abnormal hydration status. Low SMM and strength in geriatric patients admitted to the acute care geriatric ward is of prognostic significance [10,11,37]. Therefore, measuring SMM is relevant in the acute care geriatric ward.…”

Section: Discussionmentioning

confidence: 99%

Multifrequency bioelectrical impedance analysis may represent a reproducible and practical tool to assess skeletal muscle mass in euvolemic acutely ill hospitalized geriatric patients

et al. 2019

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Aim To study the reproducibility of skeletal muscle mass assessment using multifrequency bio-impedance analysis in acutely ill hospitalized geriatric patients. Findings Mean coefficient of variation of the three skeletal muscle mass measurements was 4.9% with excellent test-retest reliability. However, non-euvolemic patients showed a significantly larger variation and significantly lower test-retest reliability when compared to the euvolemic patients in this pilot study. Message Multifrequency bio-impedance analysis seems a reliable method to assess skeletal muscle mass during the first week of hospitalization in geriatric patients, however, clinicians should be aware that in patients with over-or dehydration measurements may better take place after hydration status is normalized.

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Sarcopenia and post-hospital outcomes in older adults: A longitudinal study

Abstract: Sarcopenia showed an independent association with 12-month post-hospital mortality in older adults. With the new recognition of sarcopenia as a medical condition with its own unique ICD-10-CM code, awareness and diagnosis of sarcopenia in clinical settings is paramount.

Cited by 45 publications

References 41 publications

Sarcopenia is Related to Mortality in the Acutely Hospitalized Geriatric Patient

Sarcopenia is Related to Mortality in the Acutely Hospitalized Geriatric Patient

Does sarcopenia predict change in mobility after hip fracture? a multicenter observational study with one-year follow-up

Multifrequency bioelectrical impedance analysis may represent a reproducible and practical tool to assess skeletal muscle mass in euvolemic acutely ill hospitalized geriatric patients

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