Sarcopenia and physical function are associated with inflammation and arteriosclerosis in community-dwelling people: The Yakumo study

Hida, Takeyuki; Imagama, Shiro; Ando, Kei; Muramoto, Akio; Ito, Kenyu; Ishikawa, Yoshimoto; Tsushima, Mikito; Nishida, Yoshihiro; Ishiguro, Naoki; Hasegawa, Yukiharu

doi:10.1080/14397595.2017.1349058

Cited by 65 publications

(42 citation statements)

References 40 publications

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“…Although we found that systemic inflammation is associated with sarcopenia in the recovery stage of stroke, the mechanisms by which post-stroke patients develop systemic inflammation are not fully understood. The presence of systemic inflammation, however, is closely associated with complications that affect prognosis, such as loss of skeletal muscle mass, [36][37][38][39] loss of muscle strength, 40) weight loss, 41,42) cachexia, [43][44][45] and all-cause mortality. 46) Although the current study was not designed to address mechanistic hypotheses, it may be speculated that the relationship between systemic inflammation and sarcopenia could reflect the involvement of underlying diseases.…”

Section: Discussionmentioning

confidence: 99%

Systemic Inflammation in the Recovery Stage of Stroke: Its Association with Sarcopenia and Poor Functional Rehabilitation Outcomes

Yoshimura

Bise²,

Nagano³

et al. 2018

PRM

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Section: Discussionmentioning

confidence: 99%

Systemic Inflammation in the Recovery Stage of Stroke: Its Association with Sarcopenia and Poor Functional Rehabilitation Outcomes

Yoshimura

Bise²,

Nagano³

et al. 2018

PRM

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“…Fatigue was defined as self-reported exhaustion and was assessed using the following question: “In the past 2 weeks, have you felt tired without a reason?” Activity level was evaluated using the following questions: “Do you engage in moderate levels of physical exercise or sports in an effort to maintain health?” “Do you engage in low levels of physical exercise in an effort to maintain health?” If participants answered “No” to both questions, they were considered to be inactive. Poor grip strength was defined as a grip strength of <26 kg in men and <18 kg in women based on the Asian Working Group for Sarcopenia criteria [18]. A slow walking speed was defined as a gait speed of <1.0 m/s [19].…”

Section: Methodsmentioning

confidence: 99%

Low Bioelectrical Impedance Phase Angle Is a Significant Risk Factor for Frailty

Tanaka

Ando

Kobayashi

et al. 2019

BioMed Research International

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The phase angle, which is measured via bioelectrical impedance analysis (BIA), is a clinically important bioimpedance parameter used for nutritional assessment and evaluating the risk of various diseases, such as locomotive syndrome (LS). It remains unclear if the phase angle is associated with frailty (fragile state of physical and mental health). We therefore examined this association in a large prospective sample. Of 1081 individuals receiving health checkups, 550 (male; 235, female; 365) were enrolled in this study. We applied the Japanese version of the Cardiovascular Health Study criteria to evaluate frailty and administered the 25-Item Geriatric Locomotive Function Scale to diagnose LS. The phase angle was measured via BIA. Multiple logistic regression analysis was used to evaluate the relationship between the phase angle and frailty. For all participants and for each sex, the phase angle was significantly lower among individuals with frailty. After controlling for age, sex, and body mass index, we found that a low phase angle was a significant risk factor of frailty. As a result of multiple regression analysis including other confounding factors, among male participants, a low phase angle was significantly related with both frailty (P = 0.015) and LS (P < 0.001), whereas among female participants, the low phase angle had a stronger association with frailty (P = 0.001) than with LS (P = 0.52). Our findings suggest that a low angle is a risk factor of frailty. Furthermore, among female participants, frailty has a stronger relation with the phase angle than does LS. Therefore, the phase angle may be considered a useful indicator of frailty that does not require lengthy or costly assessment.

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“…WC by BIA was calculated automatically using the Inbody 770 BIA device. The aSMI was calculated using the following formula: aSMI = arm and leg skeletal muscle mass (kg)/height 2 (m 2 ) [23]. WC was measured manually at the level of the umbilicus at the end of gentle expiration with the subject standing using a nonstretchable measuring tape and recorded in centimeters to the nearest millimeter [6].…”

Section: Methodsmentioning

confidence: 99%

Waist Circumference Measured by Bioelectrical Impedance Analysis Is Interchangeable with Manual Measurement: Increased Waist Circumference Is Associated with Locomotive Syndrome Risk

Tanaka

Ando

Kobayashi

et al. 2019

BioMed Research International

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Objectives The importance of preventive medicine in an aging society is increasing. Locomotive syndrome (LS) is attracting increasing attention. Recently, advances in bioelectrical impedance analysis (BIA) devices have made it possible to automatically measure waist circumference (WC). Nevertheless, there have been no reports evaluating the agreement or interchangeability between WC measured manually and using BIA. Therefore, we aimed to perform these analyses in the context of health checkups and investigated the associations with LS risk. Methods We enrolled 597 participants who underwent the following: two-step tests and stand-up tests; evaluations using a 25-question geriatric locomotive function scale for the LS risk test; anthropometric marker measurements including WC measured by manual and BIA; and measurements of total cholesterol and triglycerides. We used Bland–Altman analysis to calculate agreement and interchangeability of the WC measurement using BIA and the manual method. A statistical comparative study was then conducted between normal and LS risk groups. Subsequently, significant risk factors for LS were investigated using multivariate analysis. Results The Bland–Altman analysis showed that bias (BIA-manual) was negative overall (−2.024), for males (−1.418) and for females (−2.460), suggesting underestimation using BIA compared with manual measurements. Interchangeability was found between WC measurement by BIA and by manual methods, because the percentage error was less than 15% overall (12.3%), for males (10.2%) and for females (13.8%). Univariate analysis showed that WC was significantly higher in the LS risk group than in the normal group. Multivariate analysis adjusted for confounding factors showed that increase in WC significantly correlated with LS risk. Conclusions BIA and manual methods for measuring WC are interchangeable. The increase in WC measured by BIA was significantly associated with LS risk. It is important to continue focusing on increased WC and early detection of LS risk.

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Sarcopenia and physical function are associated with inflammation and arteriosclerosis in community-dwelling people: The Yakumo study

Cited by 65 publications

References 40 publications

Systemic Inflammation in the Recovery Stage of Stroke: Its Association with Sarcopenia and Poor Functional Rehabilitation Outcomes

Systemic Inflammation in the Recovery Stage of Stroke: Its Association with Sarcopenia and Poor Functional Rehabilitation Outcomes

Low Bioelectrical Impedance Phase Angle Is a Significant Risk Factor for Frailty

Waist Circumference Measured by Bioelectrical Impedance Analysis Is Interchangeable with Manual Measurement: Increased Waist Circumference Is Associated with Locomotive Syndrome Risk

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