Sarcopenia and obesity among patients with soft tissue sarcoma – Association with clinicopathologic characteristics, complications and oncologic outcome: A systematic review and meta-analysis

Barnes, Melissa E.; Elliott, Jessie A; McIntyre, Tom; Boyle, Ellen A.; Gillis, Amy; Ridgway, Paul F.

doi:10.1016/j.ejso.2021.04.024

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…Many reports have shown that sarcopenia is closely related to the prognosis of patients with various malignant tumors. 3,[6][7][8][9][10][11]13,[19][20][21] However, different pathological types of sarcomas are not identical in treatment and prognosis, so we conducted a study on the exact pathological type of sarcomas and drew relevant conclusions. Meanwhile, the effect of sarcopenia on the post-surgical outcomes of patients with liposarcoma undergoing en bloc compartment resection has not been reported.…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma

Zhao

Fang

et al. 2022

Preprint

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Objective This investigation aimed to explore the relationship between sarcopenia and severe postoperative complications, relapse-free survival(RFS), and overall survival(OS) in patients with retroperitoneal liposarcoma (RLPS). Material and methods This retrospective study included 72 RLPS patients (47 men, 25 women; mean age, 57.49 years, SD 10.92) who had abdominal CT exams. Clinical information was recorded, including RLPS characteristics (histologic subtypes, grade, size), laboratory assessment (ALB, PALB, A/G, Hb, SCr), relapse-free survival, overall survival, and postoperative complications. The relationships between those variables and RFS and OS were analyzed using Cox proportional hazard models. Results There were 8 severe postoperative complications (Clavien-Dindo grade > 2). The Chi-square test showed sarcopenia was associated with severe postoperative complications (P = 0.011). In multivariate analysis, sarcopenia was not associated with relapse-free survival (P = 0.574) and overall survival (P = 0.578). Conclusions Sarcopenia predicts worse surgical complications but does not affect relapse-free survival and overall survival.

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Section: Discussionmentioning

confidence: 99%

Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma

Zhao

Fang

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…However, some publications explored the relationship between sarcopenia and clinical outcomes among patients with sarcoma; one reported that there was no relationship between psoas cross-sectional area and clinical outcomes after soft tissue resection [6]. The others demonstrated that sarcopenia was independently associated with poorer long-term prognosis in sarcoma [3,[7][8][9][10][11], and lower psoas muscle attenuation was associated with higher mortality [8,12]. The advanced studies showed that sarcopenia is associated with prognostic parameters in advanced or metastatic STS and first-line therapy response [13].…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma

Zhao

Fang

et al. 2022

World J Surg Onc

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Objective This investigation aimed to explore the relationship between sarcopenia and severe postoperative complications, relapse-free survival (RFS), and overall survival (OS) in patients with retroperitoneal liposarcoma (RLPS). Material and methods This retrospective study included 72 RLPS patients (47 men, 25 women; mean age, 57.49 years, SD 10.92) who had abdominal CT exams. Clinical information was recorded, including RLPS characteristics (histologic subtypes, grade, size), laboratory assessment (ALB, PALB, A/G, Hb, SCr), relapse-free survival, overall survival, and postoperative complications. The relationships between those variables and RFS and OS were analyzed using Cox proportional hazard models. Results There were 8 severe postoperative complications (Clavien-Dindo grade > 2). The chi-square test showed sarcopenia was associated with severe postoperative complications (P = 0.011). In multivariate analysis, sarcopenia was not associated with relapse-free survival (P = 0.574) and overall survival (P = 0.578). Conclusions Sarcopenia predicts worse surgical complications but does not affect relapse-free survival and overall survival.

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Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma

Garibay,

Cruz,

Judge

et al. 2024

Journal of Surgical Oncology

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Background and ObjectivesSoft tissue sarcomas (STS) are a heterogenous group of malignancies of mesenchymal origin. Given recent data linking obesity as well as the pattern of fat distribution with cancer outcomes, we sought to investigate the association of visceral fat area (VFA) and subcutaneous fat area (SFA) with oncologic outcomes in patients with STS undergoing surgery.MethodsWe analyzed data from 88 patients with STS diagnosed from 2008 to 2022. Predictor variables included body mass index (BMI), VFA, and SFA. VFA and SFA were obtained from computed tomography of the abdomen and pelvis. Univariable and multivariable Cox regression analysis was used to analyze associations between predictor variables and overall survival and recurrence‐free survival.ResultsAlthough BMI was closely correlated with VFA (r = 0.69, p < 0.0001) and SFA (r = 0.80, p < 0.0001), there was no significant association between high BMI, VFA or SFA, and worse oncologic outcomes.ConclusionsAlthough VFA and SFA are strongly correlated with BMI, we did not observe BMI nor imaging metrics of fat composition to be associated with worse oncologic outcomes. Further research is needed to elucidate any links between body fat content and metabolic or immune factors governing oncologic outcomes in STS.

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Sarcopenia and obesity among patients with soft tissue sarcoma – Association with clinicopathologic characteristics, complications and oncologic outcome: A systematic review and meta-analysis

Cited by 5 publications

References 35 publications

Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma

Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma

Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma

Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma

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