Sarcopenia and Mortality after Liver Transplantation

Englesbe, Michael J.; Patel, Shruti; He, Kevin; Lynch, Raymond; Schaubel, Douglas E.; Harbaugh, Calista M.; Holcombe, Sven A.; Wang, Stewart C.; Segev, Dorry L.; Sonnenday, Christopher J.

doi:10.1016/j.jamcollsurg.2010.03.039

Cited by 684 publications

(668 citation statements)

References 25 publications

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“…From these 28 records, eight studies assessed muscle mass with means other than CT and one study was performed in a population other than patients awaiting or undergoing liver transplantation. The remaining 19 studies, including 3803 patients in partly overlapping cohorts, were included in this systematic review (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Cross-referencing yielded no additional records.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review and Meta-Analysis of the Impact of Computed Tomography–Assessed Skeletal Muscle Mass on Outcome in Patients Awaiting or Undergoing Liver Transplantation

Vugt

Levolger

Bruin

et al. 2016

American Journal of Transplantation

283

233

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Section: Resultsmentioning

confidence: 99%

Systematic Review and Meta-Analysis of the Impact of Computed Tomography–Assessed Skeletal Muscle Mass on Outcome in Patients Awaiting or Undergoing Liver Transplantation

Vugt

Levolger

Bruin

et al. 2016

American Journal of Transplantation

283

233

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“…Sarcopenia is an age-related change, but it is also observed in young adults under certain conditions. Sarcopenia has been shown to be associated with a poor outcome, increased hospital stay, and increased treatment toxicity in several malignancies [7][8][9][10]. More recently, sarcopenia, defined by reduced muscle mass, was reported to be a significant risk factor for postoperative complications T. Sato and T. Aoyama contributed equally to this manuscript.…”

Section: Introductionmentioning

confidence: 98%

Impact of preoperative hand grip strength on morbidity following gastric cancer surgery

et al. 2015

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Background Sarcopenia is a decrease in both muscle mass and strength. It remains unclear whether sarcopenia is associated with morbidity after gastric cancer surgery. This study evaluated the impact of sarcopenia on the morbidity of gastric cancer surgery. Methods A total of 293 gastric cancer patients who underwent curative surgery between May 2011 and June 2013 were retrospectively examined. Patients with performance status 3 or 4 were excluded. Preoperative lean body mass (LBM) was evaluated by bioelectrical impedance analysis and expressed as LBM index. Preoperative muscle function was measured by hand grip strength (HGS). The cutoff values were the gender-specific lowest 20 %. Grade 2 or higher morbidities, as retrospectively evaluated by the Clavien-Dindo classification, were obtained from the patient record. The risk factors for morbidity were examined by univariate and multivariate analyses. Results Morbidity was observed in 39 patients (13.3 %), including 7 with pancreatic leakage, 12 with anastomotic leakage, and 4 with intraabdominal abscesses, but no mortality was observed. The univariate analysis showed that male gender, total gastrectomy, splenectomy, and a low HGS were significant risk factors for morbidity. A low LBM was not a significant risk factor. A low HGS, male gender, and total gastrectomy remained significant in the multivariate analysis. Conclusions A low hand grip strength was a significant risk factor for morbidity after gastric cancer surgery. The importance of the hand grip strength as a risk factor should be examined in future prospective studies.

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“…It leads to nosocomial infections [3], postoperative complications [4][5][6][7], increased length of hospital stay [7,8], and decreased survival in nonmalignant as well as malignant populations [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Skeletal muscle loss after total gastrectomy, exacerbated by adjuvant chemotherapy

et al. 2014

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Background Skeletal muscle loss is associated with physical disability, nosocomial infections, postoperative complications, and decreased survival. Preventing the loss of skeletal muscle mass after gastrectomy may lead to improved outcomes. The aims of this study were to assess changes in skeletal muscle mass after total gastrectomy (TG) and to clarify the clinical factors affecting significant loss of skeletal muscle after TG. Patients and methods One hundred and two patients undergoing TG for primary gastric cancer underwent abdominal computed tomography before and 1 year after TG to precisely quantify postoperative changes in skeletal muscle and adipose tissue. Univariate and multivariate logistic regression analyses identified clinical factors contributing to significant loss of skeletal muscle after TG.Results At 1 year after TG, the mass of both skeletal muscle and adipose tissue was reduced by 6.20 ± 6.80 and 65.8 ± 36.1 % of the preoperative values, respectively, and 26 patients (25.5 %) showed a significant loss of skeletal muscle of more than 10 %. Adjuvant chemotherapy with S-1 for C6 months (hazard ratio 26.61, 95 % confidence interval, 3.487-203.1) was identified as the single independent risk factor for a significant loss of skeletal muscle. Conclusions Skeletal muscle loss was exacerbated by extended adjuvant chemotherapy after TG. Further research should identify appropriate nutritional interventions for maintaining skeletal muscle mass and leading to improved outcomes.

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Sarcopenia and Mortality after Liver Transplantation

Abstract: Background-Surgeons frequently struggle to determine patient suitability for liver transplantation. Objective and comprehensive measures of overall burden of disease, such as sarcopenia, could inform clinicians and help avoid futile transplants.

Cited by 684 publications

References 25 publications

Systematic Review and Meta-Analysis of the Impact of Computed Tomography–Assessed Skeletal Muscle Mass on Outcome in Patients Awaiting or Undergoing Liver Transplantation

Systematic Review and Meta-Analysis of the Impact of Computed Tomography–Assessed Skeletal Muscle Mass on Outcome in Patients Awaiting or Undergoing Liver Transplantation

Impact of preoperative hand grip strength on morbidity following gastric cancer surgery

Skeletal muscle loss after total gastrectomy, exacerbated by adjuvant chemotherapy

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