Sarcopenia and malnutrition in acutely ill hospitalized elderly: Prevalence and outcomes

Cerri, A; Bellelli, Giuseppe; Mazzone, Andrea; Pittella, Francesca; Landi, Francesco; Zambon, Antonella; Annoni, Giorgio

doi:10.1016/j.clnu.2014.08.015

Cited by 166 publications

(173 citation statements)

References 27 publications

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“…The 'Low SPPB-scores' group have a fifty percent higher risk compared to the 'High SPPB-scores' group. These data of hospitalized geriatric patients confirm the results of other studies in different populations 4,10,13,15,[21][22][23] . Figure 1 gives an overview of the Kaplan Meier curves of all these significant class variables.…”

Section: Discussionsupporting

confidence: 82%

“…Especially the determinants muscle mass, muscle strength and physical performance have been found to play a major part in the increased risk of these adverse outcomes 4,5 . Also, sarcopenic patients with a diminished nutritional status have been shown to be at greater risk of dying in the shortterm 15 . In addition, comorbidities such as heart failure and orthopedic surgery can induce worse outcomes in these patients.…”

Section: Introductionmentioning

confidence: 99%

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The mortality determinants of sarcopenia and comorbidities in hospitalized geriatric patients

Lamers

Degerickx

Vandewoude

et al. 2017

JFSF

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

The mortality determinants of sarcopenia and comorbidities in hospitalized geriatric patients

Lamers

Degerickx

Vandewoude

et al. 2017

JFSF

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“…Most geriatric patients in our study were immobile and malnourished, and had an extremely low cognitive level. The negative effects of immobilization, malnutrition, and cognitive decline in our population may contribute to the serious depletion of muscle mass, leading to an extremely high prevalence of sarcopenia compared with previous studies in various clinical settings: 1-29% in communitydwelling populations, 14-33% in nursing homes, and 10-21% in acute-care hospitals (9)(10)(11).…”

Section: Discussionmentioning

confidence: 93%

“…Previous studies have reported the prevalence of sarcopenia to be 1-29% in community-dwelling populations, 14-33% in nursing homes, and 10-21% in acutecare hospitals (9)(10)(11). However, no previous studies have discussed the prevalence of and factors associated with sarcopenia among older patients at LTC hospitals.…”

mentioning

confidence: 80%

Severely Decreased Muscle Mass among Older Patients Hospitalized in a Long-Term Care Ward in Japan

Yamanouchi

Yoshimura

Matsumoto

et al. 2016

J Nutr Sci Vitaminol

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Summary Sarcopenia is known to increase the risk of adverse outcomes, including disability, loss of independence, hospitalization, longer length of hospital stay, and mortality, but there is little data about the prevalence of sarcopenia and the factors associated with increased physical dependency and cognitive decline among older patients hospitalized in a long-term care (LTC) ward in Japan. A cross-sectional study was conducted in 79 consecutive patients (34 men, 45 women) with a median age of 81 y hospitalized in an LTC hospital. Sarcopenia was defined according to the recommended algorithm of the Asian Working Group for Sarcopenia. Skeletal muscle mass index (SMI) was assessed by using bioelectrical impedance analysis. Physical dependency and cognitive decline were evaluated by the Functional Independence Measure (FIM). ) in women, showing that all participants had an SMI below the cut-off value. Seventy participants (88.6%) were unable to perform the hand grip strength test, and all participants were unable to perform the gait speed test. Multivariate analysis showed that oral nutritional access and daily energy intake were associated both with physical and cognitive level (p,0.05).

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“…Growing evidence suggests that insufficient protein, energy, and certain micronutrients intake may consequently lead to secondary sarcopenia (Cerri et al, 2015). Nutrition intake can positively impact protein synthesis; therefore, interventions for sarcopenia usually include nutrition.…”

Section: Introductionmentioning

confidence: 99%

Combining Amino Acid and Vitamin D Supplementation with Exercise Training Increases Skeletal Muscle Mass and Prevent Bone Mineral Density Loss in Participants with Low Muscle Mass

Thu

Kurose

Fukushima

et al. 2017

GJHS

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This study evaluated the impact of exercise training with amino acid and vitamin D supplementation on muscle and bone mass in participants with low muscle volume. Twenty-nine Japanese participants (56-84 years old) were enrolled and assigned into the supplement (n=15) and non-supplement (n=14) groups. All participants underwent a 6-month exercise program. Supplements and nutrition support were provided to the participants in the supplement group for 12 weeks. Body composition and whole bone mineral density (BMD) were measured using dual energy x-ray absorptiometry. The outcomes, including body composition, whole BMD, and skeletal muscle mass index (SMI), were evaluated twice: pre-and post-intervention. The SMI was 6.51(6.28; 7.14) and 5.58 (5.24; 6.05) (kg/m 2 ) in men and women, respectively. The average SMI change was 0.13% (-0.05%; 0.31%) and 2.33% (-0.88%; 5.48%); [mean (lower; upper quartile)]. The average BMD loss in the non-supplement group was -2.78%, and the BMD increased in the supplement group by 4.34%; there was an absolute difference between the two groups (p<0.05). After the intervention, serum myostatin was changed (p=0.001, non-supplement>supplement), serum vitamin D was increased (p=0.03; supplement>non-supplement), and BMD was maintained (p=0.03, supplement>non-supplement). There was a significant difference in the serum myostatin level at baseline and at 6-month in the non-supplement group, with a mean difference of 0.48 ng/ml (p=0.01). There was no significant improvement in the total lean mass, and handgrip strength. Resistance exercise combined with an amino acid supplement affects muscle and bone mass in the short-term intervention.

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Sarcopenia and malnutrition in acutely ill hospitalized elderly: Prevalence and outcomes

Cited by 166 publications

References 27 publications

The mortality determinants of sarcopenia and comorbidities in hospitalized geriatric patients

The mortality determinants of sarcopenia and comorbidities in hospitalized geriatric patients

Severely Decreased Muscle Mass among Older Patients Hospitalized in a Long-Term Care Ward in Japan

Combining Amino Acid and Vitamin D Supplementation with Exercise Training Increases Skeletal Muscle Mass and Prevent Bone Mineral Density Loss in Participants with Low Muscle Mass

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