Sarcopenia, and its association with cardiometabolic and functional characteristics in <scp>T</scp>aiwan: Results from <scp>I</scp>‐<scp>L</scp>an <scp>L</scp>ongitudinal <scp>A</scp>ging <scp>S</scp>tudy

Liu, Li-Kuo; Lee, Wei Ju; Chen, Liang-Yü; Hwang, An Chun; Lin, Ming‐Hsien; Peng, Li‐Ning; Chen, Liang Kung

doi:10.1111/ggi.12208

Cited by 68 publications

(72 citation statements)

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“…Measures of brain function were the MMSE, the Community Screening Instrument of Dementia (CSI-D), Trail Making Test (TMT) A and B, digit span and a measure of global cognitive performance (using z scores from multiple cognitive tests). The studies included the Kansas Brain Aging Project [28-30] and the MHEM study [27], both mentioned in the above section, and studies from Canada [65], Chile [67], the Chinese University of Hong Kong [69,71],Denmark [72], Italy [73], Lithuania [74], Taiwan (the I-Lan Longitudinal Aging Study, ILAS) [75], and from the USA, the Baltimore Longitudinal Study of Aging [76] and the FITKids Study [77,78]. …”

Section: Resultsmentioning

confidence: 99%

“…The I-Lan Longitudinal Aging Study is an ageing cohort study in Taiwan [75]. Within the study they performed a t test comparing mean MMSE in those with a normal relative appendicular skeletal mass (RASM = ASM/height 2 ) with those in the lowest 20% for RASM, and they found a significant difference in both men and women.…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies looked at muscle size and MMSE score, which is a useful screening tool for dementia but is not a robust test of cognitive function. Four of the studies found no association between MMSE and muscle mass [28,65,73,75] and one found an association but with a very small effect size [68]. However in one study which showed no association between MMSE and FFM, when comparing subjects with normal RASM and those within the lowest 20% of RASM this study found a significant difference in mean MMSE [75].…”

Section: Discussionmentioning

confidence: 99%

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A systematic review of the evidence that brain structure is related to muscle structure and their relationship to brain and muscle function in humans over the lifecourse

2014

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BackgroundAn association between cognition and physical function has been shown to exist but the roles of muscle and brain structure in this relationship are not fully understood. A greater understanding of these relationships may lead to identification of the underlying mechanisms in this important area of research. This systematic review examines the evidence for whether: a) brain structure is related to muscle structure; b) brain structure is related to muscle function; and c) brain function is related to muscle structure in healthy children and adults.MethodsMedline, Embase, CINAHL and PsycINFO were searched on March 6th 2014. A grey literature search was performed using Google and Google Scholar. Hand searching through citations and references of relevant articles was also undertaken.Results53 articles were included in the review; mean age of the subjects ranged from 8.8 to 85.5 years old. There is evidence of a positive association between both whole brain volume and white matter (WM) volume and muscle size. Total grey matter (GM) volume was not associated with muscle size but some areas of regional GM volume were associated with muscle size (right temporal pole and bilateral ventromedial prefrontal cortex). No evidence was found of a relationship between grip strength and whole brain volume however there was some evidence of a positive association with WM volume. Conversely, there is evidence that gait speed is positively associated with whole brain volume; this relationship may be driven by total WM volume or regional GM volumes, specifically the hippocampus. Markers of brain ageing, that is brain atrophy and greater accumulation of white matter hyperintensities (WMH), were associated with grip strength and gait speed. The location of WMH is important for gait speed; periventricular hyperintensities and brainstem WMH are associated with gait speed but subcortical WMH play less of a role. Cognitive function does not appear to be associated with muscle size.ConclusionThere is evidence that brain structure is associated with muscle structure and function. Future studies need to follow these interactions longitudinally to understand potential causal relationships.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A systematic review of the evidence that brain structure is related to muscle structure and their relationship to brain and muscle function in humans over the lifecourse

2014

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“…Taiwan, which aimed to explore the complex interrelationship between aging, frailty, sarcopenia and cognitive decline (18). People living in Yuanshan Township of I-Lan This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction.…”

Section: I-lan Longitudinal Aging Study (Ilas) Is a Community-based Amentioning

confidence: 99%

Association of Dynapenia, Sarcopenia, and Cognitive Impairment Among Community-Dwelling Older Taiwanese

Huang

Hwang

Liu

et al. 2016

Rejuvenation Research

Self Cite

118

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A decline in physical and/or cognitive function is a common feature of aging, and frailty has been shown to be associated with cognitive impairment and dementia. This study aimed to evaluate the association between dynapenia, sarcopenia, and cognitive impairment among community-dwelling older people in Taiwan. Data from the I-Lan Longitudinal Aging Study (ILAS) were retrieved for study. Global cognitive function was assessed by Mini-Mental State Examination (MMSE), whereas the Chinese Version Verbal Learning Test, Boston Naming Test, Verbal Fluency Test, Taylor Complex Figure Test, Digits Backward Test, and Clock Drawing Test were used to assess different domains of cognitive function. Association between sarcopenia and global cognitive function as well as all different dimensions of cognitive function were evaluated. Data from 731 elderly participants (mean age 73.4 ± 5.4 years, 53.8% males) were used for study analysis. The overall prevalence of sarcopenia was 6.8%, which was significantly higher in men (9.3% versus 4.1%, p < 0.05). The mean MMSE score was 23.4 ± 4.4 for all participants, and 10.3% of the study participants were cognitively impaired. Sarcopenia was not significantly associated with global cognitive function (odds ratio [OR] = 1.55, p = 0.317), but global cognitive impairment was significantly associated with low physical performance (OR = 2.31, p = 0.003) and low muscle strength (OR = 2.59, p = 0.011). Nonetheless, sarcopenia was significantly associated with impairment in the verbal fluency test (OR = 3.96, p = 0.006) after adjustment for potential confounders. Dynapenia was significantly associated with cognitive impairment in multiple dimensions and global cognitive function, but sarcopenia was only associated with an impaired verbal fluency test. Reduced muscle strength and/or physical performance related to non-muscle etiology were strongly associated with cognitive impairment. More longitudinal studies are needed.

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“…The kinanthropometry has been defined as the quantitative interface of the anatomy and physiology or between human structure and function (Vangrunderbeek et al, 2013) the human body is composed of a variety of different tissue types including lean tissues muscle, bone, and organs that are metabolically active, and fat adipose tissue that is not (Norton & Olds, 1996); In the field of medicine the assessment of body composition has been associated body fat mass content with a variety of risk factors for health and the presence of chronic degenerative pathologies (Mishra et al, 2013;Liu et al, 2014) the evolution of changes in body composition in the sedentary elderly it is manifested differently with respect to elderly people who exercise consistently (Mishra et al;Pillard et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Effect of 3-Month Water-Exercise Program on Body Composition in Elderly Women

et al. 2014

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SUMMARY:The aim of this study was to evaluate the effect of a hydrogymnastics training program on Body fat and Fatfree mass in elderly women. The subjects were randomly divided in experimental groups that participated in the hydrogymnastics training program and control group that was not involved in the training and remained sedentary. They were assessed with anthropometric variables in accordance with ISAK protocol in order to determine Body fat (Kg), Fat-free mass (Kg), the training protocol consisted of hydrogymnastics sessions 5 times per week during 12 weeks of intervention, executed in a pool of 1.3 meters divided into three phases: a 10 minute warm-up, 30 minutes of aerobic exercise at 50-60% of maximum heart rate (monitored by heart rate monitor) and a 10 minute cool down. As a statistical method to compare the results between groups of variables pre and post training, the analysis of variance (ANOVA) mixed 2 X 2 (group X measurement) test was done using SPSS version 17. The findings showed no significant increase in measurements of muscle body composition component; no significant changes in fatty tissue of body composition were observed. These results were similar and congruent with studies carried out previously in elderly adults, where physical exercise programs, during which the subjects are active for less than 30 minutes, three times a week, lead to small or no changes in body mass and body composition.

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Sarcopenia, and its association with cardiometabolic and functional characteristics in Taiwan: Results from I‐Lan Longitudinal Aging Study

Abstract: The present paper showed the epidemiology of sarcopenia, and the strong connection to functionality indicators. However, sarcopenia was not associated with cardiometabolic risk or carotid intima media thickness in the present study.

Cited by 68 publications

References 55 publications

A systematic review of the evidence that brain structure is related to muscle structure and their relationship to brain and muscle function in humans over the lifecourse

A systematic review of the evidence that brain structure is related to muscle structure and their relationship to brain and muscle function in humans over the lifecourse

Association of Dynapenia, Sarcopenia, and Cognitive Impairment Among Community-Dwelling Older Taiwanese

Effect of 3-Month Water-Exercise Program on Body Composition in Elderly Women

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