Sarcopenia and frailty in individuals with dementia: A systematic review

Waite, Samantha J.; Maitland, Stuart; Thomas, Alan; Yarnall, Alison J.

doi:10.1016/j.archger.2020.104268

Cited by 79 publications

(59 citation statements)

References 70 publications

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“…In our data from routine care, higher eGFR measures most likely represent inaccurate estimations of true GFR caused by low serum creatinine, which usually accompanies conditions of reduced muscle mass and/or chronic illness 37 . Body weight loss and malnutrition often precede dementia diagnosis 38,39 , and these conditions may also affect the eGFR estimations 40 . On the other hand, we cannot exclude the possibility that patients with eGFR≥105ml/min may de facto have glomerular hyperfiltration, and we note that the prevalence of diabetes, and diagnoses of obesity, alcohol abuse or chronic smoking (all of which have been suggested to increase the risk of glomerular hyperfiltration and dementia risk) were higher for this category 41 .…”

Section: Discussionmentioning

confidence: 99%

Kidney Function, Kidney Function Decline, and the Risk of Dementia in Older Adults

García-Ptacek

Trevisan

et al. 2021

Neurology

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Objective:Community-based reports regarding the association between the estimated glomerular filtration rate (eGFR) and dementia risk show conflicting results. This study aims is to investigate the links between kidney function, kidney function decline and dementia incidence.Methods:We analyzed the association of eGFR with the risk of dementia (defined as a new dementia diagnosis or initiation of dementia treatments) among 329,822 residents of Stockholm who accessed healthcare during 2006-2011, were ≥65 years, had no history of dementia or underwent kidney replacement therapy. We also estimated the rate of eGFR decline among 205,622 residents with repeated eGFR measurements during the first-year of observation and investigated its association with subsequent dementia risk.Results:18,983 cases of dementia (5.8% of participants) were detected over a median follow-up of 5 years. Dementia incidence rates (IR) were progressively higher with lower eGFR: from 6.56/1000 person-years in persons with eGFR 90-104ml/min to 30.28/1000 person-years in those with eGFR<30ml/min. After multivariable adjustment, lower eGFR was associated with a higher dementia risk [hazard ratio(HR), 1.71; 95% confidence interval(CI), 1.54-1.91 in eGFR 30-59ml/min and HR 2.62, 1.91-3.58 in eGFR<30ml/min] compared with eGFR of 90-104ml/min. A steeper decline in eGFR (decline>2ml/min/1.73m2/year) within one year was associated with higher dementia risk. Risk magnitudes were stronger for vascular dementia than for Alzheimer. As many as 10% (95% CI 6-14%) of dementia cases could be attributed to eGFR<60ml/min/1.73m2, a proportion higher than that attributed to other dementia risk factors such as cardiovascular disease and diabetes.Conclusions:Both lower kidney function and steeper kidney function decline are associated with the development of dementia.

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Section: Discussionmentioning

confidence: 99%

Kidney Function, Kidney Function Decline, and the Risk of Dementia in Older Adults

García-Ptacek

Trevisan

et al. 2021

Neurology

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“…Decreased physical function or physical performance has been identified as a risk factor [22]. Some diseases, such as dementia, osteoporosis, cardiovascular-related diseases, depression, obesity, and calorie or protein deficiency could also be associated with sarcopenia [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Sarcopenia among Older Adults Aged ≥65 Years Admitted to Daycare Centers of Taiwan: Using AWGS 2019 Guidelines

Chang

Yeh

Chang

et al. 2021

IJERPH

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Sarcopenia is a geriatric syndrome which is likely to cause disability, body unbalance, and mortality and thus can lead to heavy healthcare expenditure and caregiver burden. Although some studies have addressed the prevalence of sarcopenia for older adults, there are limited studies conducted in daycare centers. The present study aimed to (i) estimate the prevalence of sarcopenia and (ii) explore associated factors of sarcopenia and standing balance among older adults admitted to daycare centers in Taiwan. The cross-sectional study collected data on demographics, health status, handgrip strength, gait speed (GS), skeletal muscle mass, Taiwan-Mini Nutritional Assessment Short-Form (TW-MNA-SF), and Short Physical Performance Battery from daycare centers in northern Taiwan. The definition of sarcopenia followed the Asian Working Group for Sarcopenia 2019 guidelines. Among 173 participants ≥65 year-old, 50.9% had confirmed sarcopenia, 47.4% possible sarcopenia, and 1.7% normal. Results showed that calf circumference, TW-MNA-SF, dementia, and body mass index (BMI) were associated with sarcopenia. Moreover, BMI, GS, and sarcopenia were associated factors of standing balance. The study estimated a high prevalence of sarcopenia in daycare centers and identified some significant factors of sarcopenia and standing balance. Early nutritional and physiotherapy interventions could benefit older adults to prevent sarcopenia or unbalance.

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“…The American Medical Association refers those with 'frailty' as 'the patient group posing the most complicated and coercive problems for physicians and all health professionals' (1)(2)(3). Increased understanding among healthcare professionals regarding frailty in elderly patients may improve the follow-up and management of frail individuals.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of effect of frailty on warfarin compliance among older patients

Kiyak

Tanoğlu

Demirbaş

et al. 2021

Journal of Health Sciences and Medicine

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Aim: Warfarin has a narrow therapeutic index. We aimed to evaluate the effect of frailty on compliance to warfarin pharmacotherapy and the attainment of international normalized ratio (INR) goals in patients aged over 65 years receiving warfarin. Material and Method: We recruited 473 elderly subjects aged 65 years and over. Indications for the administration of warfarin and INR values were recorded. All patients were assessed according to the Clinical Frailty Scale of the Canadian Health and Aging Study. Whether or not the target of INR values and the degree of frailty were compared. Results: Of the 473 patients, 401 patients were assigned to the non-frail group and 72 patients were assigned to the frail group. When patients were compared according to the attainment of target INR values, a negative correlation between frailty and numerical INR values was observed. Conclusion:It can be said that the presence of frailty negatively affects reaching the target INR values in patients over 65 years of age using warfarin. If patients in this population are indicated for warfarin use, it is necessary to be sure that INR monitoring will be done well.

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Sarcopenia and frailty in individuals with dementia: A systematic review

Cited by 79 publications

References 70 publications

Kidney Function, Kidney Function Decline, and the Risk of Dementia in Older Adults

Kidney Function, Kidney Function Decline, and the Risk of Dementia in Older Adults

Prevalence and Risk Factors of Sarcopenia among Older Adults Aged ≥65 Years Admitted to Daycare Centers of Taiwan: Using AWGS 2019 Guidelines

Evaluation of effect of frailty on warfarin compliance among older patients

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