Sarcopenia and frailty as predictors of surgical morbidity and oncologic outcomes in retroperitoneal sarcoma

Nasirishargh, Aida; Grova, Monica; Bateni, Cyrus; Judge, Sean J; Nuño, Miriam A; Basmaci, Ugur Nur; Canter, Robert J.; Bateni, Sarah B.

doi:10.1002/jso.27199

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…Our results align with previous findings. 17,18,[72][73][74][75][76][77] Furthermore, our observation suggests that hypoalbuminemia identifies a high-risk cohort that may derive greater benefits from enhanced nutritional support preoperatively. The omission of descriptive statistical analysis for serum albumin and NLR, in term of patients' outcome, limits the depth of our data exploration.…”

Section: Discussionmentioning

confidence: 65%

Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcoma

Ramanovic,

Novak,

Perhavec

et al. 2024

Radiology and Oncology

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Background Retroperitoneal sarcomas (RPS) are rare tumours of mesenchymal origin, commonly presented as a large tumour mass at time of diagnosis. We investigated the impact of body composition on outcome in patients operated on for primary localized RPS. Patients and methods We retrospectively analysed data for all patients operated on for primary RPS at our institution between 1999 and 2020. Preoperative skeletal muscle area (SMA), visceral and subcutaneous adipose tissue area (VAT and SAT) and muscle radiation attenuation (MRA) were calculated using computed tomography scans at the level of third lumbar vertebra. European Working Group on Sarcopenia in Older People (EWGSOP2) criteria were applied to define myopenia. Using maximum log-rank statistic method we determined the optimal cut-off values of body composition parameters. Myosteatosis was defined based on determined MRA cut-offs. Results In total 58 patient were eligible for the study. With a median follow-up of 116 months, the estimated 5-year overall survival (OS) and local-recurrence free survival (LRFS) were 66.8% and 77.6%, respectively. Patients with myopenia had significantly lower 5-year OS compared to non-myopenic (p = 0.009). Skeletal muscle index and subcutaneous adipose tissue index predicted LRFS on univariate analysis (p = 0.052 and p = 0.039, respectively). In multivariate analysis high visceral-to-subcutaneous adipose tissue area ratio (VSR) independently predicted higher postoperative complication rate (89.2% vs. 10.8%, p = 0.008). Myosteatosis was associated with higher postoperative morbidity. Conclusions Myopenia affected survival, but not postoperative outcome in RPS. Visceral obesity, VSR (> 0.26) and myosteatosis were associated with higher postoperative morbidity. VSR was better prognostic factor than VAT in RPS.

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Section: Discussionmentioning

confidence: 65%

Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcoma

Ramanovic,

Novak,

Perhavec

et al. 2024

Radiology and Oncology

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Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma

Garibay,

Cruz,

Judge

et al. 2024

Journal of Surgical Oncology

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Background and ObjectivesSoft tissue sarcomas (STS) are a heterogenous group of malignancies of mesenchymal origin. Given recent data linking obesity as well as the pattern of fat distribution with cancer outcomes, we sought to investigate the association of visceral fat area (VFA) and subcutaneous fat area (SFA) with oncologic outcomes in patients with STS undergoing surgery.MethodsWe analyzed data from 88 patients with STS diagnosed from 2008 to 2022. Predictor variables included body mass index (BMI), VFA, and SFA. VFA and SFA were obtained from computed tomography of the abdomen and pelvis. Univariable and multivariable Cox regression analysis was used to analyze associations between predictor variables and overall survival and recurrence‐free survival.ResultsAlthough BMI was closely correlated with VFA (r = 0.69, p < 0.0001) and SFA (r = 0.80, p < 0.0001), there was no significant association between high BMI, VFA or SFA, and worse oncologic outcomes.ConclusionsAlthough VFA and SFA are strongly correlated with BMI, we did not observe BMI nor imaging metrics of fat composition to be associated with worse oncologic outcomes. Further research is needed to elucidate any links between body fat content and metabolic or immune factors governing oncologic outcomes in STS.

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Survival and prognostic factors of primary retroperitoneal sarcomas after surgery: a single-center experience

Zhao,

Zhou,

et al. 2024

Langenbecks Arch Surg

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Sarcopenia and frailty as predictors of surgical morbidity and oncologic outcomes in retroperitoneal sarcoma

Cited by 4 publications

References 34 publications

Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcoma

Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcoma

Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma

Survival and prognostic factors of primary retroperitoneal sarcomas after surgery: a single-center experience

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