Sarcomes mammaires primitifs : à propos de 30 cas traités à l’institut Salah-Azaiez de Tunis

Elhadj, O. El Amine; Nasri, Meher; Thabet, Saeed Mohamad Ahmad; Hassouna, Jamel Ben; Goucha, Aïda; Rahal, Khaled; Elmay, Ahmed; Gamoudi, Amor

doi:10.1016/j.canrad.2016.09.011

Cited by 5 publications

(7 citation statements)

References 24 publications

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“…Mastectomy has long been considered the reference treatment for PBS [ 4 , 7 , 14 , 15 ]. The radical surgical approach was inspired by the study by Berg et al.…”

Section: Discussionmentioning

confidence: 99%

Primary breast sarcomas: A 13 case-series study treated in university hospital in central Tunisia over a 25-year period

Bouguerra,

Belajouza,

Mziou

et al. 2024

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AIM: To retrospectively study the therapeutic modalities of primary breast sarcomas in view of the data of a local Tunisian experience. METHODS: It is a monocentric, descriptive, retrospective study including 13 cases of primary breast sarcoma treated over a period of 25 years (1995–2020) in the oncological radiotherapy department of a university hospital in Sousse, Tunisia. RESULTS: In our study, 13 cases of non-metastatic breast sarcomas that has been identified, divided into ten cases of phyllodes sarcomas and three cases of non-phyllodes sarcomas. Surgically, all our patients had a mastectomy. Among them, seven underwent a lymph node procedure: five underwent axillary lymph node dissection, and two others had primary axillary lymph node biopsy. For the adjuvant treatment, all the patients included in our study received radiotherapy and seven received chemotherapy. Local recurrence occurred on the operative scar in one patient after completion of radiation therapy. Metastatic relapse was described in five patients. The time to onset of metastases varied between two months and five years. Nevertheless, a complete remission was noted in 6 patients with a follow-up varying from four years to 20 years. Two patients were lost to follow-up. CONCLUSION: Breast sarcomas remain a very rare entity of aggressive tumors. The therapeutic approach is poorly codified. For this reason, the therapeutic decision should always be discussed in a multidisciplinary assessment.

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“…Mastectomy has long been considered the reference treatment for PBS [ 4 , 7 , 14 , 15 ]. The radical surgical approach was inspired by the study by Berg et al.…”

Section: Discussionmentioning

confidence: 99%

Primary breast sarcomas: A 13 case-series study treated in university hospital in central Tunisia over a 25-year period

Bouguerra,

Belajouza,

Mziou

et al. 2024

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“…Indeed, a meta-analysis supported the contribution of adjuvant chemotherapy with doxorubicin on improving the probability of survival without recurrence, however no significant effect on overall survival (8) . Following clinical trials, adjuvant chemotherapy is strongly recommended in breast sarcomas exceeding 5 cm and those of high histological grade and that by extrapolating the results observed in sarcomas of the extremities.…”

Section: Discussionmentioning

confidence: 99%

“…Following clinical trials, adjuvant chemotherapy is strongly recommended in breast sarcomas exceeding 5 cm and those of high histological grade and that by extrapolating the results observed in sarcomas of the extremities. Doxorubicin and/or ifosfamide are the most used agents in the treatment of primary breast sarcomas (8) . A new treatment option may be offered by biological treatment tests using antibodies antifacteurs growth (9) .…”

Section: Discussionmentioning

confidence: 99%

Breast Angiosarcoma.: a Case and Literature Review

Belaazri¹,

Lamine²,

Berrada³

et al. 2017

IAM

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“…34 A retrospective observational study in Tunisia enrolled 30 patients with primary breast sarcoma, 18 of whom had phyllodes sarcoma. 35 Ten patients (33%) received adjuvant doxorubicin and ifosfamide, but no data on outcomes in relation to chemotherapy alone were reported. 35 A retrospective study of 165 patients from Institut Curie in France included eight patients who received six cycles of adjuvant doxorubicin with ifosfamide for 6 cycles, but the benefit of chemotherapy remained unproven.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…35 Ten patients (33%) received adjuvant doxorubicin and ifosfamide, but no data on outcomes in relation to chemotherapy alone were reported. 35 A retrospective study of 165 patients from Institut Curie in France included eight patients who received six cycles of adjuvant doxorubicin with ifosfamide for 6 cycles, but the benefit of chemotherapy remained unproven. 36 Another study at Institut Curie included 25 patients, 13 (52%) of whom received anthracycline-based adjuvant chemotherapy; however, the authors could not determine the role of chemotherapy in overall and progression-free survival.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Phyllodes tumors of the breast treated in a tertiary health care center: case series and literature review

et al. 2018

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This study was performed to determine the subtypes of phyllodes tumor (PT) in patients at a single tertiary healthcare center in Lebanon and to describe their characteristics along with a review of the literature. Methods: This single-institution retrospective cohort study included all cases of PT of the breast treated at the American University of Beirut Medical Center from 1 January 2010 to 31 December 2014. The patients' demographic data, tumor characteristics, treatment data, and pathology reports were analyzed. Results: Thirty patients were enrolled. Their median age was 42 years. In total, 66.7% had benign disease and 22.3% had malignant disease. Twenty-seven patients underwent surgery, four received radiotherapy, and one received systemic chemotherapy after PT progression. Twenty-seven patients had no recurrence at the last follow-up, two had local recurrence, and one had metastatic disease. All three patients with recurrence had an adequate negative surgical margin at the first excision. Conclusion: This is the first cohort of patients with PT described in Lebanon and one of few in the Middle East. Our findings provide insight into the epidemiology, treatment modalities, and prognosis of PT in this geographical region.

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Sarcomes mammaires primitifs : à propos de 30 cas traités à l’institut Salah-Azaiez de Tunis

Cited by 5 publications

References 24 publications

Primary breast sarcomas: A 13 case-series study treated in university hospital in central Tunisia over a 25-year period

Primary breast sarcomas: A 13 case-series study treated in university hospital in central Tunisia over a 25-year period

Breast Angiosarcoma.: a Case and Literature Review

Phyllodes tumors of the breast treated in a tertiary health care center: case series and literature review

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