Sarcomatoid variant of urothelial carcinoma: Cytological analysis of three cases

Arita, Namie; Ishida, Mitsuaki; Yoshida, Keiko; Kagotani, Akiko; Iwamoto, Nozomi; Iwai, Muneo; Okabe, Hidetoshi

doi:10.3892/ol.2012.990

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…Arita et al [47] reported their study which included the first analysis of cytological features from a series of sarcomatoid variant of urothelial carcinoma and discussed possible differential diagnostic considerations. They analysed and reviewed the cytological features of a series of sarcomatoid variant of urothelial carcinoma cases which included 6 voided urine specimens from 3 patients with sarcomatoid variant of urothelial carcinoma.…”

Section: Discussion and Narrations From Some Of The Reported Casesmentioning

confidence: 99%

“…Arita et al [ 47 ] stated that the cytological features of sarcomatoid variant of urothelial carcinomas are not well known and only one cytological analysis of sarcomatoid variant of urothelial carcinoma had previously been reported. Arita et al [ 47 ] reported their study which included the first analysis of cytological features from a series of sarcomatoid variant of urothelial carcinoma and discussed possible differential diagnostic considerations. They analysed and reviewed the cytological features of a series of sarcomatoid variant of urothelial carcinoma cases which included 6 voided urine specimens from 3 patients with sarcomatoid variant of urothelial carcinoma.…”

Section: Discussion and Narrations From Some Of The Reported Casesmentioning

confidence: 99%

“…Arita et al [ 47 ] stated that the cytological features of 1, 2, and 3 are indistinguishable from those of conventional invasive high-grade urothelial carcinoma. Arita et al [ 47 ] postulated that these tumour cells originated from the conventional high-grade urothelial carcinoma component of sarcomatoid variant of urothelial carcinoma and this component is usually present in this type of lesion, particularly on the surface of the tumour. Moreover, the sarcomatoid component of sarcomatoid variant of urothelial carcinoma is usually present in the deeper portion of the tumour, and therefore detection of this component in the voided cytological specimen is low.…”

Section: Discussion and Narrations From Some Of The Reported Casesmentioning

confidence: 99%

See 2 more Smart Citations

Sarcomatoid Variant of Urothelial Carcinoma (Carcinosarcoma, Spindle Cell Carcinoma): A Review of the Literature

Venyo

Titi

2014

ISRN Urology

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Background. Sarcomatoid variant of urothelial carcinoma (SVUC) was added to the WHO classification in 2004. Aims. To review the literature. Materials and Method. Various internet databases were used. Result. SVUCs are rare biphasic malignant neoplasms exhibiting morphologic/immunohistochemical evidence of epithelial and mesenchymal differentiation with the presence or absence of heterologous elements. Some cases of SVUC have been associated with radiation therapy and cyclophosphamide treatment. Patients' ages range from 50 to 77 years (mean age 66). Patients tend to be younger and they more commonly presented with high-grade histology and advanced stage disease, in comparison with patients who had conventional urothelial carcinoma (CUC). Results of molecular/genetic studies strongly argue for a common monoclonal cell origin of both the epithelial and mesenchymal components in SUVC. The cancer specific survival of SVUC is poor in comparison with CUC. Radical surgical excision and chemoradiation may be associated with improved prognosis; chemoradiation as an organ preserving alternative to radical excision may be associated with improved outcome. There is no consensus opinion on the best treatment modalities for SUVC. Conclusions. SVUC is rare and is associated with inferior outcome compared with CUC. A multicentre trial of various treatment options is required. Cases of SVUC should be reported.

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Section: Discussion and Narrations From Some Of The Reported Casesmentioning

confidence: 99%

Section: Discussion and Narrations From Some Of The Reported Casesmentioning

confidence: 99%

Section: Discussion and Narrations From Some Of The Reported Casesmentioning

confidence: 99%

See 1 more Smart Citation

Sarcomatoid Variant of Urothelial Carcinoma (Carcinosarcoma, Spindle Cell Carcinoma): A Review of the Literature

Venyo

Titi

2014

ISRN Urology

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“…It is well-recognized that cytological examination of urine specimens has high sensitivity for detection of conventional high-grade urothelial carcinoma ( 10 ). Additionally, the cytological features of rare histopathological variants of urothelial carcinoma, such as micropapillary, nested and sarcomatoid, have also been described ( 11 – 16 ). However, prostate cancer cells are rarely identified in the urinary cytological specimen ( 17 ), and it has been recognized that routine examination of urine cytology for detection of prostate cancer is not recommended due to low sensitivity ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Small cell carcinoma of the urinary bladder and prostate: Cytological analyses of four cases with emphasis on the usefulness of cytological examination

et al. 2013

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The occurrence of small cell carcinoma in the urinary bladder and prostate is rare. Only a few reports on the cytological features of small cell carcinoma of the urinary bladder in the urine specimen have been documented and, moreover, the urinary cytological features of prostate small cell carcinoma have been rarely reported. In this study, we analyzed the cytological features of four cases of small cell carcinoma of the urinary bladder and prostate, and discussed the usefulness of cytological examination of urine specimen for this type of tumor. This study included two urinary bladder and two prostate small cell carcinoma cases. Analyses of the cytological features of these cases revealed the following: i) the background was mostly inflammatory and necrotic material was also occasionally observed; ii) numerous tumor cells were present in two cases, whereas only a few neoplastic cells were observed in the remaining cases; iii) the neoplastic cells were small in size, had scant cytoplasm and a high nuclear/cytoplasmic ratio, and were arranged in small clusters or occasionally as single cells; iv) the tumor cell clusters showed prominent nuclear moldings; and v) the nuclei of the neoplastic cells were round to oval in shape with finely granular chromatin containing inconspicuous nucleoli. The cytological features of small cell carcinoma in the urine specimen are characteristic. Therefore, careful observation of the urine specimen may lead to a correct diagnosis of small cell carcinoma of the urinary bladder and, moreover, cytodiagnosis of prostate small cell carcinoma may also be possible.

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“…Sarcomatoid carcinoma has been reported in a variety of organs, including the urinary bladder (11,12), kidney (13) and female genital tract (14). RPSC is an extremely rare entity, with only 14 confirmed cases reported in the literature since 1961 (1–9).…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid carcinoma of the renal pelvis: Experience of multiple cases over a ten-year period

Chen

Xia

et al. 2013

Oncology Letters

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Sarcomatoid carcinoma of the renal pelvis is a rare clinical entity. To the best of our knowledge, only 14 cases of this type of neoplasm have been reported in the literature to date. In the present study, the records at The First Affiliated Hospital, Medicine School of Zhejiang University (Hangzhou, Zhejiang, China) between 2000 and 2010 were reviewed to identify patients with primary renal pelvis sarcomatoid carcinoma (RPSC). A particular emphasis was placed on the treatment, recurrence and survival outcome. Eight patients with RPSC were identified and treated with nephrectomy or nephroureterectomy. All of the patients presented with Grade 3 RPSC. According to the TNM classification system, 2 patients were in stage pT2, 5 in stage pT3 and 1 in stage pT4. Adjuvant chemotherapy was administered to four patients, and the mean follow-up period was 27.5±41.0 months. In total, 6 patients succumbed to the disease with a mean survival time of 7.7±5.3 months (range, 1–18 months), while 2 patients were free of disease at 54 and 120 months, respectively, following treatment. The mean disease-specific survival time was 27.5±41.0 months and the 1-year recurrence-free survival, 1-year survival and overall survival rates were 37.5, 37.5 and 25%, respectively. The present analysis suggests a poor prognosis for the majority of RPSC patients, most likely resulting from the advanced stage of the disease at diagnosis and a poor response to systemic therapy. To improve the survival rate of RPSC, it is therefore essential to perform an early diagnosis and early radical surgery. Intravesical instillation is not essential following surgery.

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Sarcomatoid variant of urothelial carcinoma: Cytological analysis of three cases

Cited by 8 publications

References 10 publications

Sarcomatoid Variant of Urothelial Carcinoma (Carcinosarcoma, Spindle Cell Carcinoma): A Review of the Literature

Sarcomatoid Variant of Urothelial Carcinoma (Carcinosarcoma, Spindle Cell Carcinoma): A Review of the Literature

Small cell carcinoma of the urinary bladder and prostate: Cytological analyses of four cases with emphasis on the usefulness of cytological examination

Sarcomatoid carcinoma of the renal pelvis: Experience of multiple cases over a ten-year period

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