Sarcomatoid squamous cell carcinoma of uterine cervix: Pathology, imaging, and treatment

Kumar, Mohan; Bahl, Amit; Sharma, Daya Nand; Agarwal, Shipra; Halanaik, Dhanapathi; Kumar, Rakesh; Rath, Goura Kishore

doi:10.4103/0973-1482.39604

Cited by 11 publications

(8 citation statements)

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“…It comprises only 1-2% of all gynecological malignancies [7]. A comprehensive literature review using the terms “sarcomatoid carcinoma” and “squamous cell carcinoma” identified 20 reported cases, including a case series of nine patients (Brown et al) [4–6, 8–10]. As with the more common types of cervical cancer, HPV is the primary etiologic factor identified to date; high risk subtypes 16 and 18 have been found in both squamous and sarcomatoid components of the tumor [11].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass

Karapetyan

Manoj

Dawani

et al. 2017

Case Reports in Oncological Medicine

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Background Sarcomatoid squamous cell carcinoma is a rare and aggressive form of cervical cancer. We report a case of metastatic sarcomatoid squamous cell carcinoma (SSCC) of cervix that presented with an anterior chest wall mass. Case A 43-year-old Hispanic female presented with a two-month history of a central chest wall mass. The patient's only past medical history was SSCC of the cervix, stage IIB, diagnosed two years priorly. She underwent neoadjuvant chemoradiation therapy (CRT) with cisplatin followed by radical hysterectomy. Surgical margins were positive which led to adjuvant CRT with carboplatin and paclitaxel. PET scan 4 months after the postoperative treatment was negative for recurrence and metastatic disease. On current presentation, the CT chest revealed anterior mediastinal destructive soft tissue mass involving sternum, and the biopsy showed SSCC. The patient received palliative radiation therapy to her chest with improvement in pain and ability to swallow. After discussing the prognosis she refused further chemotherapy and decided on hospice care. Conclusion Despite good response to first-line therapy, SSCC tends to recur early and does not respond to second-line therapy. Radiation therapy seems to be the most effective modality for treatment, but randomized controlled trials of therapy are impractical.

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Section: Discussionmentioning

confidence: 99%

Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass

Karapetyan

Manoj

Dawani

et al. 2017

Case Reports in Oncological Medicine

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“…It is necessary to consider sarcomatoid squamous cell carcinoma as a possible differential diagnosis. Before epithelial-mesenchymal transition theory, i.e., the theory that carcinoma transforms into sarcoma, was widely accepted, there was some confusion about differentiating between the two diseases [ 12 ]. The traditional view was that carcinosarcoma does not exhibit merging of its carcinomatous and sarcomatous components.…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the uterine cervix arising from Müllerian ducts

et al. 2015

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Carcinosarcomas of the uterine cervix are extremely rare. Cervical carcinosarcoma can be characterized by having two different origins: the Müllerian ducts and the mesonephric duct remnants. A 53-year-old Korean woman was admitted to the hospital because of pelvic mass detected on computed tomography scan done at private clinic. A Radical hysterectomy with bilateral salpingooophorectomy and pelvic lymphadenectomy was carried out upon a diagnosis of stage IB2 cervical sarcoma. Immunohistochemically, the epithelial component was positive for pancytokeratin and estrogen receptor, but negative for CD 10 and carletinin. The mesenchymal component was positive for vimentin. The histopathologic diagnosis was a carcinosarcoma of the uterine cervix arising from Müllerian ducts. She underwent chemotherapy. She developed systemic recurrence seven months after operation and died of disease. The origin of cervical carcinosarcoma needs to be verified and immunohistochemical studies using mesonephric marker (CD 10, carletinin, and estrogen receptor) is helpful.

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“…In an English literature search for cervical sarcomatoid carcinomas, around 18 cases were found. [123] SCC has been described more frequently in the oral cavity, esophagus, pharynx, larynx and skin. Brown et al in their study have reported the largest series of 9 cases of sarcomatoid carcinomas of the cervix with a median disease-free interval of 4.9 months (2-9.5 months).…”

Section: Discussionmentioning

confidence: 99%

“…Until date, only 18 cases of sarcomatoid carcinoma of the cervix have been reported in the literature. [123] The prognosis for women with cervical sarcomatoid carcinomas tends to be worse than that of squamous histology. Patients often present with more advanced stages and follow a very aggressive course of the disease.…”

Section: Introductionmentioning

confidence: 99%

Sarcomatoid carcinoma of the cervix with foci of malignant melanoma

Shrivastava¹,

Barmon²,

Deka³

et al. 2014

J Mid-life Health

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Introduction:Sarcomatoid squamous cell carcinoma (SSCC) is a rare malignancy of the cervix. Until date around eighteen cases of SSCC have been reported in the literature. It is an aggressive tumor with poor prognosis. The tumor usually presents at an advanced stage. Similarly, primary melanomas of the uterine cervix are rare tumors with not more than 60 cases reported in the world literature. It also has a poor prognosis. There is no reported case of sarcomatoid carcinoma with malignant melanoma. Here, we are presenting a rare case of cervical carcinoma with histopathology suggestive of SSCC with foci of malignant melanoma proven by immunohistochemistry study.Case Report:The present case report is about a 42-year-old, Mrs. SR, P5 L3 D1 A1 , presented with the complaints of intermittent bleeding per vaginum since last 3 years and severe pain in the right lower limb since 1 month. On examination, there was a proliferative growth in the cervix. Her magnetic resonance imaging (MRI) showed cervical mass lesion with right parametrial extension invading the right ureter and bladder wall causing hydroureteronephrosis with contiguous bilateral pelvic nodes. There were multiple lesions in the left femur. Diagnosis of carcinoma of cervix International Federation of Gynecology and Obstetrics stage IIIB with distant metastasis was made. Histopathology report was suggestive of sarcomatoid carcinoma with foci of melanocytic melanoma. She was planned to be treated with palliative radiation.Discussion:About 90% of cervical carcinomas are squamous cell carcinoma. Adenocarcinoma constitute about 3-4% of all cervical carcinomas. Other rare pathologies are lymphoma, melanoma, sarcoma and metastatic tumors. Our case is a rare combination of sarcomatoid carcinoma with foci of malignant melanoma of cervix.

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Sarcomatoid squamous cell carcinoma of uterine cervix: Pathology, imaging, and treatment

Cited by 11 publications

References 0 publications

Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass

Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass

Carcinosarcoma of the uterine cervix arising from Müllerian ducts

Sarcomatoid carcinoma of the cervix with foci of malignant melanoma

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