Sarcomatoid malignant peritoneal mesothelioma presenting as a localized mesenteric tumor with no previous asbestos exposure

Notue, Yves Alain; Mbessoh, Ulrich Igor; Nganwa, Grace; Pambe, Judith Ngo; Mefire, Alain Chichom; Moifo, Boniface; Sando, Zacharie

doi:10.1093/jscr/rjaa419

Cited by 2 publications

(14 citation statements)

References 9 publications

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“…This study confirms that LMPeM in women is indeed a rare tumor as the 18 cases presented herein were collected in a large tertiary oncologic center over a 43-year period. This is in concordance with the English literature where 43 of such cases have been reported in a span of 26 years (1995 to 2021) 1–22,28,29. The mean and median ages were slightly higher than that reported in the literature (57 and 55 y, respectively, vs. 53.7 and 54 y, respectively) 1–22,28,29.…”

Section: Discussionsupporting

confidence: 90%

“…This is in concordance with the English literature where 43 of such cases have been reported in a span of 26 years (1995 to 2021) 1–22,28,29. The mean and median ages were slightly higher than that reported in the literature (57 and 55 y, respectively, vs. 53.7 and 54 y, respectively) 1–22,28,29. This study presents for the first time the ethnic distribution of women affected by LMPeM who were mostly Caucasians (80%), followed by African Americans (13%) and Hispanics (7%).…”

Section: Discussionsupporting

confidence: 89%

“…This contrasts with previous reports where the presentation of LMPeMs was equally distributed between abdominal pain, abdominal mass or an incidental finding. Ascites was seen in 21% of our patients and this incidence is almost identical to the 22% reported in the literature 1,4,5,7,8,11–15,17–19,21,29,30. Interestingly, our 3 patients with ascites had tumors that measured at least 6.6 cm and were located in the lower pelvis (cul-de-sac, mesosigmoid, and surrounding the femoral artery and vein).…”

Section: Discussionsupporting

confidence: 87%

“…An elevated CA125 was detected in 37.5% of our patients, and in 1 case was 1202 U/mL, which is much higher than the mild elevations, reported in prior studies (41 and 77 U/mL) 12,29. However, a comparison of the incidence and range obtained in this study and previous reports cannot be made, as most of reports on LMPeMs in the literature did not include CA125 levels 1–5,7–22,28,29. Interestingly, an elevated CA125 does not appear to correlate with tumor size, as our 5 patients with normal CA125 levels had tumors ranging from 6 to 9.6 cm.…”

Section: Discussioncontrasting

confidence: 56%

“…Localized malignant peritoneal mesothelioma (LMPeM) in women is a rare neoplasm with <50 cases reported in the English literature since 1995. Because of the rarity of this tumor and the succinctness of most reports, the amount of information available on this disease is limited 1–23. The purpose of this clinicopathologic study is to present our experience with 18 cases of LMPeM in women, the largest cohort of this entity published thus far.…”

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confidence: 99%

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Localized Malignant Peritoneal Mesothelioma (LMPeM) in Women: A Clinicopathologic Study of 18 Cases

Malpica¹,

Euscher²,

Marques‐Piubelli

et al. 2022

American Journal of Surgical Pathology

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Localized malignant peritoneal mesothelioma is a rare tumor with limited information in the literature. In this study, we present our experience with 18 cases seen in our hospital over a period of 43 years (1978 to 2021). Patients' median age was 55 years (y) (range: 33 to 79 y) and most of them were Caucasians. Patients presented with abdominal pain (11), ascites and right leg swelling (1), abdominal mass (1), and as incidental finding (1). Thirty percent of patients reported asbestos exposure, and all patients with available information had family history of tumors; a third had personal history of tumors. Seventy-seven percent had some form of abdominopelvic surgery and/or inflammatory process. Most cases had microscopic features typically seen in malignant mesothelioma; however, some cases had confounding features such as signet-ring cells, spindle cells, clear cell changes, and adenomatoid tumor-like appearance. BAP-1 by immunohistochemistry was lost in 1/3 cases. Only 1 patient underwent genetic testing and had an MSH2 germline mutation. Homozygous deletion of CDKN2A by FISH was not found in 1 tested case, although next-generation sequencing identified a CDKN2A pathogenic mutation. 16/18 (88%) had surgical treatment, and some also received adjuvant chemotherapy. The mean overall survival (OS) of our patients was 80.4 months (95% confidence interval: 54.3-106.52); the 3-year OS was 79%, while the 5-year OS was 52.6%. Fifty-three percent of patients had recurrences and 20% had tumor progression. Although the limited sample precludes definitive conclusions, small tumor size, low-grade cytology, and low mitotic index appeared to be associated with an indolent behavior.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 56%

mentioning

confidence: 99%

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