Sarcomatoid intrahepatic cholangiocarcinoma in a patient with poor prognosis: a case report and literature review

Li, Xu; Li, Jian; Liu, Kai; Tan, Ludong; Liu, Yahui

doi:10.1177/0300060520969473

Cited by 9 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Anti-tumor treatment histories, such as transarterial chemoembolization (TACE), radiofrequency ablation, and percutaneous ethanol injection have been considered as inducements or accelerators of sarcomatous change, although this possibly has not been supported by clinical cases. 4 , 5 The current thought is that sarcomatoid differentiation occurs spontaneously during tumor genesis. No specific features have been identified in the symptoms, or in the serological and imaging findings.…”

mentioning

confidence: 99%

Primary Liver Sarcomatoid Carcinoma: A Case Series and Literature Review

Xing

et al. 2021

JHC

Self Cite

View full text Add to dashboard Cite

Background: Primary liver sarcomatoid carcinoma (PLSC) is rare. To improve the understanding of PLSC, cases were described and reviewing the literature. Methods: A retrospective analysis was performed on 14 cases of PLSC diagnosed by pathology in Northeastern China from 2010 to 2020. An individual participant data analysis based on reported cases was conducted to determine epidemiological characteristics, clinical characteristics, and prognoses of PLSC. Results: A total of 136 cases involved our 14 cases and 122 cases from previous reports. The percentages of sarcomatoid hepatocellular carcinoma, sarcomatoid cholangiolocellular carcinoma, and mixed and unclassified types were 36.8%, 41.9%, 5.9%, and 15.4%, respectively. A total of 95.6% PLSC was found in Asia. There was a lower percentage of hepatitisinfected patients in Japan, when compared with the Republic of Korea (38.5% vs 70.0%, P<0.05). Five cases were initially misdiagnosed as a hepatic abscess by imaging. A total of 36.7% cases had metastases when being diagnosed, and 68.9% cases relapsed during the follow-up. The median disease-free survival and overall survival (OS) were 3 months and 5 months, respectively. Only radical surgery (hazard ratio = 0.308, 95% confidence interval 0.186-0.512, P<0.001) indicated a better OS. Conclusion: PLSC was more prevalent in Asia and there were possibilities of misdiagnoses. Surgery is still an effective treatment and can significantly prolong the OS. Only limited strategies for recurrent or advanced PLSC, immunotherapy may be possible treatment.

show abstract

mentioning

confidence: 99%

Primary Liver Sarcomatoid Carcinoma: A Case Series and Literature Review

Xing

et al. 2021

JHC

Self Cite

View full text Add to dashboard Cite

show abstract

“…Abdominal pain is the most common clinical symptom. 8 Serum CA125, CA19-9, CEA, and AFP may not be sensitive for the diagnosis of S-iCCA. The imaging features of S-iCCA are also nonspecific and usually appear as hypoattenuated or mixed-echoic masses on ultrasonography.…”

Section: Discussionmentioning

confidence: 92%

“…After analysis of the retrieved publications, 51 unrepeated S-iCCA cases were identified in 20 published studies. 1,2,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Table 1 summarizes the clinical characteristics of 52 patients (including this case). Thirty-five were male (67.3%), 17 were female (32.7%), and the average age was 61 (range: 37-87) years.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sarcomatoid Intrahepatic Cholangiocarcinoma After Immunotherapy: A Case Report and Review of the Literature

Zeng¹,

Liu²,

Yu³

et al. 2022

J Clin Transl Hepatol

View full text Add to dashboard Cite

Sarcomatoid carcinoma is a rare tumor that is composed of a mixture of malignant epithelial cells and mesenchymal cells. Many studies have reported that sarcomatoid carcinoma occurs in multiple organs including the liver. Sarcomatoid intrahepatic cholangiocarcinoma (S-iCCA) is an extremely rare tumor that primarily occurs in the liver. This case occurred in a middle-aged man who was admitted to our hospital with abdominal pain. Enhanced computed tomography of the abdomen showed a low-density mass in the upper right posterior lobe of the liver with enhancement in the periphery. Histological and immunohistochemical examination indicated that the tumor was malignant, with both cancer and sarcoma components, and was positive for cytokeratin and vimentin. The patient was diagnosed with S-iCCA. Metastases appeared in the liver and lung 4 months after surgery. Two cycles of chemotherapy were administered. Because of enlargement of the tumor, anti-angiogenic agents combined with immunotherapy were subsequently given to achieve disease control. To the best of our knowledge, this is the first reported case of a programmed cell death-1 inhibitor used in a S-iCCA patient. The purpose of this case report and literature review is to enhance clinician understanding of S-iCCA and to explore safe and effective treatment methods.

show abstract

“…According to related reports, sarcomatoid cholangiocarcinoma, a very rare tumor with pathological changes in epithelial and mesenchymal components, is highly aggressive and has poor prognosis [15]. Its diagnosis is mostly achieved through a combination of histopathological and immunohistochemical examinations.…”

Section: Discussionmentioning

confidence: 99%

Intrahepatic sarcomatoid cholangiocarcinoma with portal vein thrombus misdiagnosed as hepatocellular carcinoma: description of a rare case

Zhan

Xing

2023

Preprint

View full text Add to dashboard Cite

Less than 1% of malignant tumors of the hepatobiliary system are intrahepatic sarcomatoid cholangiocarcinomas, a rare malignant tumor of the liver. Based only on clinical presentation and imaging, this entity is readily mistaken for hepatocellular carcinoma. In this article, we describe the case of a 36-year-old male patient who had a history of "cirrhosis B" and was hospitalized for six months due to increased alpha-fetoprotein. Magnetic resonance imaging (MRI) and computed tomography (CT) revealed a 63x 90 mm mass in segments V and VI of the liver, with thrombosis in the right branch of the portal vein. Following the patient's laparoscopic lobectomy and cholecystectomy, sarcomatoid cholangiocarcinoma of the right side of the liver was discovered by histopathological and immunohistochemical examinations. This case report seeks to increase understanding of intrahepatic sarcomatoid cholangiocarcinoma and its diagnosis while reducing the occurrence of clinical misinterpretation.

show abstract

Sarcomatoid intrahepatic cholangiocarcinoma in a patient with poor prognosis: a case report and literature review

Cited by 9 publications

References 25 publications

Primary Liver Sarcomatoid Carcinoma: A Case Series and Literature Review

Primary Liver Sarcomatoid Carcinoma: A Case Series and Literature Review

Sarcomatoid Intrahepatic Cholangiocarcinoma After Immunotherapy: A Case Report and Review of the Literature

Intrahepatic sarcomatoid cholangiocarcinoma with portal vein thrombus misdiagnosed as hepatocellular carcinoma: description of a rare case

Contact Info

Product

Resources

About