Sarcomatoid carcinoma with osseous differentiation in the bladder

AbstractWe report the diagnostic evaluation, management, and intermediate-term outcomes of a rare variant of bladder cancer and concomitant Abdominal Aortic Aneurysm. A 62 year old male with gross haematuria and Abdominal Aortic Aneurysm was admitted to our hospital. Cystoscopy revealed a large bulky mass occupying the posterior bladder wall. The tumor was transurethrally resected and its histology showed a Sarcomatoid Carcinoma of the urinary bladder. Due to the aggressive behavior of the tumor and the risk of aneurysm rupture, concomitant endovascular exclusion of Aneurysm, total cystectomy with urinary diversion was performed. 12 months after radical surgery the patient was alive without any local recurrence, distant metastasis, and thrombosis of iliac axis. To our knowledge this study is the first report to describe data on the diagnostic evaluation, Management, and intermediate-term outcomes in Sarcomatoid carcinoma and Concomitant Abdominal Aortic Aneurysm. Multi-institutional collaboration is important to perform clinical trials of adequate sample size to design more effective treatments for these aggressive cancers in the presence of Concomitant Abdominal Aortic Aneurysm.

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“…At initial diagnosis, almost all patients presented frequently with the advanced stage disease and distant metastases [9].…”

Section: Discussionmentioning

confidence: 99%

“…Most patients died of local disease or of lymph node, lung, pleura, brain, liver, and bone metastases [9].…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid carcinoma of the urinary bladder and concomitant abdominal aortic aneurysm: a case report and literature review

2011

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“…Most tumors present as a single, large polypoid mass, ranging in diameter from 1.5 cm to 12 cm. 1 Grossly, these tumors tend to be polypoid and ulcerated, and most patients with carcinosarcoma of the urinary bladder have an advanced stage of the disease, with muscularis mucosa involvement typically present at the time of initial diagnosis. 1 results.…”

Section: Discussionmentioning

confidence: 99%

“…Sarcomatoid carcinoma is known to occur in only 0.3% of total bladder cancers; 1 according to domestic reports (Korea), one case was reported as a sarcomatoid carcinoma confined in the bladder, and other cases included sarcomatoid carcinomas confined in the pelvis of the kidney or in the diverticulum in the bladder. 2 Sarcoma-toid carcinomas are typically malignant with a very fast growth velocity, such that once diagnosed, most cases have a poor prognosis because the patients have already advanced to a stage at which the carcinoma has already invaded the surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

Sarcomatoid Carcinoma in the Urinary Bladder

et al. 2010

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Sarcomatoid carcinoma of the urinary bladder is a rare malignant neoplasm in which the tumor consists of both carcinomatous and sarcomatous elements. In Korea, only 1 case of bladder and renal pelvis primary sarcomatoid carcinoma and 4 cases of carcinosarcoma involving the bladder have been reported. Recently, we experienced a case of sarcomatoid carcinoma of the bladder in a 78-year-old male patient experiencing severe gross hematuria. An ultrasound demonstrated a broad-based tumor 4.5×3.6 cm in size on the lateral side of the right ureteral orifice in the bladder dome. Under the diagnosis of a bladder tumor, transurethral resection of the bladder tumor (TURBT) was performed. A subsequent histological examination of the biopsy specimens showed both malignant mesenchymal and epithelial elements. As a result, the tumor was pathologically confirmed as a primary sarcomatoid carcinoma of the urinary bladder.

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“…Sarcomatoid carcinoma is known to occur in only 0.3% of total bladder cancers (1). Approximately 80 cases have been reported in the literature and most often as a single case report.…”

Section: Introductionmentioning

confidence: 99%