Sarcomatoid carcinoma of the small intestine: a rare and highly aggressive tumor

Lee, Sang Eok; Park, Shin Young

doi:10.4174/jkss.2012.83.5.321

Cited by 20 publications

(25 citation statements)

References 10 publications

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“…The average size is about 7.5 cm with a range of 3–16 cm 8. The use of immunohistochemical markers helps in a wide range of differential diagnoses which include epithelioid angiosarcoma, leiomyosarcoma, epithelioid MPNST, GIST, lymphoma and melanoma 3. Lymphovascular invasions are found in 55% of the cases, similar to our case 8…”

Section: Discussionsupporting

confidence: 80%

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Primary sarcomatoid carcinoma of the small intestine: very rare and aggressive tumour

Andrawes¹,

Shariff

Chang

et al. 2017

BMJ Case Reports

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Sarcomatoid carcinoma of the small intestine is a very rare and aggressive variant of small intestinal cancers with poor prognosis. The tumour primarily affects middle-aged and older patients with a mean age of 57 years at the time of presentation. We report a woman aged 58 years without any relevant medical history who presented with small intestinal obstruction. She underwent radiologic and endoscopy investigation with persistent features of small bowel obstruction. The patient was found to have a small bowel tumour causing the obstruction and underwent surgical excision of the tumour. Pathology revealed malignant neoplasm with sarcomatoid and epithelioid features involving the terminal ileum. The use of immunohistochemical markers helps in wide range of differential diagnoses. Surgical resection is still considered the best and first-line therapy with poor response to chemotherapy and radiotherapy.

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Section: Discussionsupporting

confidence: 80%

“…Patients usually have different, non-specific symptoms including: abdominal pain, intestinal obstruction, as in our case presentation, palpable abdominal mass, nausea, vomiting, weight loss, GI bleeding and anaemia 3 7. Zhang et al noted that anaemia and abdominal pain have been the two most common presentations 8.…”

Section: Discussionmentioning

confidence: 73%

Primary sarcomatoid carcinoma of the small intestine: very rare and aggressive tumour

Andrawes¹,

Shariff

Chang

et al. 2017

BMJ Case Reports

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“…Symmetric or asymmetric wall thickening with fold effacement was noted in three cases (3,4,7). CT failed to detect the lesion in three cases (6,8,9).…”

Section: Index Termsmentioning

confidence: 92%

“…Further studies for comparing CT finding of biphasic and monophasic sarcomatoid carcinoma will be necessary. Small bowel series was done together with the CT in several cases (6)(7)(8)10). The study revealed the intraluminal polypoid mass (6,8,10), although CT failed to detect the lesion (6,8) or mimicked the pancreatic cancer (10).…”

Section: Index Termsmentioning

confidence: 99%

Sarcomatoid Carcinoma of the Small Intestine: A Case Report and Review of the Literature

Kang

Yoon

Kang

2013

J Korean Soc Radiol

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INTRODUCTIONBy definition, sarcomatoid carcinomas are malignant tumors that exhibit histological characteristics of a combination of malignant epithelial and mesenchymal cells. These tumors can occur in various anatomical sites, including lungs, thyroid gland, salivary gland, breast, bladder, prostate, skin and digestive system (1). Gastrointestinal sarcomatoid carcinomas are unusual tumors that occur most frequently in the stomach, gallbladder, and esophagus (1). These are especially rare in the small intestine, with an incidence of only 0.5-0.8 per 100000 population per year (2). To the best of our knowledge, only 26 cases have been reported in the English literature up to date (3-8). Moreover, most of the cases are focused on the pathologic reviews.Therefore, we present a case of sarcomatoid carcinoma arising from small intestinal tract with findings of the multi-detector computed tomography (MDCT) scans and reviews of the literature. CASE REPORTA 78-year-old man was presented at our hospital with complaints of intermittent and aggravated diffuse abdominal pains for three days. His personal history was unremarkable except for the hypertension of one month duration. Physical examination revealed a palpable mass-like lesion in right lower quadrant. The results of other laboratory investigations, including routine blood tests, liver tests, urine analysis and serum tumor marker (carcinoembryonic antigen) were within normal limits, except for the mild anemia (hemoglobin, 8.7 g/dL). The MDCT of the abdomen was performed for further evaluations on a palpable abdominal mass, including unenhanced CT scans and dynamic contrast-enhanced CT scans with a non-ionic contrast medium (Omnipaque 350, GE Healthcare, Oslo, Norway). The volume of 100 mL contrast medium was injected at a rate of 3 mL/s via an antecubital vein. The dynamic contrast-enhanced

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“…(14) In summary, sarcomatoid carcinoma is a biphasic malignant neoplasm with carcinomatous and sarcomatous components. Thus, it has a high degree of malignancy and a poor prognosis, (15) and the risk of local recurrence or distant metastases is also very high. The main radiographic and CT appearance of mandibular sarcomatoid carcinoma is diffuse, irregular osteolytic bone destruction with a soft tissue mass, generally without bone sclerosis or expansion.…”

Section: Discussionmentioning

confidence: 99%

Primary sarcomatoid carcinoma of the mandibular gingiva: clinicopathological and radiological findings

Shen

Liu²

2014

smedj

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Sarcomatoid carcinoma of the small intestine: a rare and highly aggressive tumor

Cited by 20 publications

References 10 publications

Primary sarcomatoid carcinoma of the small intestine: very rare and aggressive tumour

Primary sarcomatoid carcinoma of the small intestine: very rare and aggressive tumour

Sarcomatoid Carcinoma of the Small Intestine: A Case Report and Review of the Literature

Primary sarcomatoid carcinoma of the mandibular gingiva: clinicopathological and radiological findings

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