Sarcomas of the oral and maxillofacial region: a review of 32 cases in 25�years

Yamaguchi, Satoshi; Nagasawa, Hirokazu; Suzuki, Tetsuo; Fujii, Eijiro; Iwaki, Hiroshi; Takagi, Minoru; Amagasa, Teruo

doi:10.1007/s00784-003-0233-4

Cited by 126 publications

(111 citation statements)

References 12 publications

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“…Head and neck sarcomas are extremely rare malignancies and they make about 4% -10% of all sarcomas (27). Oral sarcomas show male preponderance with the average age of 42 years (28).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Evaluation of Palatal Cancers in Iran: A Study on 303 Cases

Akbari

Atarbashi-Moghadam

et al. 2018

Int J Cancer Manag

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Background: Palatal neoplasms may demonstrate different microscopic features compared with other anatomic area of the oral cavity, which is due to the accumulation of a large amount of salivary gland structure. Objectives: Due to lack of adequate information on malignant neoplasms of this unique anatomic site, the current study aimed at evaluating the prevalence of palatal cancers in Iranian population during a 6-year period. Methods: The files of Iran cancer registry, ministry of health and Medical education have been used as the source of the materials from 2003 to 2009 for this study. This center has been collecting data on patients with cancer from all main hospitals located in various cities of Iran. All palatal malignant lesions were recorded. Patients' gender, decades of life, and histopathologic type of cancers were evaluated. Statistical analysis was performed, using SPSS 21 software and the results with P < 0.05 were considered significant. Results: Palatal cancers accounted for 8.66% of the oral malignancies. During this period, 303 cases of palatal malignancies had been registered in this center. The majority of cases were in the 5th to 8th decades of life with male to female ratio 1.29. Salivary gland malignancies were the most common cancers in palatal region (47.19%) followed by epithelial cancers (36.3%) and non-Hodgkin lymphoma (5.94%). Conclusions: This study provided a large series of demographic data and microscopic variations of palatal cancers in Iran, which may contribute to precise diagnosis and better treatment of these malignancies.

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“…Head and neck sarcomas are extremely rare malignancies and they make about 4% -10% of all sarcomas (27). Oral sarcomas show male preponderance with the average age of 42 years (28).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Evaluation of Palatal Cancers in Iran: A Study on 303 Cases

Akbari

Atarbashi-Moghadam

et al. 2018

Int J Cancer Manag

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“…In a systematic review of 201 patients with craniofacial osteosarcoma Smeele et al (8) have reported improved survival with complete resection and adjuvant chemotherapy. Early radical resection was also recommended as the primary treatment with the aim of local control in two recent series of patients with head and neck sarcomas especially located in the maxillofacial region (9,10).…”

Section: Discussionmentioning

confidence: 99%

Maxillofacial osteosarcoma successfully treated with surgery and adjuvant chemotherapy in a child

Küpeli¹,

Varan²,

Akyüz³

et al. 2012

BLL

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Maxillofacial osteosarcoma constitutes a minor percentage of all the head and neck tumors. We describe a 10 year-old girl presenting with swelling and pain in left maxillary region and diagnosed as low grade osteosarcoma. The patient was operated and given a chemotherapy protocol consisted of Cisplatin and Doxorubicin. After six courses of chemotherapy the patient was in complete remission and she is well with no evidence of disease for fi ve years. Since high local recurrence rates have been reported in craniofacial osteoarcoma and we know the deleterious side effects of radiation therapy in children, we believe that best management strategy for osteosarcomas in maxillofacial region in children is radical surgical excision and postoperative chemotherapy (Fig. 3 Osteosarcoma is a primary malignant tumor of bone, deriving from primitive bone-forming mesenchyme and constitutes the most common malignant bone tumor of the childhood. Although primary bone tumors are rare in childhood they are sixth most common group of malignant neoplasms in children. The tumor occurs most frequently in the long bones, especially around the knee (1). Maxillofacial osteosarcoma constitutes a minor percentage of all the head and neck tumors (2). We describe a child with osteosarcoma located in maxillofacial area with a review of treatment modalities. CaseA 10 year-old girl was admitted to another hospital for pain and swelling in left part of the upper jaw. Despite aspiration of the swelling and antibiotic therapy the complaints of the patient continued. After biopsy of the left palatinal region pathologic examination had been reported as osteoblastoma. The parents brought the child to our hospital for treatment.On physical examination there was a swelling in her left maxillary region. The computed tomography (CT) of the paranasal sinuses (Fig. 1) revealed an ill-defi ned and expansive mass at the left maxillary alveolar process, extending to the palate and to the maxillary sinus. The mass had a diameter of 3.5 cm, had chondrogenic matrix and was causing bone destruction The CT of the chest was normal. Bone scintigraphy with 99mTc-MDP demonstrated no metastasis.Maxillar biopsy taken by otolaryngology department revealed mesenchymal neoplasia. Subsequent left inferior maxillectomy revealed low grade osteosarcoma and tumoral cells in surgical margin (Fig. 2). During the surgery a mass of approximately 3x4 cm was seen in hard palate, at the left of the midline. Hard palate was extracted with inferior nasal concha and fl oor of the nose. An obturator prosthesis was inserted to the palatal defect.In the patient a chemotherapy protocol was started consisting of Cisplatin (120 mg/ m 2 ) on day 1, and Doxorubicin (30 mg/ m 2 ) on days 1-3 with three weeks interval. After six courses of

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“…Both rhabdomyosarcoma patients developed distant lung metastasis and succumbed to their disease within 2 years of their first visits. In a review of sarcomas of the oral and maxillofacial region, Yamaguchi et al (20) reported that 3 of 5 rhabdomyosarcoma cases died within 3 years after treatment and that distant metastasis occurred in the deceased but not in the surviving and disease-free patients. These observations strongly indicate that distant metastasis is a major complication contributing to the poor outcome in patients with rhabdomyosarcoma and malignant melanoma.…”

Section: Distant Metastasis -----------------------------------Clinicmentioning

confidence: 99%

Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non-squamous cell carcinoma

Shiiba

Unozawa

Higo

et al. 2014

Molecular and Clinical Oncology

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Abstract. The objective of this study was to elucidate the clinical characteristics of uncommon head and neck malignancies, such as non-squamous cell carcinoma (SCC), in order to improve patient outcomes. A total of 463 head and neck malignancies were retrospectively analyzed, with 43 cases (9.3%) diagnosed as non-SCC. The overall survival rate of patients with adenoid cystic carcinoma was significantly worse compared to that of patients with SCC. The 5-year survival rates were <50% for patients with malignant melanoma, adenocarcinoma, small-cell carcinoma and sarcomas. Distant metastasis to the lung was frequently observed in cases with a poor outcome. Non-SCC malignancies treated without surgery were associated with a worse outcome. Some non-SCC patients had a poor prognosis and distant metastasis was associated with an unsatisfactory outcome. Timely treatment and control of distant metastasis are essential and surgical treatment should be prioritized in non-SCC cases to improve patient outcomes.

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Sarcomas of the oral and maxillofacial region: a review of 32 cases in 25�years

Cited by 126 publications

References 12 publications

Epidemiological Evaluation of Palatal Cancers in Iran: A Study on 303 Cases

Epidemiological Evaluation of Palatal Cancers in Iran: A Study on 303 Cases

Maxillofacial osteosarcoma successfully treated with surgery and adjuvant chemotherapy in a child

Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non-squamous cell carcinoma

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