Sarcomas of the Kidney

Srinivas, V.; Sogani, Pramod C.; Hajdu, Steven I.; Whitmore, Willet F.

doi:10.1016/s0022-5347(17)49441-9

Cited by 90 publications

(47 citation statements)

References 20 publications

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“…Leiomyosarcoma is the most common renal sarcoma, which accounts for 40-60% of reported cases, followed by rhabdomyosarcoma, malignant fibrous histiocytoma, fibrosarcoma, angiosarcoma, hemangiopericytoma, liposarcoma, chondrosarcoma and osteosarcoma (9)(10)(11)(12). Although the origin is unknown, synovial sarcoma is a well defined clinical and pathologic tumor type that mainly develops in juxtaarticular soft tissue or in the limbs of young people and adults (1).…”

Section: Discussionmentioning

confidence: 99%

A Case of Renal Synovial Sarcoma Treated with Adjuvant Ifosfamide and Doxorubicin

Özkan

Mertsoylu²,

Özardalı

2011

Intern. Med.

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Primary renal synovial sarcomas (SS) are rare tumors of the kidney. Faria et al first described primary renal synovial sarcoma in 1999 ( Mod Pathol 12:94A). In this paper we present a primary renal synovial sarcoma case and review the 41 primary renal synovial sarcoma cases reported to date. Primary renal synovial sarcomas can exist in either a monophasic or a biphasic pattern. The monophasic variant of primary renal synovial sarcoma is more common and tends to have a better prognosis than the biphasic variant. We present in this paper, a 68-year-old woman with primary renal synovial sarcoma. She presented with right flank pain and abdominal distention. Postoperative pathology of the 20 cm mass on magnetic resonance imaging showed histologic and immunochemical features of synovial sarcoma with coexisting spindle and epithelial cells. She underwent adjuvant ifosfamide and doxorubicin chemotherapy and was free of disease at 1 year after diagnosis. As a conclusion, physicians should be aware of the possibility of malignancy in cystic renal masses and that synovial sarcoma is one of the possibilities.

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Section: Discussionmentioning

confidence: 99%

A Case of Renal Synovial Sarcoma Treated with Adjuvant Ifosfamide and Doxorubicin

Özkan

Mertsoylu²,

Özardalı

2011

Intern. Med.

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“…7 Renal leiomyosarcomas have a very poor prognosis, with most patients dying within 2 years. 8,9 It has been difficult to evaluate the true overall survival rate, as most reports do not have long follow-ups. 4 Because of the poor outcome of renal sarcomas, adjuvant therapy is an attractive choice.…”

Section: Discussionmentioning

confidence: 99%

Renal Leiomyosarcoma Treated With Partial Nephrectomy

Cocuzza¹,

Arap²,

Lucon³

et al. 2005

Clinics

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Primary sarcomas constitute from 0.8% to 2.7% of renal tumors in adults.1,2 Excluding Wilms tumors, 47% to 60% are leiomyosarcomas, 15% liposarcomas, 9% hemangiopericytomas, 7% fibrosarcomas, 6% malignant fibrous histiocytomas, and 5% rhabdomyosarcomas.1,2 The etiology of renal leiomyosarcoma remains obscure.Radical nephrectomy was the treatment of choice used in all but 2 of the cases described, 1,2 in which partial nephrectomy presented good results. 3 CASE REPORTA 52-year-old woman of mixed white and negro blood, suffering from diabetes mellitus, arterial hypertension, and stable angina, was undergoing treatment with enalapril, atenolol, hydrochlorothiazide, metformin, and aspirin. There was no significant familial history of neoplastic diseases. The physical examination was unremarkable. The complete blood count, blood biochemical values, and urinalysis were normal. She underwent magnetic resonance for assessment of the renal vessels, which were normal, though, incidentally, a 2-cm solid lesion was found in the left kidney (Fig. 1). The rest of the abdominal cavity was normal.A partial nephrectomy was undertaken by means of lumbotomy; the surgical specimen revealed a clearly defined solid nodule measuring 1.7 cm, surrounded by normal renal tissue, which did not extend outside Gerota's fascia (Fig. 2).The histopathological examination demonstrated a lowgrade renal leiomyosarcoma with surgical margins that were negative for neoplasia. The immunohistochemical profile showed neoplasia of mesenchymal origin with myofibroblastic muscular differentiation (Fig. 3).

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“…Primary retroperitoneal tumors are reported to account for 0.16% of all malignancies, and 10%-20% of all primary retroperitoneal tumors are liposarcomas [1] . Although liposarcoma is the second most common type of renal sarcoma [2] , renal liposarcoma with inferior vena caval involvement is distinctly rare.…”

Section: Introductionmentioning

confidence: 99%

Liposarcoma arising from the right renal sinus with inferior vena caval involvement

Kobayashi¹,

Nakayama

Matsuzaki

et al. 2015

JST

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A woman aged 55 was introduced to our medical center for retroperitoneal tumor incidentally discovered by screening computerized tomography. Imaging showed a round fatty tumor extending into the right kidney and infiltrating into the inferior vena cava and no distant metastasis. We extirpated the tumor and tumor thrombus infiltrating the inferior vena cava along with the right kidney en bloc. Pathological examination showed well-differentiated liposarcoma that we believe had arisen from the renal sinus. Liposarcoma arising from the renal sinus with intravenous involvement is distinctly rare. Treatment by complete resection is recommended.

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Sarcomas of the Kidney

Abstract: We report a retrospective study of 18 patients with renal sarcomas seen between 1950 and 1980. Renal sarcomas are highly malignant neoplasms and the over-all prognosis is poor, with only 2 long-term survivors in this series. Radical nephrectomy seems to be the treatment of choice.

Cited by 90 publications

References 20 publications

A Case of Renal Synovial Sarcoma Treated with Adjuvant Ifosfamide and Doxorubicin

A Case of Renal Synovial Sarcoma Treated with Adjuvant Ifosfamide and Doxorubicin

Renal Leiomyosarcoma Treated With Partial Nephrectomy

Liposarcoma arising from the right renal sinus with inferior vena caval involvement

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