Sarcomas and malignant phyllodes tumours of the breast – A retrospective study

Confavreux, C; Lurkin, Antoine; Mitton, N.; Blondet, R.; Saba, Corey; Ranchère, Dominique; Sunyach, M.P.; Thiesse, Philippe; Biron, Pierre; Blay, Jean‐Yves; Ray-Coquard, I.

doi:10.1016/j.ejca.2006.05.040

Cited by 112 publications

(130 citation statements)

References 19 publications

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“…Mainstay of treatment is surgery with few subgroups opting for adjuvant radiotherapy [9]. Confavreux et al, divided and compared three groups: (1) phyllodes tumour (2) primary breast sarcoma and malignant phyllodes tumour and (3) angiosarcoma and found the 3-year disease-free survival of, 57, 45 and 7% respectively [14]. In the present case, local recurrence or distant metastasis did not occur even after more than one year post surgery.…”

Section: Discussionmentioning

confidence: 88%

Primary Fibrosarcoma of Male Breast: A Rare Entity

Shukla

Chauhan

Jyotsna

et al. 2014

JCDR

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Primary fibrosarcoma of the breast is a very rare tumor. However, amongst the Primary Breast Sarcoma (PBS), it is the most common subtype. We present a case of 28-year-old male with lump in right breast of 7 year duration. The unilateral multinodular mass showed well circumscribed but unencapsulated tumor composed of interlacing fascicles of spindle shaped cells with minimal atypia. Immunohistochemistry revealed positivity for vimentin in the tumor cells. Differential diagnoses and review of literature is discussed.

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Section: Discussionmentioning

confidence: 88%

Primary Fibrosarcoma of Male Breast: A Rare Entity

Shukla

Chauhan

Jyotsna

et al. 2014

JCDR

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“…[44] However, a majority of the studies indicate advance age (>50 years) as the indicator of LR as well as survival. [30,31,45,46] This could be explained by the fact that the incidence of malignant histology increases with age. [25,47] Whether LR is a predictor for the development of systemic metastasis remains a controversial issue.…”

Section: Histological Classificationmentioning

confidence: 99%

“…Though there was a trend toward improved survival for the group with tumor size 5 cm or less (survival rate 57.7 versus 46.7%), the difference was not statistically significant. [45] Chaney et al reported eight cases of patients who received adjuvant RT at a dose of 60 Gy. [51] Radiotherapy was administered for a combination of reasons, including bulky tumor volume, positive margins, recurrence, and/or malignant histology.…”

Section: Efficacy Of Adjuvant Radiotherapymentioning

confidence: 99%

Phyllodes tumor of the breast: Wolf inside the sheep’s skin!

Wadasadawala¹,

Swain²,

Bajpai³

2016

Oncobiology and Targets

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Phyllodes tumor, previously known as cystosarcoma phyllodes, is a rare fibro-epithelial tumor of breast constituting <1% of all the breast tumors. It is classified into benign, borderline, and malignant subtypes depending upon the histological criteria defined by the World Health Organization and also has an independent prognostic significance. Accurate pretreatment histological diagnosis is important for the optimal management of phyllodes tumor so that low recurrence rates, improved survival, and optimal long-term cosmetic result can be achieved. Despite surgery being the standard of care, the best type of surgery for each histological type is yet to be defined. The higher rate of local recurrence after surgery alone in borderline and malignant phyllodes tumor raises the question regarding the need of adjuvant treatment, especially radiotherapy, which remains underutilized. The perspective of the current review is to provide the state-of-the-art management of phyllodes tumor of the breast and highlight the risk factors associated with recurrence.

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“…In comparison to wide local excision, mastectomy was considered gold standard but recent study conflict this comparison and considered both of them equivocal. 3,5,7,9,13 For smaller localized breast sarcomas most of them recommended wide excision with greater than 3 cm normal tissue margin. 28 But to reduce the risk of local recurrence, mastectomy may be considered for those whose tumors are too large.…”

Section: Surgerymentioning

confidence: 99%

“…[1][2][3]9 Lymph node metastasis is rare. 3,13 The rarity of this pathology led to lack of consensus on the optimal treatment and hence a multidisciplinary approach is needed for diagnosis and treatment of patients. A 45 years old female patient, G 3 P 3 L 3 A 0 in her third year of menopause presented with rapidly growing painless lump in left breast since 5 months.…”

mentioning

confidence: 99%