Sarcoma: Molecular Pathology, Diagnostics, and Therapeutics

Miwa, Shinji; Yamamoto, Norio; Tsuchiya, Hiroyuki

doi:10.3390/ijms24065833

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Sarcoma, originating in mesodermal tissue, presents a rare and heterogeneous group of malignant tumors primarily found in connective, muscle, adipose, nervous, vascular, and lymphatic tissues (Casali et al, 2018;Coindre, 2012). Despite constituting less than 1% of all malignancies, soft tissue sarcomas encompass over 50 subtypes exhibiting diverse biological behaviors (Ferrari et al, 2011;Miwa, Yamamoto, & Tsuchiya, 2023). This diversity poses challenges in accurate diagnosis, limits treatment options, and complicates clinical trials (Grunewald et al, 2020; Sbaraglia, Bellan, & Dei Tos, 2021; Schaefer, Cote, & Hornick, 2018).…”

Section: Introductionmentioning

confidence: 99%

UNC5B Knockdown Enhances Chemotherapy Sensitivity and Immunogenic Cell Death in Sarcoma: A Comprehensive Prognostic Analysis based on PANoptosis and Macrophage

Li,

Du,

Deng

et al. 2024

Preprint

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Purpose Sarcomas represent a heterogeneous collection of malignancies originating from mesodermal tissues, posing significant challenges in diagnosis and treatment. Emerging research has spotlighted PANoptosis—a synergistic process of pyroptosis, apoptosis, and necroptosis—as a novel therapeutic target. This study seeks to construct a prognostic model leveraging PANoptosis and macrophage-related genes to advance the understanding and treatment of sarcoma. Methods Utilizing data from the TCGA-SARC, TARGET-OS cohorts, and GSE159847, we identified genes associated with macrophages and PANoptosis. A prognostic model was formulated through multivariate and LASSO regression analyses, with its efficacy evaluated via Kaplan-Meier survival analysis, ROC curves, and validation with an independent cohort. Comprehensive analyses included functional enrichment, immune microenvironment assessment, and drug response prediction. Additionally, functional assays were performed on 143B cells to elucidate the pivotal gene’s roles. Results The prognostic model, incorporating four genes (CD2, STAT6, TXNIP, UNC5B), effectively categorized samples into high and low risk cohorts with notable survival disparities. Samples from the high-risk group exhibited greater genomic instability and immunosuppressive microenvironments. Functional assays in 143B cells revealed that knockdown of UNC5B reduced cell proliferation and increased sensitivity to paclitaxel, indicating potential therapeutic targets. Conclusion This study highlights the critical role of PANoptosis and macrophage polarization in the sarcoma microenvironment. The prognostic model devised provides a reliable instrument for predicting patient outcomes and tailoring personalized treatment strategies, thereby offering innovative therapeutic pathways for sarcoma management.

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Section: Introductionmentioning

confidence: 99%

UNC5B Knockdown Enhances Chemotherapy Sensitivity and Immunogenic Cell Death in Sarcoma: A Comprehensive Prognostic Analysis based on PANoptosis and Macrophage

Li,

Du,

Deng

et al. 2024

Preprint

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“…A sarcoma could be a cancer that starts inside the body's connective tissues, consolidating cartilage, blood vessels, muscles, bones, and fat [ 2 ]. Sarcomas are perilous tumors that can spread to other body regions and attack enveloping tissues, in contrast to lipomas, which are benign and made of fat cells [ 3 ]. Soft tissue and bone sarcomas are the two basic sarcomas [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Soft tissue and bone sarcomas are the two basic sarcomas [ 4 , 5 ]. Malignant tumors are known as bone sarcomas, which regularly influence the long bones of the arms and legs, and incorporate osteosarcoma (cancer starting in bone-forming cells), Ewing's sarcoma (cancer emerging within the bones or delicate tissue encompassing the bones), and chondrosarcoma (cancer beginning in cartilage cells) [ 1 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…It frequently affects the soft tissues that surround joints as well as the intermuscular planes [ 6 ]. Unbelievably, considering its name, synovial sarcoma is not caused by synovial cells but rather by primitive mesenchymal cells that can develop into spindle cells and epithelial-like components [ 3 , 5 , 6 ]. For synovial sarcoma, wide local excision surgery is a typical treatment strategy [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Synovial Sarcoma in the Right Thigh of a 25-Year-Old Male: A Case Report

Singh,

Gharde,

Shah

et al. 2024

Cureus

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In this article, we describe the diagnosis and surgical treatment of synovial sarcoma within the right thigh of a 25-year-old male. Our article aims to demonstrate successful treatment through wide local excision and rotation flap reconstruction, emphasizing the noteworthiness of comprehensive surgical planning and postoperative care. Postoperative care guaranteed satisfactory healing and appendage functionality, with a follow-up plan to monitor for recurrence. This case underscores the need for individualized treatment approaches and highlights the significance of multidisciplinary care for overseeing aggressive tumors like synovial sarcoma. The findings contribute to the ongoing refinement of surgical procedures and postoperative protocols to improve patient results.

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Management of Liposarcoma With Posterior Intercostal Artery Propeller Flap Reconstruction: A Case Report

Nayak,

Borle,

Aravind Kumar

2024

Cureus

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This case shows the administration of a 57-year-old male with liposarcoma within the right flank region. Surgical treatment of the case included wide local excision (WLE), taken after reconstruction utilizing a posterior intercostal artery propeller flap. Postoperative care included regular checking for signs of repeat. Comparison with similar cases highlights the changeability in clinical introduction and surgical approaches for liposarcomas. This case emphasizes the significance of convenient diagnosis, fastidious surgical procedures, and successful reconstruction in overseeing liposarcomas. This case report points to highlights the clinical administration, surgical intercession, and postoperative care included in treating a giant liposarcoma and compares this case with similar instances to emphasize the challenges and procedures in treating liposarcomas.

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Sarcoma: Molecular Pathology, Diagnostics, and Therapeutics

Abstract: Although the incidence of sarcomas accounts for less than 1% of all malignancies, they are classified into more than 50 different subtypes with different biological behaviours [...]

Cited by 3 publications

References 10 publications

UNC5B Knockdown Enhances Chemotherapy Sensitivity and Immunogenic Cell Death in Sarcoma: A Comprehensive Prognostic Analysis based on PANoptosis and Macrophage

UNC5B Knockdown Enhances Chemotherapy Sensitivity and Immunogenic Cell Death in Sarcoma: A Comprehensive Prognostic Analysis based on PANoptosis and Macrophage

Synovial Sarcoma in the Right Thigh of a 25-Year-Old Male: A Case Report

Management of Liposarcoma With Posterior Intercostal Artery Propeller Flap Reconstruction: A Case Report

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