Sarcoma in irradiated bone. Report of eleven cases

Cahan, William G.; Woodard, Helen Q.; Higinbotham, Norman L.; Stewart, Fred W.; Coley, Bradley L.

doi:10.1002/1097-0142(194805)1:1<3::aid-cncr2820010103>3.0.co;2-7

Cited by 1,136 publications

(417 citation statements)

References 7 publications

Supporting

Mentioning

383

Contrasting

Unclassified

Order By: Relevance

“…The fibrosarcoma of the oesophagus (Case I) developed in soft tissue after 4900 r., which is within the range of 3000 r.-5000 r reported in a number of clinical studies of osteosarcomas, fibrosarcomas, and chondrosarcomas appearing following radiation therapy for benign or malignant conditions (Cahan et al, 1948;Jones, 1953;Sabanas, Dahlin, Childs and Ivins, 20 471 1956). In the young child with fibrosarcoma in the osseous structures of the orbit (Case II), the determination of radiation dose absorbed in bone is concerned with a number of additional factors.…”

Section: Radiation Dosage In Radiotherapysupporting

confidence: 60%

“…3) The induction of spindle cell fibrosarcoma following external irradiation has been frequently described (Cahan, et al, 1948;Cruz, Coley and Stewart, 1957;Jones, 1953); however, few reports are known to the authors of the development of fibrosarcoma following radiation injury to bone in a young child and with a brief latent interval of only 4 years. The criteria for post-irradiation sarcoma established by Cahan et al (1948) were fulfilled, namely (1) roentgenographic evidence of normal bone before irradiation, (2) development of sarcoma in tissue included in the radiotherapeutic beam, (3) a symptom-free latent interval and (4) histological proof of sarcoma in previously normal bone and adjacent tissues. In the cases of irradiation osteosarcoma reviewed by Jones (1953), the latent periods varied from 3 to 22 years with a mean interval of 8-6 years the age of the patients ranged from 9 to 62 years.…”

Section: Case IImentioning

confidence: 99%

“…Data gathered from clinical reports, however, particularly on localised radiation, indicate that doses required for cancer induction may be of a magnitude to produce some form of observable tissue damage (Cade, 1957 ;Cahan, Woodward, Higginbotham, Stewart and Coley, 1948; Glucksmann, Lamerton and Mayneord, 1957). This may not necessarily be associated with the result of architectural or cellular disorientation, since radiotherapeutic experience suggests radiation cancer to be an unusual sequel.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Mechanisms of Radiation Carcinogenesis at the Clinical Level

Fabrikant¹,

Dickson²,

Fetter³

1964

Br J Cancer

View full text Add to dashboard Cite

show abstract

Section: Radiation Dosage In Radiotherapysupporting

confidence: 60%

Section: Case IImentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of Radiation Carcinogenesis at the Clinical Level

Fabrikant¹,

Dickson²,

Fetter³

1964

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…Eligibility for this retrospective study was based on the criteria for RIS published by Cahan et al 20 as modified by Arlen et al 21 : 1) a prior history of RT, 2) the occurrence of sarcoma within the previously irradiated field, 3) histologic confirmation of the sarcomatous nature of the postirradiation lesion, and 4) a latency between irradiation and a second primary sarcoma of at least 3 years. After reviewing the institutional electronic medical records, 53 patients who developed RIS and fulfilled these criteria were included in this study.…”

Section: Methodsmentioning

confidence: 99%

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Liu

Wang

et al. 2010

Cancer

View full text Add to dashboard Cite

BACKGROUND:The increasing incidence of radiation-induced sarcoma (RIS) has become a significant problem that can limit long-term survival. The objective of the current study was to analyze the clinicopathologic characteristics, treatment outcomes, and prognostic factors of RIS after radiotherapy for nasopharyngeal carcinoma (NPC). METH-ODS: Institutional electronic medical records of patients with NPC who received definitive radiotherapy between February 1964 and 2003 were reviewed. Fifty-three patients who developed RIS and fulfilled the study criteria were included. RESULTS: The median follow-up after a diagnosis of RIS was 15.5 months (range, 0.4-90.3 months), and the median latency between radiotherapy for NPC and an RIS diagnosis was 9.3 years (range, 3.2-26.6 years). Fibrosarcoma was the most frequent histologic type observed, followed by osteosarcoma, and malignant fibrous histiocytoma. The 3-year overall survival (OS) rate for 49 patients who received treatment was 32.4%, and the median survival was 21.2 months (95% confidence interval, 8.7-33.8 months). The median OS was 41.3 months, 8.4 months, and 11 months for the complete resection group, the incomplete resection group, and the chemotherapy group, respectively (P<.0001). The only independent predictive factor that was associated with better OS was complete surgical resection. CONCLUSIONS: This retrospective study confirmed the rarity and poor prognosis of RIS in patients with NPC. Complete surgical resection was a significant prognostic factor for survival. The authors concluded that long-term follow-up is necessary for the early detection of RIS in patients with NPC. Cancer 2010;116:5479-86.

show abstract

“…Cahan et al [6] had mentioned four criteria for tumors to be classified as RIS. (1) radiation must have been delivered to the site in question, (2) the new malignancy must arise within the irradiated field, (3) the new tumor must be histologically distinct from the original primary lesion, and (4) a latent period between the time of radiation exposure and development of the new malignancy must be several years.…”

Section: Discussionmentioning

confidence: 99%

Osteosarcoma as a Second Malignant Disease in a Case of Bilateral Retinoblastoma

Agarwal¹,

Kochar²,

Julka

et al. 2011

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Patients with hereditary retinoblastoma, whether treated by radiation or not, are at an increased risk of subsequently developing sarcomas as a second malignancy. As the understanding of the underlying genetics of osteosarcoma and retinoblastoma has improved, a clear association between the two entities has been noted. We present a case of a young patient with previous history of bilateral retinoblastoma who was treated by surgery and chemoradiation for his primary disease and subsequent recurrences. Thirteen years after his initial diagnosis, he developed osteosarcoma of the mandible as the second primary lesion and was treated with surgery and chemotherapy. The intent of the case report is to bring forth the current thinking of genetic association between retinoblastoma and osteosarcoma and to discuss aggressive treatment protocol for the latter, in the form of surgery and chemotherapy.

show abstract

Sarcoma in irradiated bone. Report of eleven cases

Cited by 1,136 publications

References 7 publications

Mechanisms of Radiation Carcinogenesis at the Clinical Level

Mechanisms of Radiation Carcinogenesis at the Clinical Level

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Osteosarcoma as a Second Malignant Disease in a Case of Bilateral Retinoblastoma

Contact Info

Product

Resources

About