Sarcoma botryoides of the uterine cervix in young women: A clinicopathological study of 13 cases

Daya, Dean; Scully, Robert E.

doi:10.1016/0090-8258(88)90228-4

Cited by 146 publications

(139 citation statements)

References 15 publications

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“…Of note, there is a rare association between cervical embryonal rhabdomyosarcoma, ovarian Sertoli-Leydig cell tumour, cystic nephroma, thyroid goitres, pleuropulmonary blastoma and other embryonic neoplasms, and this is secondary to underlying somatic or germline DICER1 mutation. [50][51][52][53][54][55][56][57][58][59] Key practice points: uterine adenosarcoma 1. The diagnosis of adenofibroma should be made sparingly, if at all, as tumours classified as adenofibroma can behave in a similar manner to adenosarcoma.…”

Section: Modern Pathology (2016) 29 S78-s91mentioning

confidence: 99%

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

McCluggage

2016

Modern Pathology

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The current 2014 World Health Organization (WHO) Classification of mixed epithelial and mesenchymal tumours of the uterus includes categories of carcinosarcoma, adenosarcoma, adenofibroma, adenomyoma and atypical polypoid adenomyoma, the last two lesions being composed of an admixture of benign epithelial and mesenchymal elements with a prominent smooth muscle component. In this review, each of these categories of uterine neoplasm is covered with an emphasis on practical tips for the surgical pathologist and new developments. In particular, helpful clues in the distinction between carcinosarcoma and dedifferentiated endometrial carcinoma will be discussed. In addition, salient features to help distinguish between adenofibroma, adenosarcoma, embryonal rhabdomyosarcoma and other mesenchymal neoplasms in the differential diagnosis will be outlined. Finally, a discussion of adenomyoma and its main differential diagnostic considerations will be covered.

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Section: Modern Pathology (2016) 29 S78-s91mentioning

confidence: 99%

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

McCluggage

2016

Modern Pathology

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“…Daya et al reported a series of these patients with conservative approach and favorable outcome (10).…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyosarcoma of the Cervix, Local Excision or Radical Surgery (Report of Two Cases and Review of the Literature)

Akhavan¹,

Tehranian²,

Abadi³

2016

J Obstet Gynecol Cancer Res

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Introduction: Embryonal (Botryoid) Rhabdomyosarcoma (RMS) is an aggressive malignancy that arises from embryonal rhabdomyoblasts. It is commonly seen in the genital tract of female infants and young children. The primary site of these tumors is closely related to the age of the patient. Embryonal Rhabdomyosarcoma has a marked tendency for local recurrence after excision. Due to young age of affected patients who desire fertility, the management of this rapidly growing malignancy is very critical and poses challenges. Case Presentation: We report on two cases embryonal rhabdomyosarcoma of uterine cervix, who were referred to Imam Khomeini hospital during year 2014. Both of them were young virgin females. The presenting symptom for both was vaginal bleeding and protrusion of polypoid mass from the hymen. After neoadjuvant chemotherapy, radical hysterectomy was offered to them. One of them refused, thus local excision was done. Both patients received adjuvant chemotherapy yet in the patient with local excision, the tumor recurred with multiple metastases. Conclusions: There are several methods of surgical approach and variation in adjuvant therapy in the management of embryonal rhabdomyosarcoma. If we choose a conservative approach for surgery of early stage, surgical margin should be negative and in other cases doing radical surgery is the best.

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“…The gross examination reveals the polypoidal growth with a grapes like appearance with smooth, glistening surface and areas of hemorrhages [6].. Microscopic examination shows polypoidal lesion lined by stratified squamous epithelium.…”

Section: Discussionmentioning

confidence: 99%

Botryoid rhabdomyosarcoma of cervix - A Rare case report

Rao¹

2017

NMJ

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Sarcoma botryoides of the uterine cervix in young women: A clinicopathological study of 13 cases

Cited by 146 publications

References 15 publications

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

Rhabdomyosarcoma of the Cervix, Local Excision or Radical Surgery (Report of Two Cases and Review of the Literature)

Botryoid rhabdomyosarcoma of cervix - A Rare case report

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