Sarcoma and metastatic carcinoma

Wolf, Robert

doi:10.1002/(sici)1096-9098(200001)73:1<39::aid-jso11>3.0.co;2-q

Cited by 9 publications

(9 citation statements)

References 48 publications

(45 reference statements)

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“…Surgical resection was complete when the tumor was resected with bone and soft tissue margins that were free of tumor, as shown by histologic analysis, and was incomplete if the tumor was unresectable or was resected with bone or soft tissue margins that were positive for tumor, also as shown by histologic analysis. External hemipelvectomy was defined as surgical resection of pelvic tumors with amputation of the distal limb, and internal hemipelvectomy was defined as surgical resection of pelvic tumors with preservation of the distal limb 10. Assessment of histologic response of the tumor to preoperative chemotherapy used the four‐grade system described by Huvos and colleagues 11, 12.…”

Section: Methodsmentioning

confidence: 99%

Characterization of new multimeric erythropoietin receptor agonists

2008

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In addition to its natural ligand, the receptor for erythropoietin can be activated by small peptides known as erythropoietin mimetic peptides (EMPs). Although EMPs are less potent than the natural ligand, EMP dimers, consisting of two EMPs joined via a linker, have been shown to exhibit significantly improved activity compared to the corresponding monomers, with potency approaching that of the native hormone. In this study, we used a panel of novel EMP dimers to explore the effects of linker length and EMP attachment site on potency. The EC50 values obtained in an EPO-dependent proliferation assay indicated that, as has been shown with similar molecules, EMP dimerization can lead to increases in potency of more than 2 orders of magnitude. We found that both C-terminal and N-terminal attachment of the linker to EMP was tolerated, and that, with the exception of the shortest linker, all of the linker lengths tested provided a similar increase in potency. In follow-up work devised to explore the potential benefit of contacting additional cell surface EPO receptors, we designed a tetrameric template consisting of lysine-based dimers joined via commercial PEG linkers of various molecular weights. Evaluation of the resulting molecules indicated a clear effect of PEG linker size on activity, while the "dimer of dimer" with the shortest linker exhibited 10-fold lower potency than the corresponding dimer, the longest tetramer increased potency by fivefold. We discuss the implications of these results for the further development of EMP multimers.

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Section: Methodsmentioning

confidence: 99%

Characterization of new multimeric erythropoietin receptor agonists

2008

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“…There are several grading systems for osteosarcoma. The Musculoskeletal Tumor Society staging system [10,11] for osteosarcoma is based on tumor grade (I = low-grade; II = high-grade), tumor extension (A = intra-compartmental; B = extra-compartmental), and presence of macroscopic distant metastases (III). Localized high-grade osteosarcoma is classified as stage IIA or IIB.…”

Section: Osteosarcomamentioning

confidence: 99%

“…CT is often used to improve assessment, as it can delineate tumors in inaccessible sites. The 3-dimensional anatomy of the pelvis is difficult to interpret with conventional radiology; CT is particularly helpful in such situations [10]. CT can reveal the extent of both intra- and extra-osseous spread, as well as metastasis [18].…”

Section: Osteosarcomamentioning

confidence: 99%

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Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing’s sarcoma

Dai

et al. 2011

Med Sci Monit

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SummaryThe most prevalent forms of bone cancer are osteosarcoma, chondrosarcoma, and Ewing’s sarcoma. Although chemotherapy and radiotherapy have replaced traditional surgical treatments, survival rates have undergone only marginal improvements. Current knowledge of the molecular pathways involved in each type of cancer has led to better approaches in cancer treatment. A number of cell signaling molecules are involved in tumorigenesis, and specific targets have been identified based on these signal transducers. This review highlights some of the important cellular pathways and potential therapeutic targets, tumor site-specific irradiation techniques, and novel drug delivery systems used to administer these drugs.

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“…Unfortunately, the aforementioned procedures have a significant risk of negatively influencing functional outcome (4, 5). Furthermore, there is a high rate of complications, such as recurrence (ranging from 21 to 38%) and infection (ranging from 20 to 47%), which seems inherent with the magnitude of the surgery (6–10).…”

Section: Introductionmentioning

confidence: 99%

Microwave Ablation of Primary Malignant Pelvic Bone Tumors

et al. 2019

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Background: En bloc tumor resection followed by reconstruction is a widely used surgical treatment for malignant pelvic bone tumors. High rates of complications and mechanical instability often contribute to poor postoperative results. We attempted en bloc microwave ablation (MWA) in situ to improve the outcome.Methods: From May 1995 to December 2015, 104 patients with primary pelvic malignancy received radical MWA in our department. After careful dissection of the tumor-bearing bone from surrounding normal tissues with safe margins, a microwave antenna array was inserted into the tumor mass to emit electromagnetic energy, inducing tumor cellular death via thermocoagulation. The loose, devitalized tumor tissues were removed by cutting or curettage, leaving a defective bone scaffold. Re-strengthening by autograft or allograft was needed in most patients.Results: The over 3 years survival rate was 51.5% for high-grade malignancies (among them, 26.9% were osteosarcoma) and 94.8% for low-grade malignancies (chondrosarcoma). In most of the living patients, cosmetic and useful limbs were preserved. The mean functional score (Musculoskeletal Tumor Society) was 27 or 90% (range: 25–30, 75–100%). Among the 56 patients who belonged to the excellent function group, 11 were followed up for more than 10 years. The local recurrence rate was 8.6%. Among the 9 patients with recurrence, 5 died from disease, 2 were treated by hemipelvic amputation, and 2 underwent revision surgery with MWA and gained local control. The deep infection rate was 5.6%. All six patients with infection were healed by irrigation, debridement, and systemic antibiotic administration.Conclusion: Local, microwave-induced hyperthermia for treating malignant pelvic bone tumors is an effective alternative method. The oncological and functional results are encouraging. The use of MWA should be continued to evaluate and improve this new therapeutic system.

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Sarcoma and metastatic carcinoma

Cited by 9 publications

References 48 publications

Characterization of new multimeric erythropoietin receptor agonists

Characterization of new multimeric erythropoietin receptor agonists

Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing’s sarcoma

Microwave Ablation of Primary Malignant Pelvic Bone Tumors

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