Sarcoidosis with renal involvement

Abstract

Summary Nine of ninety patients with sarcoidosis were found to have significant renal impairment. Epithelioid granulomata were present in five of eight patients who had renal biopsies and glomerular lesions were present in six. There was close correlation between hypercalcaemia, hyperuricaemia, nephrocalcinosis and creatinine clearance. In one patient, renal sarcoidosis complicated membrano-proliferative glomerulonephritis and one patient died in end-stage renal disease.

Membranoproliferative Glomerulonephritis Associated with Pulmonary Sarcoidosis

“…Membranous and pro liferative glomerulonephritis with deposits of IgG and C3 most prominent in mesangial areas, are the most fre quently encountered types of glomerulonephritis. To our knowledge, only 5 cases of membranoproiiferative glo merulonephritis during sarcoidosis have been reported previously [5][6][7]. Immunofluorescence studies in 2 pa tients revealed the presence of diffuse granular and linear deposits of C3, IgG and IgA or IgM.…”

Granulomatous interstitial nephritis causing renal failure, a rare presentation of childhood sarcoidosis

“…4 Kidney involvement is reported in 10% patients. 5 Significant renal involvement leading to renal failure is uncommon 6 . It is very rare to have a young child presenting with advanced renal failure secondary to renal sarcoid without any lung involvement and hence this case is being reported.…”

Renal Involvement in Sarcoidosis

“…Extensive biopsy and post-mortem studies have shown that granulomatous renal involvement is present in only 4 to 20 percent of all patients with sarcoidosis. Primary glomerular disease has been observed with much less frequency, despite the increasing number of reports (3)(4)(5)(6)(7)(8). Renal involvement in sarcoidosis can be divided into three groups as follows: nephropathy due to aberrant calcium metabolism, sarcoid interstitial nephritis and sarcoid glomerulopathy (7,9).…”