Sarcoidosis presenting with severe hypocalcaemia

Saeed, Aamir; Khan, Maria Usman; Irwin, S. T.; Fraser, Alexander

doi:10.1007/s11845-009-0277-9

Cited by 10 publications

(5 citation statements)

References 6 publications

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“…19 In addition, the most recent large population-based studies have not confirmed an increased incidence of lymphoma in patients with sarcoidosis. 20 Finally, clinically it is not likely that this patient has sarcoidosis, given that there have been only several reports of sarcoidosis or possible sarcoidosis in patients with DiGeorge syndrome (1 with mediastinal adenopathy, 21 1 with “sarcoid dermatitis” after isoniazid therapy with a negative “sarcoidosis workup,” 22 and 1 “suggestive of ocular sarcoidosis” 23 ).…”

Section: Discussionmentioning

confidence: 94%

Pulmonary Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Associated with Granulomatous Inflammation in a Child with Chromosome 22q11.2 Deletion Syndrome (DiGeorge Syndrome)

Pongpruttipan¹,

Cook²,

Reyes‐Múgica³

et al. 2012

The Journal of Pediatrics

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Section: Discussionmentioning

confidence: 94%

Pulmonary Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Associated with Granulomatous Inflammation in a Child with Chromosome 22q11.2 Deletion Syndrome (DiGeorge Syndrome)

Pongpruttipan¹,

Cook²,

Reyes‐Múgica³

et al. 2012

The Journal of Pediatrics

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“…Destruction of the parathyroid glands secondary to granulomatous infiltration (e.g. sarcoidosis, amyloidosis, Riedel’s thyroiditis) has been reported (30, 31, 32, 33, 34).…”

Section: Nonsurgical Causes Of Hypoparathyroidismmentioning

confidence: 99%

Standards of care for hypoparathyroidism in adults: a Canadian and International Consensus

Khan

Koch

Uum

et al. 2019

European Journal of Endocrinology

102

158

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Purpose: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults. Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords ‘hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy’. Only English language papers involving humans were included. We excluded letters, reviews and editorials. The quality of evidence was evaluated based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. These standards of care for hypoparathyroidism have been endorsed by the Canadian Society of Endocrinology and Metabolism. Results: Hypoparathyroidism is a rare disease characterized by hypocalcemia, hyperphosphatemia and a low or inappropriately normal serum parathyroid hormone level (PTH). The majority of cases are post-surgical (75%) with nonsurgical causes accounting for the remaining 25% of cases. A careful review is required to determine the etiology of the hypoparathyroidism in individuals with nonsurgical disease. Hypoparathyroidism is associated with significant morbidity and poor quality of life. Treatment requires close monitoring as well as patient education. Conventional therapy with calcium supplements and active vitamin D analogs is effective in improving serum calcium as well as in controlling the symptoms of hypocalcemia. PTH replacement is of value in lowering the doses of calcium and active vitamin D analogs required and may be of value in lowering long-term complications of hypoparathyroidism. This manuscript addresses acute and chronic management of hypoparathyroidism in adults. Main conclusions: Hypoparathyroidism requires careful evaluation and pharmacologic intervention in order to improve serum calcium and control the symptoms of hypocalcemia. Frequent laboratory monitoring of the biochemical profile and patient education is essential to achieving optimal control of serum calcium.

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“…В редких случаях причиной гипопаратиреоза могут стать инфильтративные заболевания, такие как саркоидоз, амилоидоз, тиреоидит Риделя и метастатическое поражение ОЩЖ [12][13][14][15]. Ткань ОЩЖ относительно не восприимчива к лучевому повреждению, тем не менее в литературе описаны очень редкие случаи радиационно-индуцированного гипопаратиреоза [16][17][18][19].…”

Section: этиологияunclassified

Review of clinical practice guidelines for hypoparathyroidism

Ковалева

Eremkina

Krupinova

et al. 2021

Probl Endokrinol (Mosk)

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Hypoparathyroidism is a rare disorder characterized by the absent or inappropriately decreased serum parathyroid hormone in the parathyroid glands, which is accompanied by impaired calcium-phosphorus metabolism.The main etiology of hypoparathyroidism remains damage or removal of the parathyroid glands during neck surgery. In view of the incidence of thyroid cancer, primary hyperparathyroidism and other pathologies of the neck organs, which radical treatment can lead to the parathyroid gland impairment, an increased number of patients with hypoparathyroidism is expected. Autoimmune hypoparathyroidism is the second most common form of the disease, usually occurring as part of type 1 autoimmune polyglandular syndrome. Autoimmune hypoparathyroidism usually occurs in childhood and is characterized by a severe course of the disease, especially in the case of concomitant malabsorption syndrome.Chronic hypoparathyroidism of any etiology requires lifelong multicomponent therapy, as well as careful monitoring and an individual approach to choose the optimal treatment strategy. In the absence of adequate follow-up, the risks of long-term complications significantly increase, particularly in the renal, cardiovascular systems; in the soft tissues and in the brain, it could lead to visual disturbances; pathology of the musculoskeletal system with a decreased bone remodeling and a potential risk of fractures, as well as to the neurocognitive disorders and an impaired health-related quality of life.Timely diagnosis, rational medical therapy and management strategy may reduce the risks of short-term and long-term complications, frequency of hospitalizations and disability of patients, as well as improve the prognosis.This review covers the main issues of Russian guidelines for the management of chronic hypoparathyroidism, approved in 2021, including laboratory and instrumental evaluation, treatment approaches and follow-up. This guidelines also include the recommendations for special groups of patients: with acute hypocalcemia, hypoparathyroidism during pregnancy.

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Sarcoidosis presenting with severe hypocalcaemia

Cited by 10 publications

References 6 publications

Pulmonary Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Associated with Granulomatous Inflammation in a Child with Chromosome 22q11.2 Deletion Syndrome (DiGeorge Syndrome)

Pulmonary Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Associated with Granulomatous Inflammation in a Child with Chromosome 22q11.2 Deletion Syndrome (DiGeorge Syndrome)

Standards of care for hypoparathyroidism in adults: a Canadian and International Consensus

Review of clinical practice guidelines for hypoparathyroidism

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