Sarcoidosis of the Nose and Paranasal Sinuses

Trachtenberg, Stanford B.; Wilkinson, Evelyn E.; Jacobson, George

doi:10.1148/113.3.619

Cited by 11 publications

(4 citation statements)

References 18 publications

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“…83,110,115 Involvement of facial bones is often associated with prominent granulomatous lesions of the paranasal sinuses, nasal skin and mucosa, or lacrimal glands. 83,102,117 Facial involvement may mimic neoplasm, Wegener's granulomatosis, leprosy, mycosis, syphilis, or other granulomatous infectious causes. 83 Isolated cases of clubbing have been described, with 118 or without 119 hypertrophic osteoarthropathy.…”

Section: Epidemiology and Prevalence Of Osseous Sarcoidmentioning

confidence: 99%

“…The presence of facial bone sarcoidosis is strongly linked to the presence of lupus pernio. 113,117,124,125 Moreover, granulomatous involvement of the paranasal sinuses can result in facial bone destruction. 117 Skull involvement is unusual but is almost universally associated with bone lesions elsewhere.…”

Section: Radiographic Featuresmentioning

confidence: 99%

“…113,117,124,125 Moreover, granulomatous involvement of the paranasal sinuses can result in facial bone destruction. 117 Skull involvement is unusual but is almost universally associated with bone lesions elsewhere. 112 In cases of multifocal lytic lesions, sarcoidosis of the calvarium may be confused with malignancy.…”

Section: Radiographic Featuresmentioning

confidence: 99%

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Sarcoidosis Involving the Musculoskeletal System

Zisman¹,

Shorr²,

Lynch³

2002

Seminars in Respiratory and Critical Care Medicine

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Although sarcoidosis can affect virtually any organ, musculoskeletal involvement is infrequent. Early in the course of the disease, acute polyarthritis may be observed in up to 40% of patients, but this is often self-limited. Chronic or recurrent sarcoid arthritis is rare, affecting only 1 to 4% of patients. Asymptomatic involvement of muscles has been reported in 25 to 75% of patients in small series, but symptomatic involvement of muscles is rare. Although prospective studies assessing the prevalence of muscle involvement in sarcoidosis have not been done, several large retrospective studies suggest that symptomatic muscle involvement occurs in < 0.5% of patients with sarcoidosis. Patterns of sarcoid muscle involvement include chronic, progressive myopathy; nodular or tumorous sarcoidosis affecting muscles; and an acute polymyositis-like syndrome. Corticosteroid therapy is usually efficacious for the acute myositis variant but is less consistently helpful in the other forms (e.g., chronic myopathy or nodules). Similarly, clinically significant involvement of bone is rare (< 2-5%), and is often associated with chronic multisystemic disease, lupus pernio, and chronic uveitis. Unfortunately, osseous sarcoidosis is often unresponsive to therapy. In this review, we discuss the prevalence, clinical features, and management of sarcoidosis involving muscle, joints, and bones.

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Section: Epidemiology and Prevalence Of Osseous Sarcoidmentioning

confidence: 99%

Section: Radiographic Featuresmentioning

confidence: 99%

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Sarcoidosis Involving the Musculoskeletal System

Zisman¹,

Shorr²,

Lynch³

2002

Seminars in Respiratory and Critical Care Medicine

View full text Add to dashboard Cite

show abstract

“…136,137,139,140 In lymphomas, lymph node enlargement is more pronounced and retrocrural regions are more frequently affected. 137,139 Other Organs CT scans may be useful to assess site and extent of disease for sarcoidosis involving the orbits 141,142 sinuses, 143 or nasopharynx. 11,143 In addition, chest CT may detect enlarged mediastinal or hilar nodes in patients with uveitis and normal chest radiographs; in this context, a diagnosis of sarcoidosis can be substantiated by mediastinoscopic lymph node biopsy 144 or fiberoptic bronchoscopy with transbronchial lung biopsies.…”

Section: Extrapulmonary Involvement (Selected Sites)mentioning

confidence: 99%

Computed Tomographic Scanning in Sarcoidosis

Lynch

2003

Seminars in Respiratory and Critical Care Medicine

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Sarcoidosis is a granulomatous disease of unknown etiology that involves the lungs or intrathoracic lymph nodes in more than 90% of patients. The clinical spectrum of sarcoidosis is protean, but pulmonary manifestations often dominate. Chest radiographs are abnormal in 90 to 95% of patients with sarcoidosis; the most characteristic feature is bilateral hilar lymphadenopathy (BHL), present in 50 to 80% of patients. Pulmonary parenchymal infiltrates are present in 25 to 50% of patients. In this article, we review the radiographic features of sarcoidosis (both typical and atypical), and the impact of chest radiographic stage on long-term prognosis. Computed tomographic (CT) scans are more sensitive than chest radiographs in delineating parenchymal, mediastinal, and hilar structures, and distinctive CT patterns may be virtually pathognomonic for sarcoidosis in some patients. Routine CT scan is not appropriate to diagnose or manage sarcoidosis, but CT may be invaluable in patients with atypical clinical or chest radiographic findings or specific complications of sarcoidosis (pulmonary or extrapulmonary), or to assess prognosis. High-resolution thin-section CT scans (HRCT) may be helpful in selected patients with stage II or III sarcoidosis to discriminate active inflammation from irreversible fibrosis. This article discusses the salient HRCT features of sarcoidosis, accuracy of CT in the differential diagnosis, and correlations of HRCT with disease extent and activity, pulmonary function, and lesion reversibility.

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Systemische Osteoarthropathien

Rand¹

Handbuch Diagnostische Radiologie

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Sarcoidosis of the Nose and Paranasal Sinuses

Cited by 11 publications

References 18 publications

Sarcoidosis Involving the Musculoskeletal System

Sarcoidosis Involving the Musculoskeletal System

Computed Tomographic Scanning in Sarcoidosis

Systemische Osteoarthropathien

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