Sarcoidosis of the Breasts following Silicone Implant Placement

Sun, Hank H.; Sachanandani, Neil S.; Jordan, Brenda; Myckatyn, Terence M.

doi:10.1097/prs.0b013e31828bd964

Cited by 18 publications

(22 citation statements)

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“…However, the presence of foreign bodies in granulomatous skin lesions of patients with sarcoidosis is not a rare event and may contribute to this incidence 3 . Silicone has been proposed to induce formation of sarcoidal granulomas via a macrophage-mediated foreign body reaction, in which silicone serves as an immunologic adjuvant to enhance the antigen-specific immune response 4 . This phenomenon is known as autoimmune/inflammatory syndrome induced by adjuvants, abbreviated as ASIA 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Silicone has been proposed to induce formation of sarcoidal granulomas via a macrophage-mediated foreign body reaction, in which silicone serves as an immunologic adjuvant to enhance the antigen-specific immune response 4 . This phenomenon is known as autoimmune/inflammatory syndrome induced by adjuvants, abbreviated as ASIA 4 . Gluteal sarcoid lesions occurring after cosmetic silicone injections are rare.…”

Section: Discussionmentioning

confidence: 99%

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A woman with firm plaques on the buttocks and thighs

2019

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A woman with firm plaques on the buttocks and thighs

2019

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“…Foreign-body reactions can also result in granulomatous lesions following silicone implant rupture or leakage and must be distinguished from "true" sarcoidosis, which occurs in the absence of breast implant rupture [128].…”

Section: Sarcoidosismentioning

confidence: 99%

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Goulabchand

Hafidi

Perre

et al. 2020

JCM

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Mastitis frequently affects women of childbearing age. Of all the pathological breast conditions requiring specific management, autoimmune mastitis is in the third position after infection and breast cancer. The aim of this literature review was to make a comprehensive description of autoimmune diseases targeting the mammary gland. Four main histological patterns of autoimmune mastitis are described: (i) lymphocytic infiltrates; (ii) ductal ectasia; (iii) granulomatous mastitis; and (iv) vasculitis. Our literature search found that all types of autoimmune disease may target the mammary gland: organ-specific diseases (diabetes, thyroiditis); connective tissue diseases (such as systemic erythematosus lupus or Sjögren’s syndrome); vasculitides (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, giant cell arteritis, polyarteritis nodosa, Behçet’s disease); granulomatous diseases (sarcoidosis, Crohn’s disease); and IgG4-related disease. Cases of breast-specific autoimmune diseases have also been reported, including idiopathic granulomatous mastitis. These breast-limited inflammatory diseases are sometimes the first symptom of a systemic autoimmune disease. Although autoimmune mastitis is rare, it is probably underdiagnosed or misdiagnosed. Early diagnosis may allow us to detect systemic diseases at an earlier stage, which could help to initiate a prompt, appropriate therapeutic strategy. In case of suspected autoimmune mastitis, we hereby propose a diagnostic pathway and discuss the potential pathophysiological pathways leading to autoimmune breast damage.

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“…40 Silicone as an adjuvant potentiates the immune response by promoting adaptive immune cell proliferation and cytokine release that leads to T cell proliferation and polarization. 41 Additionally, silicone is notable for enhancing immnoreactivity by its reaction with components of the connective tissue including mucopolysaccardies and naturally occurring silicone substances. 42 As with previously mentioned diseases, exposure to silicone adjuvants led to immunologically-mediated immune responses that manifested as arthralgia, arthritis, malaise and pyrexia, headaches, fatigue and generalized weakness.…”

Section: Silicone and Asia Syndromementioning

confidence: 99%

The ASIA syndrome: basic concepts

Watad¹,

Sharif²,

Shoenfeld³

2017

MJR

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The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld's syndrome, encompasses several autoimmune conditions/phenomena that are induced following the exposure to substances with adjuvant activity. The disease spectrum is heterogeneous in respect to clinical presentation as well as severity of the clinical manifestations. Adjuvants are included in vaccination formulations for their immunogenic properties. Despite being generally well tolerated, safe and effective, some genetically predisposed individuals can develop generalized non-specific constitutional symptoms, autoantibody production, new onset, or worsening of disease presentation. In this review, we focus on the current knowledge presented in the literature on ASIA syndrome, increasing physician awareness about the basic concepts of ASIA syndrome and highlight the devastating amount of data accumulated in the last few years concerning the relationship between various adjuvants and autoimmunity.

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Sarcoidosis of the Breasts following Silicone Implant Placement

Cited by 18 publications

References 1 publication

A woman with firm plaques on the buttocks and thighs

A woman with firm plaques on the buttocks and thighs

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

The ASIA syndrome: basic concepts

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