Sarcoidosis expressing as four distinct cutaneous lesions

Maejima, Hideki; Nakahara, Chihoko; Watarai, Akira; Katsuoka, Kensei

doi:10.1684/ejd.2010.0949

Cited by 4 publications

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“…Like sarcoidosis, vasculitis can represent relatively benign, single‐organ (cutaneous) disease, or a systemic, multiorgan disease with poor prognosis . Sarcoidal granulomas associated with cutaneous vasculitis are a rare event, but they have been documented in the setting of granulomatous vasculitis (GV) and leukocytoclastic vasculitis (LCV) …”

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Circumscribed cicatricial alopecia due to localized sarcoidal granulomas and single‐organ granulomatous arteritis: a case report and systematic review of sarcoidal vasculitis

et al. 2015

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Vasculitis associated with sarcoid granulomas is an uncommon phenomenon. A 72-year-old female presented with an expanding region of circumscribed alopecia and scalp atrophy of 2 months duration. Biopsy showed non-caseating granulomas, dermal thinning, loss of follicles, fibrosis and muscular vessels disrupted by mixed lymphocyte, macrophage and giant-cell infiltrates. Affected vessels had loss and fragmentation of the elastic lamina, fibrous replacement of their walls and luminal stenosis (endarteritis obliterans). Dermal and vascular advential intralymphatic granulomas and lymphangiectases were found by D2-40 expression, suggesting lymphatic obstruction and poor antigen clearance. No evidence of a post-zoster eruption, systemic sarcoidosis or systemic giant-cell arteritis was found. Two years later, prednisone had halted - but not reversed - progression of her alopecia. Review of the literature showed two types of vasculitis associated with sarcoid granulomas: (i) acute, self-limited leukocytoclastic vasculitis and (ii) chronic granulomatous vasculitis (GV). Persistence of non-degradable material or antigen contributes to the pathogenesis of granulomatous inflammation. In this case, lymphatic obstruction probably impeded clearance of nonimmunologic and/or immunologic stimuli permitting and sustaining the development of sarcoid granulomas and sarcoid GV, ultimately causing scarring alopecia and cutaneous atrophy.

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Circumscribed cicatricial alopecia due to localized sarcoidal granulomas and single‐organ granulomatous arteritis: a case report and systematic review of sarcoidal vasculitis

et al. 2015

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Sarcoidosis

Marcoval,

Mañá

2016

Rook's Textbook of Dermatology, Ninth Edition

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Sarcoidosis is an antigen‐mediated disease of unknown aetiology characterized by the presence of non‐caseating epithelioid cell granulomas in multiple organs. It involves mainly the lungs, mediastinal and peripheral lymph nodes, eyes and skin. Less frequent but usually severe manifestations can occur in the liver, spleen, central nervous system, heart, upper respiratory tract and bones. Cutaneous lesions of sarcoidosis may be specific, showing histopathologically sarcoid granulomas, or non‐specific, mainly erythema nodosum. Cutaneous lesions are frequently the presentation of the disease and skin biopsy enables early diagnosis. Moreover, some types of lesions have prognostic significance and may help to predict the outcome of the systemic disease.

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Sarcoidosis

Marcoval,

Mañá

2024

Rook's Textbook of Dermatology

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Sarcoidosis is an antigen‐mediated disease of unknown aetiology characterised by the presence of non‐caseating epithelioid cell granulomas in multiple organs. It involves mainly the lungs, mediastinal and peripheral lymph nodes, eyes and skin. Less frequent but usually severe manifestations can occur in the liver, spleen, central nervous system, heart, upper respiratory tract and bones. Cutaneous lesions of sarcoidosis may be specific, showing histopathologically sarcoid granulomas, or non‐specific, mainly erythema nodosum. Cutaneous lesions are frequently the presentation of the disease and skin biopsy enables early diagnosis. Moreover, some types of lesions have prognostic significance and may help to predict the outcome of the systemic disease.

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Sarcoidosis expressing as four distinct cutaneous lesions

Cited by 4 publications

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Circumscribed cicatricial alopecia due to localized sarcoidal granulomas and single‐organ granulomatous arteritis: a case report and systematic review of sarcoidal vasculitis

Circumscribed cicatricial alopecia due to localized sarcoidal granulomas and single‐organ granulomatous arteritis: a case report and systematic review of sarcoidal vasculitis

Sarcoidosis

Sarcoidosis

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