Sarcoidosis

Dempsey, Owen; Paterson, E. W; Kerr, Keith M.; Denison, Alan

doi:10.1136/bmj.b3206

Cited by 93 publications

(99 citation statements)

References 7 publications

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“…1,2 The spectrum of clinical symptoms of sarcoidosis is wide and related to the possible location of the lesions. 3 The clinical course and prognosis of the diseases is variable; acute forms including Lö fgren's syndrome (LS) resolve spontaneously in most cases. On the other hand, chronic pulmonary sarcoidosis may progress to the lung fibrosis and result eventually in respiratory failure.…”

Section: Introductionmentioning

confidence: 99%

Functional variant ANXA11 R230C: true marker of protection and candidate disease modifier in sarcoidosis

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Functional variant ANXA11 R230C: true marker of protection and candidate disease modifier in sarcoidosis

et al. 2011

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“…Frequently observed, specific clinical features are shortness of breath, cough, and chest pain (pulmonary) 1 ; cranial nerve palsy (neurological); and erythema nodosum, maculopapular lesion, or lupus pernio (dermatological). [1][2][3] Nonspecific symptoms are chronic fatigue, weight loss, night sweats, fever, and malaise. [3][4][5] Fatigue is one of the most common symptoms in sarcoidosis, 6 and it impairs quality of life.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated With Fatigue in Sarcoidosis

Fleischer¹,

Hinz²,

Brähler³

et al. 2013

Respir Care

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BACKGROUND: Fatigue is a frequent symptom of patients with sarcoidosis. The origin of fatigue associated with sarcoidosis is unclear. The aim of this study was to assess the impact of affected organs, medication, and comorbidity on fatigue related to sarcoidosis. METHOD: In collaboration with the German Sarcoidosis Society, a sample of 1,197 subjects diagnosed with sarcoidosis was examined. The participants completed a questionnaire that contained the Fatigue Assessment Scale and the Multidimensional Fatigue Inventory. RESULTS: In this study, muscles, bones, and nerves were most strongly associated with fatigue. Patients receiving prednisolone showed heightened fatigue levels. However, the association between the duration of prednisolone therapy and fatigue was weak. The concomitant diseases, pulmonary hypertension and sleep apnea, showed the greatest impact elevating fatigue (effect sizes d > 0.50). In the combined regression analysis, comorbidity was the most important predictor of fatigue. CONCLUSIONS: It is important to consider that multiple clinical factors, especially comorbidities, contribute to the high degrees of fatigue in sarcoidosis.

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“…dIsCussIon Sarcoidosis is a multisystem granulomatous disease which can affect any organ. 2,3 In a general practice with 10 000 patients, one to two patients will develop sarcoidosis each year, although this will vary with practice population as the disease is more common in certain racial groups, such as AfricanAmericans. It predominantly affects young and middle-aged people.…”

Section: Case Reportmentioning

confidence: 99%

“…The cause is not known, but it may occur in genetically susceptible people exposed to unknown environmental triggers. 2 Histologically the disease is characterised by the formation of granulomas which may resolve spontaneously, but in 20-25% of patients will result in pulmonary fibrosis.…”

Section: Case Reportmentioning

confidence: 99%