Sarcoïdose et réaction sarcoïdosique associées à la maladie de Hodgkin

Salvage treatment in patients with recurrent Hodgkin's disease is more effective when tumor burden is minimal. That is why more intensive follow‐up strategies, including frequent imaging tests, have been recently developed for the detection of early relapse. However, as screening procedures become more sensitive, there is an increasing risk of false‐positive results, demonstrating nonmalignant proliferative disorders. We describe three young patients who had lymphocyte‐predominant or mixed‐cellularity Hodgkin's disease and were in clinical complete remission for 2.5–3 years after a combined treatment with chemotherapy and radiation. Imaging tests revealed new gallium‐avid lymphadenopathy in the chest in two cases. Pathologically enlarged pelvic lymph nodes were identified in another case, after a diagnosis of recurrent disease in axilla. Those findings were interpreted as relapse, and the patients underwent thoracotomy and laparotomy, respectively, for histologic confirmation. The results showed progressively transformed germinal centers and sarcoid‐like lesions, two benign proliferative disorders. When patients with Hodgkin's disease in remission show new lymphadenopathy, even with positive gallium scan, it seems mandatory to obtain tissue for histologic examination, even through invasive procedures such as laparotomy and thoracotomy, to avoid wrong diagnosis and unnecessary treatment. Med. Pediatr. Oncol. 28:187–190 © 1997 Wiley‐Liss, Inc.

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Benign proliferative lesions mimicking recurrence of Hodgkin's disease

Epelbaum

Ben-Arie

Bar‐Shalom

et al. 1997

Med. Pediatr. Oncol.

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Hodgkin's lymphoma initially presenting with polymyalgic symptoms: a case report

et al. 2007

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The association of polymyalgic symptoms and lymphoma is a rare event whose pathogenesis remains to be clarified. Here, we describe a case of a 75-year old man with Hodgkin's lymphoma, who had presented with polymyalgic symptoms suggesting polymyalgia rheumatica. An intensive investigation with respect to malignancy was initially negative. Corticosteroid treatment was administered first and a dramatic clinical improvement was achieved. Four months later, when the corticosteroid treatment was tapered off, the initial manifestations reappeared. After the development of lymph node enlargement, the patient was diagnosed by lymph node biopsy as having Hodgkin's lymphoma. The lymphadenopathy and musculoskeletal manifestations all responded well to chemotherapy. Hodgkin's lymphoma should be considered in the differential diagnosis of PMR. These musculoskeletal syndromes should alert the physician to possible paraneoplastic manifestations of an evolving neoplasm.

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Un gros rein et des ganglions

Coutant-Perronne

Lacroix-Szmania

Godeau

et al. 1996

La Revue de Médecine Interne

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Sarcoïdose et réaction sarcoïdosique associées à la maladie de Hodgkin

Cited by 6 publications

References 10 publications

Benign proliferative lesions mimicking recurrence of Hodgkin's disease

Benign proliferative lesions mimicking recurrence of Hodgkin's disease

Hodgkin's lymphoma initially presenting with polymyalgic symptoms: a case report

Un gros rein et des ganglions

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