Sarcoid reactions in malignant tumours

Brincker, H

doi:10.1016/0305-7372(86)90002-2

Cited by 387 publications

(370 citation statements)

References 33 publications

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“…These results are in line with those described by others authors (18)(19)(20) (26). If diagnosis requires pulmonary tissue, multiple lung segments may need to be sampled to achieve at least 85% of diagnostic yield of transbronchial biopsy for sarcoidosis (27) …”

Section: Related To the Different Health Status Of Our Patients As Wesupporting

confidence: 89%

Diagnostic Value of Epithelioid Cell Granulomas in Bronchoscopic Biopsies

Danila

Žurauskas

2008

Intern. Med.

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Section: Related To the Different Health Status Of Our Patients As Wesupporting

confidence: 89%

Diagnostic Value of Epithelioid Cell Granulomas in Bronchoscopic Biopsies

Danila

Žurauskas

2008

Intern. Med.

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“…6,7 SLRs have been described in patients with LPDs, either at the site of malignancy or at sites distinct from the reaction. 8 The reported frequency of non-caseating granulomas in patients with lymphoproliferative disorders is in the range of 7-14%. 8 Typically, these reactions are associated with local non-caseating granulomata and lack of symptoms, but their presence can cause diagnostic confusion or lead to inappropriate disease staging.…”

Section: Discussionmentioning

confidence: 99%

“…8 The reported frequency of non-caseating granulomas in patients with lymphoproliferative disorders is in the range of 7-14%. 8 Typically, these reactions are associated with local non-caseating granulomata and lack of symptoms, but their presence can cause diagnostic confusion or lead to inappropriate disease staging. Although a distinction is often made between an SLR and systemic sarcoidosis, it is possible that these two entities represent the clinical extremes of a common pathological process.…”

Section: Discussionmentioning

confidence: 99%

Dermatomyositis and sarcoid-like reaction associated with multiple myeloma treated effectively by high-dose chemotherapy and autologous peripheral blood stem cell transplantation

Chakraverty

Rabin

Peggs

et al. 2001

Bone Marrow Transplant

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Summary:We report the case of a 46-year-old male who developed dermatomyositis and a sarcoid-like reaction in association with testicular relapse of multiple myeloma. The myositis progressed despite chemotherapy directed at the underlying malignant disorder and immunosuppressive treatment. There was, however, a dramatic and sustained response to high-dose chemotherapy and autologous peripheral blood stem cell transplantation which resulted in resolution of the myopathy and partial resolution of the sarcoid-like reaction. This case report highlights the potential of autologous stem cell transplantation as treatment for para-neoplastic disorders associated with haematological malignancies. Bone Marrow Transplantation (2001) 27, 1215-1217. Keywords: multiple myeloma; autologous PBSCT; dermatomyositis; sarcoidosis The presenting clinical features of multiple myeloma are protean and reflect the direct effects of clonal plasma cell proliferation (eg bone marrow failure), the activity of monoclonal antibody (eg amyloid deposition), or the consequence of a complex inter-relationship between the abnormal clone and the host bone marrow micro-environment (eg bone disease). The pathogenesis of the various 'paraneoplastic' disorders which occur in association with myeloma, such as axonal or demyelinating neuropathy, is less certain although antibodies with specificity for proteins expressed by affected tissues, amyloid deposition or changes in cytokine production patterns have all been proposed as potential mechanisms. The optimal treatment for this group of disorders has not been defined and their impact upon prognosis is not known. We report for the first time the effectiveness of high-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT) as treatment for a para-neoplastic disorder associated with multiple myeloma. Case reportA 46-year-old man presented with a 3 month history of general malaise and 2 week history of vomiting in March 1998. There was no significant past medical history. On examination he appeared unwell and short of breath at rest. He had a raised venous pressure, peripheral oedema and bilateral inspiratory crepitations on chest examination. FBC at presentation was: Hb 8.2 g/dl, white cell count 5.2 × 10 9 /l and platelets 163 ϫ 10 9 /l. Renal function tests confirmed acute renal failure with a creatinine of 844 umol/l (normal range 62-130) and urea 46.4 mmol/l (normal range 2.8-7.6). Corrected serum calcium was 3.43 mmol/l. Chest Xray showed changes consistent with pulmonary oedema. Serum electrophoresis confirmed an IgG lambda paraprotein of 70 g/l. No urinary Bence-Jones protein was detected. Skeletal survey revealed no lytic lesions. Bone marrow trephine was diffusely fibrotic with deposition of collagen (grade 4) and heavy infiltration by neoplastic plasma cells (CD138 positive, lambda light chain restriction). Most plasma cells had the features of plasmblasts. Renal biopsy showed a cast nephropathy.The diagnosis was of IgG lambda myeloma complicated by hypercalcaemia and acute rena...

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“…Sarcoid reactions have been reported to occur in a variety of malignant diseases and have a high incidence in lymphoproliferative disorders such as Hodgkin's disease or non-Hodgkin's lymphoma.The overall incidence of this reaction in patients with carcinoma has been reported to be 4.4% (3). With regard to lung cancer patients, Laurberg et al (4) reported that 20 out of 630 patients (3.2%) had sarcoid reactions in the mediastinal lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that non-caseating epithelioid cell granulomas are occasionally found in lymph nodes draining a region containing the malignant tumor in patients with malignant diseases (1)(2)(3)(4). Such tumor-associated histologic changes have been termed "sarcoid reaction", but this is not indicative of systemic sarcoidosis.…”

Section: Introductionmentioning

confidence: 99%

Sarcoid Reaction in Primary Tumor of Bronchogenic Large Cell Carcinoma Accompanied with Massive Necrosis.

Kashiwabara¹,

Toyonaga²,

Yamaguchi³

et al. 2001

Intern. Med.

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A 49-year-old womanconsulted our hospital for evaluation of a tumor with cavitation in the S6 segment of the right lung. She was given a diagnosis of pulmonary tuberculoma because percutaneous needle aspiration cytology revealed epithelioid cells with a background of necrosis. However, a diagnosis of large cell carcinoma with central necrosis (p-T2N0M0) was established by thoracoscopic lung biopsy six months later. Pathological findings of surgical resection specimens showed that epithelioid cell granulomas adjacent to the neoplasm had a sarcoid reaction and the necrosis was related to the rapidly growing tumor because there was no clinical evidence of systemic sarcoidosis and pulmonary mycobacterial or fungal infection. This is the first report in which sarcoid reactions were recognized in a primary large cell carcinoma.

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Sarcoid reactions in malignant tumours

Cited by 387 publications

References 33 publications

Diagnostic Value of Epithelioid Cell Granulomas in Bronchoscopic Biopsies

Diagnostic Value of Epithelioid Cell Granulomas in Bronchoscopic Biopsies

Dermatomyositis and sarcoid-like reaction associated with multiple myeloma treated effectively by high-dose chemotherapy and autologous peripheral blood stem cell transplantation

Sarcoid Reaction in Primary Tumor of Bronchogenic Large Cell Carcinoma Accompanied with Massive Necrosis.

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