Sarco-Osteoporosis: Prevalence and Association with Frailty in Chinese Community-Dwelling Older Adults

Abstract

The aim was to apply AWGS criteria to estimate the prevalence of sarco-osteoporosis and investigate its relationship with frailty, in a sample of 316 community-dwelling Chinese older people. Regression analysis was performed using frailty as the dependent variable. The results showed that the prevalence rate of sarco-osteoporosis was 10.4% in older men and 15.1% in older women. ≧80 years old (OR 4.8; 95% CI, 3.05–10.76; P = 0.027), women (OR 2.6; 95% CI, 1.18–2.76; P = 0.036), and higher level of comorbidity (OR 3.71; 95% CI, 1.61–10.43; P = 0.021) were independently associated with the likelihood of being sarco-osteoporosis. In the frail group, sarco-osteoporosis occurred in 26.3% of men, in 38.5% of women, and in lower proportion in the prefrail (13.6% of men; 16.2% of women) and nonfrail group (1.6% of men; 1.9% of women) (P < 0.05, resp.). Furthermore, the likelihood of being frail/prefrail was substantially higher in the presence of sarco-osteoporosis (OR 4.16; 95% CI, 2.17–17.65; P = 0.019 in men; and OR 4.67; 95% CI, 2.42–18.86; P = 0.007 in women). The results indicate that patients with sarco-osteoporosis are more likely to be ≧80 yrs with higher burden of comorbidities and to have frailty/prefrailty, especially for women.

Osteosarcopenia: where bone, muscle, and fat collide

“…In a cross-sectional study conducted in Australia in 2015 involving 680 community-dwelling older individuals with a history of falls, almost 40% were osteosarcopenic [6]. Also in 2015, a study of community-dwelling Chinese elders over 65 years, found a prevalence of osteosarcopenia in 10.4% of men and 15.1% of women with higher age (more than 80 years), frailty and a greater level of comorbidity independently associated with the likelihood of being osteosarcopenic [23].…”

“…Indeed, the osteosarcopenic population is at higher risk not only for fractures, but also for depression and impaired mobility [6]. Bone and muscle loss also may be tightly linked to the risk of frailty as shown in a 2015 study conducted in China in which osteosarcopenia was found in 26.3% of men and 38.5% of women with frailty and only in 1.6% and 1.9% of non-frail men and women respectively [23].…”

Osteocalcin Induces Proliferation via Positive Activation of the PI3K/Akt, P38 MAPK Pathways and Promotes Differentiation Through Activation of the GPRC6A-ERK1/2 Pathway in C2C12 Myoblast Cells

“…Bone and muscle are neighbours with close ties. We and others have shown that decreases in muscle and bone mass accompany ageing [5][6][7]. Given the scope of the problem, it is critical to obtain a better understanding of how these two tissues integrate and crosstalk as a basis for identifying new therapeutics that can be used to prevent the loss of muscle and bone with ageing.…”

Function, Role, and Clinical Application of MicroRNAs in Vascular Aging

“…Aging is a multifactorial process characterized by a progressive loss of physiological integrity and functionality, which increases mortality and susceptibility to diseases, including cardiovascular diseases, diabetes, osteoporosis, immunological diseases, various neurodegenerative diseases, and cancer [1–3]. Vascular aging is a specific type of organic aging playing a key role in the process of overall aging.…”