“…Sapropterin (Kuvan, Merck, London, UK), a synthetic analogue of BH4, is a novel agent approved for certain subtypes of phenylketonuria (it is considered an orphan drug) (22)(23)(24)(25). Th ough there is limited experience with its administration, it has shown a very favorable safety profi le in healthy volunteers and patients with phenylketonuria ( 26 ).…”
Sapropterin, an oral synthetic analogue of BH4, at the used dose did not reduce portal pressure in patients with cirrhosis. Sapropterin was safe and no serious adverse effects or deleterious systemic hemodynamic effects were observed.
“…Sapropterin (Kuvan, Merck, London, UK), a synthetic analogue of BH4, is a novel agent approved for certain subtypes of phenylketonuria (it is considered an orphan drug) (22)(23)(24)(25). Th ough there is limited experience with its administration, it has shown a very favorable safety profi le in healthy volunteers and patients with phenylketonuria ( 26 ).…”
Sapropterin, an oral synthetic analogue of BH4, at the used dose did not reduce portal pressure in patients with cirrhosis. Sapropterin was safe and no serious adverse effects or deleterious systemic hemodynamic effects were observed.
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