Saponins Used in Traditional and Modern Medicine

Waller, George R.; Yamasaki, Kazuo

doi:10.1007/978-1-4899-1367-8

Cited by 50 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The broad-spectrum activity of tetraose SGAs is attractive, but this non-specificity also presents a risk. The antifungal and anti-insect activity of SGAs from S. commersonii is not restricted to potato pathogens and pests, but could also affect beneficial or commensal micro-organisms or other animals that feed on plants ( Roddick, 1996 ; Eich, 2008 ). In tomato fruit, α-tomatine is converted to esculeoside A during fruit ripening in a natural detoxification process from the plant ( Nakayasu et al, 2020 ; Szymański et al, 2020 ) to facilitate dispersal of the seeds by foraging animals.…”

Section: Discussionmentioning

confidence: 99%

“…The protective effect of SGAs stems from their ability to interact with membrane sterols, disrupting the cell integrity from target organisms ( Keukens et al, 1995 ; Armah et al, 1999 ; Fenwick et al, 1991 ; Osbourn, 1996 ). In addition, they can act on the nervous system of pests and herbivores through their inhibitory effect on cholinesterase enzymes ( Orgell et al, 1958 ; Wierenga and Hollingworth, 1992 ; Roddick, 1996 ). As a consequence, SGAs can have both antimicrobial and anti-insect activity ( Chowański et al, 2016 ; Munafo and Gianfagna, 2011 ; You and van Kan, 2021 ; Sinden et al, 1986 ; Sinden et al, 1980 ; Tai et al, 2015 ; Tai et al, 2014 ; Paudel et al, 2019 ; Kaup et al, 2005 ; Seipke and Loria, 2008 ; Paudel et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tetraose steroidal glycoalkaloids from potato provide resistance against Alternaria solani and Colorado potato beetle

Wolters

Wouters

Tikunov

et al. 2023

eLife

View full text Add to dashboard Cite

Plants with innate disease and pest resistance can contribute to more sustainable agriculture. Plant breeders typically focus on immune receptors or impaired susceptibility genes to develop resistant crops, but these can present challenges in terms of strength, durability or pleotropic effects. Although natural defence compounds produced by plants have the potential to provide a general protective effect against pathogens and pests, they are not a primary target in resistance breeding. The precise contribution of defence metabolites to plant immunity is often unclear and the genetics underlying their biosynthesis is complex. Here, we identified a wild relative of potato, Solanum commersonii, that provides us with unique insight in the role of glycoalkaloids in plant immunity. We cloned two atypical resistance genes that can provide complete resistance to Alternaria solani and Colorado potato beetle through the production of tetraose steroidal glycoalkaloids. Moreover, we show that these compounds are active against a wide variety of fungi. This research provides a direct link between specific modifications to steroidal glycoalkaloids of potato and resistance against diseases and pests. Further research on the biosynthesis of plant defence compounds in different tissues, their toxicity, and the mechanisms for detoxification, can aid the effective use of such compounds to improve sustainability of our food production.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tetraose steroidal glycoalkaloids from potato provide resistance against Alternaria solani and Colorado potato beetle

Wolters

Wouters

Tikunov

et al. 2023

eLife

View full text Add to dashboard Cite

show abstract

“…(S. anguvi). S. indicum has been reported as a synonym for Solanum anguivi by some authors [111][112][113][114], while others have described them as different species [106,115,116]. Controversy also exists regarding the safety of S. indicum L. fruit (SILF).…”

Section: Solanum Anguivi Lam Fruit's Antidiabetic Properties and Potential Mechanisms Of Actionmentioning

confidence: 99%

Solanum anguivi Lam. Fruits: Their Potential Effects on Type 2 Diabetes Mellitus

et al. 2021

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder of glucose homeostasis associated with a status of insulin resistance, impaired insulin signaling, β-cell dysfunction, impaired glucose and lipid metabolism, sub-clinical inflammation, and increased oxidative stress. Consuming fruits and vegetables rich in phytochemicals with potential antidiabetic effects may prevent T2DM and/or support a conservative T2DM treatment while being safer and more affordable for people from low-income countries. Solanum anguivi Lam. fruits (SALF) have been suggested to exhibit antidiabetic properties, potentially due to the presence of various phytochemicals, including saponins, phenolics, alkaloids, ascorbic acid, and flavonoids. For the saponin fraction, antidiabetic effects have already been reported. However, it remains unclear whether this is also true for the other phytochemicals present in SALF. This review article covers information on glucose homeostasis, T2DM pathogenesis, and also the potential antidiabetic effects of phytochemicals present in SALF, including their potential mechanisms of action.

show abstract

“…It belongs to the family, Portulacaceae. Talinum triangulare plant is found in west Africa, West Indies, South America (Adams, 1999) and in warmer parts of the world (Xu, 1996). Water leaf has catalase, flavonoid, tannins, saponins, alkaloids, and alpha and beta-trocopherds contents.…”

Section: Introductionmentioning

confidence: 99%

Study of Some Phytochemicals in Talinium Triangulare Leaves

2019

CMR

View full text Add to dashboard Cite

The phytochemical analysis of moringa leaves (wet and dry) using standard procedures shows it contains (%) saponin 1.10%, flavonoid 1.10%, alkaloid 2.06% and cyanogenic glycoside 0.0062% while the saponin, flavoniod, alkaloid and cyanogenic glycoside for the wet leaves include 0.80%, 0.80%, 1.02 and 0.005% respectively. This result shows that the presence of saponin, alkaloid and cyanogenic glycoside are higher in the dry leaves comparatively to the wet leaves, while flavonoid is higher in concentration in moringa oleifera flower than its leaves. . It has been shown from the analysis that the percentages of the phytochemicals are not lethal especially the cyanogenic glycoside in the sample which indicates less toxicity and a minor quantity of hydrogen cyanide which can easily be detoxified for better health benefits.

show abstract

Saponins Used in Traditional and Modern Medicine

Cited by 50 publications

References 50 publications

Tetraose steroidal glycoalkaloids from potato provide resistance against Alternaria solani and Colorado potato beetle

Tetraose steroidal glycoalkaloids from potato provide resistance against Alternaria solani and Colorado potato beetle

Solanum anguivi Lam. Fruits: Their Potential Effects on Type 2 Diabetes Mellitus

Study of Some Phytochemicals in Talinium Triangulare Leaves

Contact Info

Product

Resources

About